LOINC
Version 2.66

83054-7PD-L1 by clone 22C3 [Interpretation] in Tissue by Immune stain NarrativeActive

Component
Programmed cell death ligand 1 by clone 22C3
Property
Imp
Time
Pt
System
Tiss
Scale
Nar
Method
Immune stain

Additional Names

Short Name
PD-L1 by 22C3 Tiss ImStn-Imp
Display Name Beta
PD-L1 by clone 22C3 Immune stain Nar (Tiss) [Interp]
Consumer Name Alpha
Interpretation of PD-L1 by Clone 22C3 Test Result, Tissue

Term Description

This term should be used to report the narrative impression of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone 22C3. Patients with certain cancers, such as non-small cell lung cancer (NSCLC), whose tumors are positive for PD-L1 by 22C3 may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using [LOINC:83053-9], and the ordinal result for PD-L1 expression using [LOINC: 83052-1]. This term was created for, but is not limited in use to, the Dako PD-L1 22C3 pharmDx test kit, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with specific cancers are eligible for pembrolizumab therapy.
Source: Regenstrief LOINC

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation
Observation

Language Variants Get Info

zh-CNChinese (China)
采用克隆 22C3 所测定的程序性死亡配体 1:印象:时间点:组织与涂片:叙述型:免疫染色法
it-ITItalian (Italy)
Proteina della morte programmata ligando 1 tramite clone 22C3:Imp:Pt:Tessuto:Nar:Colorazione immunologica
es-ESSpanish (Spain)
Ligando 1 de la molécula de muerte programada por el clon 22C3 (PD-L1 clon 22C3):Impresión/interpretación del estudio:Punto temporal:Tejido:Narrativo:Tinción de inmunohistoquímica

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83054-7