Version 2.67

82993-7Mj IgG Ab [Presence] in Serum by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP230276-0   Mj Ab.IgG
Anti-Mj autoantibodies have been associated with adult polymyositis (PM) and dermatomyositis (DM), as well as juvenile dermatomyositis (JDM). The target of anti-Mj antibodies has been identified as NXP-2, also known as MORC3, a nuclear protein that has many functions including RNA metabolism and the maintenance of nuclear structure. Anti-Mj positive JDM has been associated with significant muscle weakness, polyarthritis, joint contractures, and intestinal vasculitis. Anti-Mj positive adult-onset DM is associated with calcinosis and a good response to therapy. [PMID: 22546500] Source: Regenstrief LOINC, PMID: 22546500

Fully-Specified Name

Line blot

Additional Names

Short Name
Mj IgG Ser Ql Line blot
Display Name
Mj IgG Line blot Ql (S)

Basic Attributes

First Released
Version 2.58
Last Updated
Version 2.64
Change Reason
Mj changed to MJ to reflect the standard terminology.; This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
Mj 抗体.IgG:存在情况或阈值:时间点:血清:序数型:线点印迹法
Mj As.IgG:aanwezigheid:moment:serum:ordinaal:lijnblot
fr-FRFrench (FRANCE)
MJ anticorps IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
es-ESSpanish (SPAIN)
Mj IgG:PrThr:Punto temporal:Suero:Ord:Line blot

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