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Term Description

This term should be used to report the degree of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone SP142. Patients with certain cancers, such as non small cell lung cancer (NSCLC) or urothelial carcinoma, whose tumors are positive for PD-L1 by SP142, may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using LOINC 83053-9. If at least 50% of tumor cells or at least 10% of inflammatory cells stain positive with SP142, the tumor is considered to have high PD-L1 expression, and if 1 to 50% of tumor cells and 1 to 10% of inflammatory cells stain positive, the tumor has low expression. If <1% of both tumor and inflammatory cells stain positive, the tumor is considered to have no PD-L1 expression. This term was created for, but is not limited in use to, the Ventana PD-L1 (SP142) assay, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with certain cancers are eligible for atezolizumab therapy.

LOINC Names Get Info

Fully-Specified Name
Programmed cell death ligand 1 by clone SP142:PrThr:Pt:Tiss:Ord:Immune stain
Long Common Name
PD-L1 by clone SP142 [Presence] in Tissue by Immune stain
Short Name
PD-L1 by SP142 Tiss Ql ImStn
Display Name
PD-L1 by clone SP142 Immune stain Ql (Tiss)
Consumer Name Alpha Get Info
PD-L1 by Clone SP142, Tissue

Part Model Get Info

  • Component
    Programmed cell death ligand 1 by clone SP142
    LP232484-8
    • Analyte
      Programmed cell death ligand 1 by clone SP142
      LP232484-8
      • Component Numerator
        Programmed cell death ligand 1 by clone SP142
        LP232484-8
        • Component Numerator Core
          Programmed cell death ligand 1 by clone SP142
          LP232484-8
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Tiss
    LP7641-6
    • System Core
      Tiss
      LP7641-6
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Immune stain
    LP6333-1

Example Answer List: LL4167-4

Source: Laboratory Corporation of America
AnswerCodeScoreAnswer ID
No expressionLA26821-1
Low expressionLA26820-3
High expressionLA26819-5

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
17666

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)PD-L1 pomocí klonu SP142:Přítomnost nebo práh:Časový bod:Tkáně a stěry:Ordinální:Imunobarvení
el-GRGreek (Greece)Συνδέτης προγραμματισμένου κυτταρικού θανάτου 1 από τον κλώνο SP142:PrThr:Pt:Ιστός:Ord:Ανοσολογική χρώση
Synonyms: Ord PATH PrThr Pt Ανοσολογική χρώση Ιστός Συνδέτης προγραμματισμένου κυτταρικού θανάτου 1 από τον κλώνο SP142
es-ESSpanish (Spain)Ligando 1 de la molécula de muerte programada por el clon SP142 (PD-L1 clon SP142):PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MXSpanish (Mexico)Ligando 1 de muerte celular programada por el clon SP142:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
it-ITItalian (Italy)Morte cellulare programmata ligando 1 tramite clone SP142:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
Synonyms: Patologia PD-L1 tramite clone SP142 Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
pl-PLPolish (Poland)Ligand dla receptora programowanej śmierci 1 przez klon SP142:granica wykrywalności:punkt w czasie:tkanka i rozmazy:uporządkowany:barwienie immunohistochemiczne
Synonyms: Ligand dla receptora programowanej śmierci (PD-1) wykryty przez przeciwciało monoklonalne SP142; detekcja PD-L1 przez przeciwciało monoklonalne klon SP142 Ligand receptora programowanej śmierci 1
zh-CNChinese (China)采用克隆 SP142 所测定的程序性死亡配体 1:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
Synonyms: Ⅰ I 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法 采用克隆（PD-L1抗体克隆） SP142 所测定的 PD-L1

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83057-0