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Part Descriptions

LP182479-8   Porcine epidemic diarrhea virus
Porcine Epidemic Diarrhea Virus (PEDv) is a large-enveloped RNA virus, which is a member of the genus Alphacoronavirus within the Coronaviridae family. The complete PEDv genome consists of 5 gene segments: open reading frame 1 (ORF1), spike (S), envelope (E), membrane (M), and nucleocapsid (N). It is encapsulated by a single N protein. The S protein contributes to the stimulation of neutralizing antibodies in the infected host. Its association to adapted growth in vitro and attenuation in vivo lends itself to use for genetic comparison among PEDV isolates and effective vaccines. The M protein is required for assembly and can also induce the production of virus-neutralizing antibodies. The E protein contributes to coronavirus budding. The N protein has functions associated with viral replication and pathogenesis.
PEDv causes viral enteritis, which leads to the destruction of villus enterocytes in pigs of all ages. It is spread by the ingestion of feces from infected pigs, resulting in vomiting, watery diarrhea, dehydration, and high mortality, especially in nursery piglets. Disease caused by PEDv is clinically similar to that caused by Transmissible gastroenteritis coronavirus (TGEV) PMID: 26689811
At least two PEDv strains have been identified in the USA: the US PEDv prototype and S INDEL variant. The INDEL variant PEDv strain has insertions and deletions (INDELs) in the spike (S) gene. PMID: 25279722 The INDEL strain is related to milder clinical signs than prototype strains. PMID: 24750580 PMID: 26748596 The genomic differences in the S gene between the US PEDv prototype and INDEL variant may be responsible for the virulence differences. Potential targets when testing for PEDv RNA include the nucleocapsid protein (N) gene and the ~2500 bp fragment of the S-gene. Source: Regenstrief LOINC

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Porcine epidemic diarrhea virus Ab.Neut:Titr:Pt:Ser:SemiQn:Neut
Long Common Name
Porcine epidemic diarrhea virus neutralizing antibody [Titer] in Serum by Neutralization test
Short Name
PEDv NAb Titr Ser Nt
Display Name
Porcine epidemic diarrhea virus neut ab Neut test (S) [Titer]
Consumer Name Alpha Get Info
Porcine Epidemic Diarrhea virus neutralizing antibody, Blood

Part Model Get Info

  • Component
    Porcine epidemic diarrhea virus Ab.Neut
    LP249854-3
    • Analyte
      Porcine epidemic diarrhea virus Ab.Neut
      LP249854-3
      • Component Numerator
        Porcine epidemic diarrhea virus Ab.Neut
        LP249854-3
        • Component Numerator Core
          Porcine epidemic diarrhea virus
          LP182479-8
        • Component Numerator Core Suffix
          Ab.Neut
          LP207365-0
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Titr
    LP6881-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    SemiQn
    LP436123-6
  • Method
    Neut
    LP6416-4

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.75 (MAJ)
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Virus epidemické prasečí průjmové nemoci (PED) Ab neutralizační:Arbitrární koncentrace (titr):Časový bod:Sérum:Semikvantitativní:Neutralizační test
el-GRGreek (Greece)Ιός επιδημικής διάρροιας των χοίρων Ab.Neut:Titr:Pt:Ορός:Ημιποσοτική:Ουδετερόφιλα
Synonyms: Ab.Neut MICRO Pt Titr Αντίσωμα Ημιποσοτική Ιός Ιός επιδημικής διάρροιας των χοίρων Ορός Ουδετερόφιλα Των χοίρων
es-ESSpanish (Spain)Virus de la diarrea epidémica porcina Anticuerpos antineutrófilos:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:Prueba de neutralización
Synonyms: Semicuantitativo
es-MXSpanish (Mexico)Virus de la diarrea epidémica porcina Ab.Neut:Título:Punto temporal:Suero:Cuantitativo:Prueba de neutralización
it-ITItalian (Italy)Virus della diarrea epidemica suina Ab.Neut:Titr:Pt:Siero:SemiQn:Neut
Synonyms: anticorpo Microbiologia Punto nel tempo (episodio) Siero Test di neutralizzazione Titolo Virus PED
nl-NLDutch (Netherlands)'porcine' epizoötisch diarreevirus As.neutraliserend:titer:moment:serum:semikwantitatief:neutralisatietest
Synonyms: antistof; antilichaam epizoötisch diarreevirus van varken porcine
pl-PLPolish (Poland)Wirus epidemicznej biegunki świń Ab.Neutralizujące:miano:punkt w czasie:surowica:półilościowy:test neutralizacji
zh-CNChinese (China)猪流行性腹泻病毒 抗体.中和:滴定度:时间点:血清:半定量型:中和试验
Synonyms: Ab;自身抗体 下痢;泄泻;下利;泻肚 中和试验;中和抗体;中和 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 猪传染性腹泻病毒;PEDv 猪的 猪科 猪科的

Example Units

UnitSource
{titer}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86216-9