LOINC
Version 2.67

82992-9SUMO-activating enzyme subunit 1 IgG Ab [Presence] in Serum by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP230275-2   SUMO-activating enzyme subunit 1 Ab.IgG
Small ubiquitin-like modifier 1 (SUMO-1) is one of four enzymes in the SUMO family which plays a key role in posttranslational protein modification. SUMO-1 consists of the SUMO-1 activating enzyme A subunit (SAE1) and the SUMO-1 activating enzyme B subunit (SAE2), which have molecular weights of 40kD and 90kD, respectively. The SUMO family has been associated with diseases such as rheumatoid arthritis and primary biliary cirrhosis. SAE1 and SAE2 have been found in patients with dermatomyositis (DM) associated with widespread skin involvement, dysphagia, and interstitial pneumonia. Patients with DM without these specific associated symptoms are typically anti-SAE antibody negative. [PMID: 17763420] Source: Regenstrief LOINC, PMID: 17763420

Fully-Specified Name

Component
SUMO-activating enzyme subunit 1 Ab.IgG
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Line blot

Additional Names

Short Name
SAE1 IgG Ser Ql Line blot
Display Name
SUMO-activating enzyme subunit 1 IgG Line blot Ql (S)

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
SUMO-活化酶亚基 1 抗体.IgG:存在情况或阈值:时间点:血清:序数型:线点印迹法
nl-NLDutch (NETHERLANDS)
SUMO-activerend enzym subeenheid 1 As.IgG:aanwezigheid:moment:serum:ordinaal:lijnblot
fr-FRFrench (FRANCE)
SAE1 anticorps IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
de-ATGerman (AUSTRIA)
SAE-1 Antikörper qualitativ
es-ESSpanish (SPAIN)
subunidad 1 de la enzima activadora de SUMO IgG:PrThr:Punto temporal:Suero:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82992-9