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Term Description

This term should be used to report the narrative impression of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone 28-8. Patients with certain cancers, such as non-squamous non small cell lung cancer (NSCLC) or melanoma, whose tumors are positive for PD-L1 by 28-8 may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using LOINC 83053-9, and the ordinal staining result using LOINC 83055-4. This term was created for, but is not limited in use to, the Dako PD-L1 28-8 pharmDx test kit, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with certain cancers are eligible for nivolumab therapy.

LOINC Names Get Info

Fully-Specified Name
Programmed cell death ligand 1 by clone 28-8:Imp:Pt:Tiss:Nar:Immune stain
Long Common Name
PD-L1 by clone 28-8 [Interpretation] in Tissue by Immune stain Narrative
Short Name
PD-L1 by 28-8 Tiss ImStn-Imp
Display Name
PD-L1 by clone 28-8 Immune stain Nar (Tiss) [Interp]
Consumer Name Alpha Get Info
Interpretation of PD-L1 by clone 28-8 test result, Tissue

Part Model Get Info

  • Component
    Programmed cell death ligand 1 by clone 28-8
    LP232099-4
    • Analyte
      Programmed cell death ligand 1 by clone 28-8
      LP232099-4
      • Component Numerator
        Programmed cell death ligand 1 by clone 28-8
        LP232099-4
        • Component Numerator Core
          Programmed cell death ligand 1 by clone 28-8
          LP232099-4
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Imp
    LP6819-9
  • Time
    Pt
    LP6960-1
  • System
    Tiss
    LP7641-6
    • System Core
      Tiss
      LP7641-6
    • Super System
      NULL
       
  • Scale
    Nar
    LP7749-7
  • Method
    Immune stain
    LP6333-1

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58 (ADD)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)PD-L1 pomocí klonu 28-8:Interpretace:Časový bod:Tkáně a stěry:Narativní:Imunobarvení
el-GRGreek (Greece)Συνδέτης προγραμματισμένου κυτταρικού θανάτου 1 από τον κλώνο 28-8:Imp:Pt:Ιστός:Nar:Ανοσολογική χρώση
Synonyms: Imp Nar PATH Pt Ανοσολογική χρώση Ιστός Συνδέτης προγραμματισμένου κυτταρικού θανάτου 1 από τον κλώνο 28-8
es-ESSpanish (Spain)Ligando 1 de la molécula de muerte programada por el clon 28-8 (PD-L1 clon 28-8):Impresión/interpretación del estudio:Punto temporal:Tejido:Narrativo:Tinción de inmunohistoquímica
es-MXSpanish (Mexico)Ligando 1 de muerte celular programada por el clon 28-8:Impresión / interpretación del estudio:Punto temporal:Tejido y frotis:Narrativo:Mancha inmune
it-ITItalian (Italy)Morte cellulare programmata ligando 1 tramite clone 28-8:Imp:Pt:Tessuto:Nar:Colorazione immunologica
Synonyms: Impressione/interpretazione di studio Patologia PD-L1 tramite clone 28-8 Punto nel tempo (episodio) Tessuto & Strisci
pl-PLPolish (Poland)Ligand dla receptora programowanej śmierci 1 przez klon 28-8:ocena:punkt w czasie:tkanka i rozmazy:opisowy:barwienie immunohistochemiczne
Synonyms: Ligand dla receptora programowanej śmierci (PDL1) wykryty przez przeciwciało monoklonalne (klon 28-8); detekcja PD-L1 przez przeciwciało monoklonalne klon 28-8 Ligand receptora programowanej śmierci 1
zh-CNChinese (China)采用克隆 28-8 所测定的程序性死亡配体 1:印象:时间点:组织与涂片:叙述型:免疫染色法
Synonyms: Ⅰ I 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法 采用克隆（PD-L1抗体克隆） 28-8 所测定的 PD-L1

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83056-2