LOINC
Version 2.66

83057-0PD-L1 by clone SP142 [Presence] in Tissue by Immune stainActive

Component
Programmed cell death ligand 1 by clone SP142
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Short Name
PD-L1 by SP142 Tiss Ql ImStn
Display Name Beta
PD-L1 by clone SP142 Immune stain Ql (Tiss)
Consumer Name Alpha
PD-L1 by Clone SP142, Tissue

Term Description

This term should be used to report the degree of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone SP142. Patients with certain cancers, such as non small cell lung cancer (NSCLC) or urothelial carcinoma, whose tumors are positive for PD-L1 by SP142, may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using [LOINC: 83053-9]. If at least 50% of tumor cells or at least 10% of inflammatory cells stain positive with SP142, the tumor is considered to have high PD-L1 expression, and if 1 to 50% of tumor cells and 1 to 10% of inflammatory cells stain positive, the tumor has low expression. If <1% of both tumor and inflammatory cells stain positive, the tumor is considered to have no PD-L1 expression. This term was created for, but is not limited in use to, the Ventana PD-L1 (SP142) assay, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with certain cancers are eligible for atezolizumab therapy.
Source: Regenstrief LOINC

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation
Both

Example Answer List LL4167-4

Source: Laboratory Corporation of America

Answer Code Score Answer ID
No expression LA26821-1
Low expression LA26820-3
High expression LA26819-5

Language Variants Get Info

zh-CNChinese (China)
采用克隆 SP142 所测定的程序性死亡配体 1:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
it-ITItalian (Italy)
Proteina della morte programmata ligando 1 tramite clone SP142:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
es-ESSpanish (Spain)
Ligando 1 de la molécula de muerte programada por el clon SP142 (PD-L1 clon SP142):PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83057-0