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Term Description

This term is used for assays that can detect, but not differentiate between the CTX-M-8 and CTX-M-25 extended spectrum beta lactamase genes in gram negative bacterial isolates. If either or both genes are positive, a single result of "positive" is reported. This term was created for, but is not limited in use to, the submitter's modified protocol for the Check-Points Check-MDR CT103XL assay.

Part Description

LP248281-0   Bacterial beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes
Extended-spectrum beta-lactamases (ESBL) are enzymes produced by some bacteria that are resistant to the majority of beta-lactam antibiotics which include the penicillins, cephalosporins and the monobactam aztreonam. https://www.uptodate.com/contents/extended-spectrum-beta-lactamases Organisms producing CTX-M type ESBL enzymes have been isolated worldwide with more than 150 enzymes identified. These enzymes have been classified into seven major phylogenetic groups: CTX-M -1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25, CTX-M-74 and CTX-M-75. The rare ESBL type CTX-M-8 has been isolated in Germany, mainly in E. coli, but also in Salmonella and E. aerogenes. CTX-M type ESBL have been isolated worldwide and their incidence has increased dramatically and is still increasing leading to a major therapeutic issue. Currently more than 150 allelic variants of CTX-M have been identified. These enzymes are classified in five major phylogenetic groups based on their gene sequences: CTX-M -1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25; two additional groups have been reported recently: CTX-M-74 and CTX-M-75. The dissemination of these enzymes has caused an increased use of carbapenems for treatment of infections which carries its own risk of furthering resistance. PMID: 25234380 The genes are named with the prefix "bla", which stands for "beta-lactam", followed by the enzyme, for example, blaCTX-M-1. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Bacterial beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 group genes:PrThr:Pt:Isolate/Specimen:Ord:Molgen
Long Common Name
Beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes [Presence] by Molecular method
Short Name
blaCTX-M-8+blaCTX-M-25 Gr Islt/Spm Ql
Display Name
Beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Beta-lactam Resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes

Part Model Get Info

  • Component
    Bacterial beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes
    LP248281-0
    • Analyte
      Bacterial beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes
      LP248281-0
      • Component Numerator
        Bacterial beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes
        LP248281-0
        • Component Numerator Core
          Bacterial beta-lactam resistance ESBL blaCTX-M-8+blaCTX-M-25 Group genes
          LP248281-0
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Isolate/Specimen
    LP266970-5
    • System Core
      Isolate/Specimen
      LP266970-5
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Molgen
    LP6404-0

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.67 (MIN)
Change Reason
Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Observation

Member of these Panels

LOINCLong Common Name
93698-9Gram negative bacterial resistance panel by Molecular genetics method

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Geny skupiny blaCTX-M-8+blaCTX-M-25 bakteriální rezistence na beta-laktamy ESBL:Přítomnost nebo práh:Časový bod:Izolát/vzorek:Ordinální:Molekulární genetika
de-DEGerman (Germany)Bakterielle Beta-Lactam-Resistenz ESBL blaCTX-M-8+blaCTX-M-25-Gruppen-Gene:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
Synonyms: Extended Spectrum beta-lactamases
el-GRGreek (Greece)Βακτηριακή ανθεκτικότητα στη β-λακτάμη γονίδια ESBL της ομάδας blaCTX-M-8 + blaCTX-M-25:PrThr:Pt:Απομονωθέν στέλεχος/Δείγμα:Ord:Μοριακή γενετική
Synonyms: ABXBACT M Ord PrThr Pt Απομονωθέν στέλεχος/Δείγμα Απομονωμένο στέλεχος Βακτηριακή ανθεκτικότητα στη β-λακτάμη γονίδια ESBL της ομάδας blaCTX-M-8 + blaCTX-M-25 Δείγμα Μοριακή γενετική
es-ESSpanish (Spain)Grupo genes bacterianos ESBL blaCTX-M-8+blaCTX-M-25 resistente a beta-lactámicos:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MXSpanish (Mexico)Resistencia bacteriana a betalactámicos BLEE blaCTX-M-8 + blaCTX-M-25 Genes del grupo:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-FRFrench (France)Résistance bactérienne aux bêta-lactamines groupe de gènes ESBL blaCTX-M-8+blaCTX-M-25:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-ITItalian (Italy)Resistenza batterica beta-lactamica, geni Gruppo ESBL blaCTX-M-8+blaCTX-M-25:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Genetica molecolare Geni Gruppo ESBL blaCTX-M-8+blaCTX-M-25 di resiste Isolato o Campione Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NLDutch (Netherlands)bacteriële bètalactamresistentie ESBL blaCTX-M-8 + blaCTX-M-25 groep genen:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
pl-PLPolish (Poland)Bakteryjna oporność na beta-laktamy ESBL blaCTX-M-8+blaCTX-M-25 Grupa geny:granica wykrywalności:punkt w czasie:szczep/izolat lub próbka:uporządkowany:genetyka molekularna
Synonyms: diagnostyka molekularna Geny bakteryjnej oporności na beta-laktamy ESBL grup blaCTX-M-8 i blaCTX-M-25
zh-CNChinese (China)细菌 beta-内酰胺耐药 ESBL blaCTX-M-8+blaCTX-M-25 组基因:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: B M 型 β 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子病理学 - 基因类 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 受检物 基因 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 细菌 beta-内酰胺（β-内酰胺）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型） ESBL（超广谱β-内酰胺酶） blaCTX-M-8+blaCTX-M-25 组基因 细菌性 细菌的 耐性 试样 贝塔 阻力

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