85832-4

Beta-lactam resistance ESBL blaCTX-M-1 Group gene [Presence] by Molecular method

Active

Term Description

This test reports the presence of the CTX-M1 group extended spectrum beta lactamase gene in gram negative bacterial isolates. This term was created for, but is not limited in use to, the submitter's modified protocol for the Check-Points Check-MDR CT103XL assay.

Part Description

LP248278-6   Bacterial beta-lactam resistance ESBL blaCTX-M-1 Group gene
Extended-spectrum beta-lactamases (ESBL) are enzymes produced by some bacteria that are resistant to the majority of beta-lactam antibiotics which include the penicillins, cephalosporins and the monobactam aztreonam. https://www.uptodate.com/contents/extended-spectrum-beta-lactamases Organisms producing CTX-M type ESBL enzymes have been isolated worldwide with more than 150 enzymes identified. These enzymes have been classified into seven major phylogenetic groups: CTX-M -1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25, CTX-M-74 and CTX-M-75. The rare ESBL type CTX-M-8 has been isolated in Germany, mainly in E. coli, but also in Salmonella and E. aerogenes. CTX-M type ESBL have been isolated worldwide and their incidence has increased dramatically and is still increasing leading to a major therapeutic issue. Currently more than 150 allelic variants of CTX-M have been identified. These enzymes are classified in five major phylogenetic groups based on their gene sequences: CTX-M -1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25; two additional groups have been reported recently: CTX-M-74 and CTX-M-75. The dissemination of these enzymes has caused an increased use of carbapenems for treatment of infections which carries its own risk of furthering resistance. PMID: 25234380 The genes are named with the prefix "bla", which stands for "beta-lactam", followed by the enzyme, for example, blaCTX-M-1. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name

Bacterial beta-lactam resistance ESBL blaCTX-M-1 group gene:PrThr:Pt:Isolate/Specimen:Ord:Molgen

Long Common Name

Beta-lactam resistance ESBL blaCTX-M-1 Group gene [Presence] by Molecular method

Short Name

ESBL blaCTX-M-1 Grp gene Islt/Spm Ql

Display Name

Beta-lactam resistance ESBL blaCTX-M-1 Group gene Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Beta-lactam Resistance ESBL blaCTX-M-1 Group gene

Part Model Get Info

• Component

  Bacterial beta-lactam resistance ESBL blaCTX-M-1 Group gene
  LP248278-6

  • Analyte

    Bacterial beta-lactam resistance ESBL blaCTX-M-1 Group gene
    LP248278-6

    • Component Numerator

      Bacterial beta-lactam resistance ESBL blaCTX-M-1 Group gene
      LP248278-6

      • Component Numerator Core

        Bacterial beta-lactam resistance ESBL blaCTX-M-1 Group gene
        LP248278-6

      • Component Numerator Core Suffix

        NULL
         

    • Component Denominator

      NULL
       

      • Component Denominator Core

        NULL
         

      • Component Denominator Core Suffix

        NULL
         

  • Challenge

    NULL
     

  • Adjustment

    NULL
     

  • Count

    NULL
     

• Property

  PrThr
  LP217195-9

• Time

  Pt
  LP6960-1

  • Time Core

    Pt
    LP6960-1

  • Time Modifier

    NULL
     

• System

  Isolate/Specimen
  LP266970-5

  • System Core

    Isolate/Specimen
    LP266970-5

  • Super System

    NULL
     

• Scale

  Ord
  LP7751-3

• Method

  Molgen
  LP6404-0

Example Answer List: LL360-9

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.67 (MIN)

Change Reason

Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Observation

Member of these Panels

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• B
• Bact
• ESBL blaCTX-M-1 Grp gene
• i
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.

CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85832-4

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to https://www.snomed.org/get-snomed or [email protected]<mailto:[email protected]>. This may incur a fee in SNOMED International non-Member countries.

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.