85622-9

Zika virus RNA [Presence] in Serum or Plasma by NAA with probe detection

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Term Description

This term is used to report the presence of Zika virus RNA in serum. For assays that target the Zika virus envelope (E) gene, use [LOINC: 81149-7]. This term was created for , but is not limited in use to, the Altona RealStar Zika virus PCR assay.
Source: Regenstrief LOINC

Part Descriptions

LP200137-0 Zika virus
Zika virus (ZIKV) is a flavivirus transmitted primarily by the Aedes mosquito which was first identified in a sentinel monkey in the Zika forest in Uganda in 1947. Since 2014 it has spread explosively in the Americas where it has infected hundreds of thousands of people. About 80% of those infected are asymptomatic. Common symptoms include fever, headache, rash, arthralgia and conjunctivitis. Since the end of 2015, there has been an increase in ZIKV-associated cases of Guillain-Barre syndrome and a tremendous increase in cases of microcephaly in fetuses and newborns in Brazil, raising worldwide public health concern. Recent predictions are that the mosquito species A. Albopictus, which can hibernate and survive cool temperatures, will carry ZIKV to more temperate areas of North America, Australia and Southern Europe. It is still not clear whether ZIKV in humans increases viral titers enough to trigger a new cycle when an infected person is bitten by a naïve mosquito. Direct human-to-human transmission has been documented to occur perinatally, sexually (primarily through semen), through breastfeeding, blood transfusion and through occupational transmission in the laboratory setting. There are currently no specific anti-viral agents, vaccination or medical prophylaxis available. PMID: 27148186 Source: Regenstrief LOINC

LP203271-4 Zika virus RNA
Zika virus contains an inner nucleocapsid composed of RNA and multiple copies of the viral capsid (C) protein. The outer host contains 180 copies each of two proteins: the viral membrane (M) protein and the envelope (E) protein (Kostyuchenko et al., 2016; Sirohi et al., 2016). Viral RNA of the Zika virus has been identified in the brain and liver of fetuses and in the brain, eyes, spleen, liver and placenta of pregnant mothers, with the highest viral load existing in the placenta.(Adams Waldorf et al., 2016). Source: Regenstrief LOINC

Fully-Specified Name

Component: Zika virus RNA
Property: PrThr
Time: Pt
System: Ser/Plas
Scale: Ord
Method: Probe.amp.tar

Additional Names

Short Name: ZIKV RNA SerPl Ql NAA+probe
Display Name: ZIKV RNA NAA+probe Ql
Consumer Name Alpha Get Info: Zika virus, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.61
Last Updated: Version 2.73
Change Reason: Release 2.68: SYSTEM: This test can be performed on serum or plasma specimens.
Order vs. Observation: Both
Common Test Rank Get Info: 8318

Member of these Groups Get Info

LOINC Group	Group Name
LG32774-8	Zika virus

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Zika-Virus RNA:Nachweis oder Schwellenwert:Zeitpunkt:Serum oder Plasma:Ordinal:Zielfragmentamplifikation mit Sondendetektion
es-ES	Spanish (Spain)	Virus Zika RNA:PrThr:Punto temporal:Suero o Plasma:Ord:Sonda con amplificación dirigida
es-MX	Spanish (Mexico)	ARN del virus del Zika:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR	French (France)	Zika virus ARN:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:PCR amplification de cible
it-IT	Italian (Italy)	Zika virus RNA:PrThr:Pt:Siero/Plasma:Ord:Sonda.amp.tar Synonyms: Microbiologia Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Virus Zika
nl-NL	Dutch (Netherlands)	zikavirus RNA:aanwezigheid:moment:serum of plasma:ordinaal:probe-detectie Synonyms: probe.amp.tar Zika-virus
tr-TR	Turkish (Turkey)	Zika virüs RNA:MevcEşik:Zmlı:Ser/Plaz:Srl:Prob.amf.hdf Synonyms: Mevcut
uk-UA	Ukrainian (Ukraine)	РНК вірусу Зіка:Наявність або Поріг:МоментЧасу:Сироватка/Плазма:Порядково:Зонд-детекція. цільова аміпліфікація НК Synonyms: 3 Self-Sustaining Sequence Replication; 3SR SR; Amplif; Amplification; Amplified; DNA NUCLEIC ACID PROBE; DNA probe; ID; Infectious Disease; InfectiousDisease; LAT; LCR; Ligase chain reaction; Ligation-activated transcription; Microbiology; NAA+probe; NAAT; NASBA; Nucleic acid sequence based analysis; Ordinal; PCR; Pl; Plasma; Plsm; Point in time; Polymerase chain reaction; PR; Probe amp; Probe with ampification; Probe with target amplification; QBR; QL; Qual; Qualitative; Random; Ribonucleic acid; Screen; SDA; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR; Strand Displacement Amplification; TMA; Transcription mediated amplification; ZIKV; ZIKV RNA
zh-CN	Chinese (China)	寨卡病毒 RNA:存在情况或阈值:时间点:血清/血浆:序数型:探针法.基因扩增.靶向 Synonyms: 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向塞卡病毒;Zika virus;Zika 病毒;ZIKV;济卡病毒;兹卡病毒存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间核糖核酸;Ribonucleic acid 经过扩增的脱氧核糖核酸探针血清或血浆

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