Version 2.78

Term Description

The Influenza A virus genome is contained on eight RNA segments.
Segments 1-3 encode RNA polymerase subunits (segment 1 - PB2, segment 2 - PB1 and the PB1-F2 protein and segment 3 - PA).
Segment 4 encodes for hemagglutinin (HA). HA is a determinant in the severity of a viral infection.
Segment 5 encodes a nucleoprotein (NP)
Segment 6 encodes neuraminidase (NA)
Segment 7 encodes two matrix proteins (M1 and M2)
Segment 8 encodes two distinct non-structural proteins (NS1 and NEP)
Segments that encode multiple proteins due so by using different reading frames from the same RNA segment.
PMID: 19230160The result of this test is the raw amino acid sequence of the virus.
Source: Regenstrief LOINC

Part Descriptions

LP150045-5   Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977. PMID: 271968 Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost. PMID: 18576944 Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template. PMID: 20858600 Source: Regenstrief LOINC

LP248016-0   Influenza virus A whole genome
The influenza A and B virus genomes comprise eight segmented viral RNAs (vRNAs). Each RNA segment encodes 1 or 2 nonstructural proteins. Segmentation of the vRNAs allows viruses to exchange vRNAs with other strains. Although research has shown consistency of the packaging mechanism between viruses, it is more variable than previously thought which is relevant in understanding how infectious and noninfectious virions coordinate to produce infection. PMID: 27601575 Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus A whole genome
Property
Seq
Time
Pt
System
Isolate
Scale
Nom
Method
Sequencing

Additional Names

Long Common Name
Influenza virus A whole genome [Nucleotide sequence] in Isolate by Sequencing
Short Name
FLUAV whole genome Islt-Seq
Display Name
FLUAV whole genome sequence Nom (Isol)
Consumer Name Alpha Get Info
Influenza A Whole Genome

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.61
Order vs. Observation
Observation

Member of these Groups Get Info

LOINC Group Group Name
LG32757-3 Influenza virus

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Influenza-Virus A Gesamtgenom:Sequenz:Zeitpunkt:Isolat:Nominal:Sequenzierung
es-ES Spanish (Spain) genoma completo virus Influenza A:Secuencia de nucleótidos:Punto temporal:Aislado:Nom:Secuenciación
es-MX Spanish (Mexico) Virus de la influenza Un genoma completo:Secuencia de nucleótidos:Punto temporal:Aislado:Nominal:Secuenciación
fr-FR French (France) Influenza virus A génome complet:Séquence nucléotidique:Ponctuel:Isolat:Résultat nominal:Séquençage
it-IT Italian (Italy) Influenza virus A, intero genoma:Seq:Pt:Isolato:Nom:Sequenziamento
Synonyms: Intero genoma del virus dell''influenza A Microbiologia Punto nel tempo (episodio) Sequenza nucleotidica Virus dell''influenza Virus dell''influenza A
nl-NL Dutch (Netherlands) Influenzavirus A volledig genoom:nucleotidevolgorde:moment:isolaat:nominaal:sequencing
pl-PL Polish (Poland) Influenza wirus A cały genom:sekwencja nukleotydu:punkt w czasie:izolat:cecha:sekwencjonowanie
Synonyms: Cały genom wirusa grypy typu A Wirus grypy Wirus grypy typ A
zh-CN Chinese (China) 流感病毒 A 型全基因组:序列:时间点:分离株:名义型:序列测定
Synonyms: A 型 A 型流感;A 型流感病毒;FLUA;FLUAV;家禽鼠疫;流感 A;流感 A 型;流感甲型;流感病毒甲型;甲型流感;甲型流感病毒;瘟疫;禽流感;禽流行性感冒;禽疫;鸡瘟 FLUV;Influ;列性感冒病毒;流行性感冒病毒 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 序列分析;测序 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 时刻;随机;随意;瞬间 核苷酸序列 流感病毒 A 型全（完整、全部）基因组

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85532-0