LOINC
Version 2.66

83056-2PD-L1 by clone 28-8 [Interpretation] in Tissue by Immune stain NarrativeActive

Component
Programmed cell death ligand 1 by clone 28-8
Property
Imp
Time
Pt
System
Tiss
Scale
Nar
Method
Immune stain

Additional Names

Short Name
PD-L1 by 28-8 Tiss ImStn-Imp
Display Name Beta
PD-L1 by clone 28-8 Immune stain Nar (Tiss) [Interp]
Consumer Name Alpha
Interpretation of PD-L1 by Clone 28-8 Test Result, Tissue

Term Description

This term should be used to report the narrative impression of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone 28-8. Patients with certain cancers, such as non-squamous non small cell lung cancer (NSCLC) or melanoma, whose tumors are positive for PD-L1 by 28-8 may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using [LOINC: 83053-9], and the ordinal staining result using [LOINC: 83055-4]. This term was created for, but is not limited in use to, the Dako PD-L1 28-8 pharmDx test kit, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with certain cancers are eligible for nivolumab therapy.
Source: Regenstrief LOINC

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
采用克隆 28-8 所测定的程序性死亡配体 1:印象:时间点:组织与涂片:叙述型:免疫染色法
it-ITItalian (Italy)
Proteina della morte programmata ligando 1 tramite clone 28-8:Imp:Pt:Tessuto:Nar:Colorazione immunologica
es-ESSpanish (Spain)
Ligando 1 de la molécula de muerte programada por el clon 28-8 (PD-L1 clon 28-8):Impresión/interpretación del estudio:Punto temporal:Tejido:Narrativo:Tinción de inmunohistoquímica

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83056-2