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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP230331-3   Dense fine speckled 70 protein Ab.IgG
Antinuclear antibodies are essential to diagnose systemic autoimmune rheumatic diseases (SARDs) such as Lupus erythematosus and scleroderma. However, 20-30% of healthy people test positive for ANAs,half of which are dense fine speckled 70 protein (DFS70) antibodies. DFS70 antibodies have been found in patients with various chronic inflammatory diseases but no one disease in particular. It has been suggested that the best use for measuring DFS70 antibodies might be as a biomarker that excludes the diagnosis of SARD since DFS70 antibodies are more often found in patients without active SARD than with it. Antibody titers of DFS70 are highest in healthy young females and the titers decline as a person ages.( http://cli-online.com/featured-articles/anti-dfs70-antibodies-detection-and-significance/) Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Dense fine speckled 70 protein Ab.IgG:PrThr:Pt:Ser/Plas:Ord:Line blot
Long Common Name
Dense fine speckled 70 protein IgG Ab [Presence] in Serum or Plasma by Line blot
Short Name
DFS70 IgG SerPl Ql Line blot
Display Name
Dense fine speckled 70 protein IgG Line blot Ql
Consumer Name Alpha Get Info
Dense fine speckled 70 protein IgG antibody, Blood

Part Model Get Info

  • Component
    Dense fine speckled 70 protein Ab.IgG
    LP230331-3
    • Analyte
      Dense fine speckled 70 protein Ab.IgG
      LP230331-3
      • Component Numerator
        Dense fine speckled 70 protein Ab.IgG
        LP230331-3
        • Component Numerator Core
          Dense fine speckled 70 protein
          LP230329-7
        • Component Numerator Core Suffix
          Ab.IgG
          LP32401-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Line blot
    LP266806-1

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG50952-7Dense fine speckled 70 protein Ab.IgG|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Dense fine speckled 70 protein (DFS70) IgG:Přítomnost nebo práh:Časový bod:Sérum/plazma:Ordinální:Line blot
de-ATGerman (Austria)Synonyms: DFS70-AK ql.
de-DEGerman (Germany)Dichtes fein gesprenkeltes 70-Protein (DFS70) Ak.IgG:Nachweis oder Schwellenwert:Zeitpunkt:Serum oder Plasma:Ordinal:Line-Blot
el-GRGreek (Greece)Πυκνή λεπτόκοκκη πρωτεΐνη 70 Αντισώματα IgG:PrThr:Pt:Ορός/Πλάσμα:Ord:Γραμμή κηλίδωσης
Synonyms: Ord PrThr Pt SERO Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Γραμμή κηλίδωσης Ορός Ορός/Πλάσμα Πλάσμα Πρωτεΐνη Πυκνή λεπτόκοκκη πρωτεΐνη 70
es-ESSpanish (Spain)Proteína densa fina moteada 70 IgG:PrThr:Punto temporal:Suero o Plasma:Ord:Line blot
es-MXSpanish (Mexico)Ab.IgG de proteína 70 moteada fina y densa:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Mancha de línea
fr-FRFrench (France)DFS70 Ac IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Blot en ligne
it-ITItalian (Italy)Proteina 70 densa fine punteggiata Ab.IgG:PrThr:Pt:Siero/Plasma:Ord:Line blot
Synonyms: anticorpi IgG anticorpo Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)dense fine speckled 70 protein As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:lijnblot
Synonyms: antistof; antilichaam DFS70
pl-PLPolish (Poland)Gęste drobnoziarniste białko 70 Ab.IgG:granica wykrywalności:punkt w czasie:surowica lub osocze:uporządkowany:line blot
Synonyms: Białko DFS70 IgG Przeciwciała do antygenu Dense fine speckled 70(DFS70) przeciwciała IgG Przeciwciała IgG do antygenu Dense fine speckled 70(DFS70)
zh-CNChinese (China)致密细斑 70 蛋白 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:线点印迹法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 DFS70;DFS-70;DFS 70-kDa;致密精细斑点 70 蛋白 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫球蛋白 G 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 血清或血浆

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82998-6