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Term Description

This term should be used to report the narrative impression of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone 22C3. Patients with certain cancers, such as non-small cell lung cancer (NSCLC), whose tumors are positive for PD-L1 by 22C3 may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using LOINC 83053-9, and the ordinal result for PD-L1 expression using LOINC 83052-1. This term was created for, but is not limited in use to, the Dako PD-L1 22C3 pharmDx test kit, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with specific cancers are eligible for pembrolizumab therapy.

LOINC Names Get Info

Fully-Specified Name
Programmed cell death ligand 1 by clone 22C3:Imp:Pt:Tiss:Nar:Immune stain
Long Common Name
PD-L1 by clone 22C3 [Interpretation] in Tissue by Immune stain Narrative
Short Name
PD-L1 by 22C3 Tiss ImStn-Imp
Display Name
PD-L1 by clone 22C3 Immune stain Nar (Tiss) [Interp]
Consumer Name Alpha Get Info
Interpretation of PD-L1 by clone 22C3 test result, Tissue

Part Model Get Info

  • Component
    Programmed cell death ligand 1 by clone 22C3
    LP232100-0
    • Analyte
      Programmed cell death ligand 1 by clone 22C3
      LP232100-0
      • Component Numerator
        Programmed cell death ligand 1 by clone 22C3
        LP232100-0
        • Component Numerator Core
          Programmed cell death ligand 1 by clone 22C3
          LP232100-0
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Imp
    LP6819-9
  • Time
    Pt
    LP6960-1
  • System
    Tiss
    LP7641-6
    • System Core
      Tiss
      LP7641-6
    • Super System
      NULL
       
  • Scale
    Nar
    LP7749-7
  • Method
    Immune stain
    LP6333-1

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Observation
Common Test Rank Get Info
19499

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)PD-L1 pomocí klonu 22C3:Interpretace:Časový bod:Tkáně a stěry:Narativní:Imunobarvení
el-GRGreek (Greece)Συνδέτης προγραμματισμένου κυτταρικού θανάτου 1 από τον κλώνο 22C3:Imp:Pt:Ιστός:Nar:Ανοσολογική χρώση
Synonyms: Imp Nar PATH Pt Ανοσολογική χρώση Ιστός Συνδέτης προγραμματισμένου κυτταρικού θανάτου 1 από τον κλώνο 22C3
es-ESSpanish (Spain)Ligando 1 de la molécula de muerte programada por el clon 22C3 (PD-L1 clon 22C3):Impresión/interpretación del estudio:Punto temporal:Tejido:Narrativo:Tinción de inmunohistoquímica
es-MXSpanish (Mexico)Ligando 1 de muerte celular programada por el clon 22C3:Impresión / interpretación del estudio:Punto temporal:Tejido y frotis:Narrativo:Mancha inmune
it-ITItalian (Italy)Morte cellulare programmata ligando 1 tramite clone 22C3:Imp:Pt:Tessuto:Nar:Colorazione immunologica
Synonyms: Impressione/interpretazione di studio Patologia PD-L1 tramite clone 22C3 Punto nel tempo (episodio) Tessuto & Strisci
pl-PLPolish (Poland)Ligand dla receptora programowanej śmierci 1 przez klon 22C3:ocena:punkt w czasie:tkanka i rozmazy:opisowy:barwienie immunohistochemiczne
Synonyms: Ligand dla receptora programowanej śmierci wykryty przez przeciwciało monoklonalne (klon 22C3); detekcja PD-L1 przez przeciwciało monoklonalne klon 22C3 Ligand receptora programowanej śmierci 1
zh-CNChinese (China)采用克隆 22C3 所测定的程序性死亡配体 1:印象:时间点:组织与涂片:叙述型:免疫染色法
Synonyms: Ⅰ I 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法 采用克隆（PD-L1抗体克隆） 22C3 所测定的 PD-L1

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83054-7