Version 2.73

82996-0Mi-2 beta IgG Ab [Presence] in Serum by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP230325-5   Mi-2 beta Ab.IgG
Anti-Mi-2 antibodies are an effective biomarker for idiopathic inflammatory myopathies. Mi-2 antibodies have been identified in patients diagnosed with dermatomyositis, polymyositis and inclusion body myositis.[PMID:16410528] Cutaneous attributes associated with Mi-2 antibody levels include Gottron's papules, heliotrope rash, V-sign and shawl sign rashes and cuticular overgrowth. Patients with Mi-2 antibodies usually have milder muscle issues, a decreased risk of interstitial lung disease (ILD) and decreased risk of malignancy. They also respond better to immunotherapy and can expect a better prognosis. [PMID:26602539] The subfamily of Mi-2 includes Mi-2 alpha and Mi-2 beta. (http://www.snf2.net/snf2/subfamilies/mi2.shtml) Patients with antibodies to different fragments of the Mi-2 beta antigen experience little difference in symptoms and outcome than those with Mi-2 alpha antibodies except for a possible increased risk of cancer.[PMID:16410528] Source: Regenstrief LOINC

Fully-Specified Name

Mi-2 beta Ab.IgG
Line blot

Additional Names

Short Name
Mi-2 beta IgG Ser Ql Line blot
Display Name
Mi-2 beta IgG Line blot Ql (S)
Consumer Name Alpha
Mi-2 beta IgG antibody, Blood

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation

Language Variants Get Info

zh-CNChinese (China)
Mi-2 beta 抗体.IgG:存在情况或阈值:时间点:血清:序数型:线点印迹法
nl-NLDutch (Netherlands)
Mi-2 bèta As.IgG:aanwezigheid:moment:serum:ordinaal:lijnblot
fr-FRFrench (France)
Mi-2 bêta anticorps IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-ITItalian (Italy)
Mi-2 beta Ab.IgG:PrThr:Pt:Siero:Ord:Line blot
es-MXSpanish (Mexico)
Mi-2 beta Ab.IgG:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
es-ESSpanish (Spain)
Anti Mi-2 beta IgG:PrThr:Punto temporal:Suero:Ord:Line blot

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