86239-1

Cells.chromosome 3 monosomy/Cells counted in Cancer specimen by FISH

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Term Description

The percent of cells in the cancer specimen containing a single copy of chromosome 3 (monosomy 3) can be detected by FISH based on the number of chromosome 3 probe signals. This term is used to report the number of cells that have a chromosome 3 deletion out of total number of cells examined (e.g. 80 or of 100 cells, or 80%). Results are also typically reported in ISCN (International System for Human Cytogenetic Nomenclature) format LOINC 62356-1. This term was created for, but not limited in use to, the submitter's assay which uses the Vysis chromosome 3 CEP (D3Z1) probe and a laboratory-developed BCL6 (3q27.2) probe.

Part Descriptions

LP249031-8 Cells.chromosome 3 monosomy
Ocular melanoma is a rare cancer of the pigment cells in the eye. The most common ocular melanoma of adults is uveal melanoma. The uvea is the middle layer of the eye between the sclera and the retina. Uveal melanoma can be difficult to treat due to the lack of early signs or symptoms of disease. (https://www.aao.org/eye-health/diseases/ocular-melanoma-diagnosis) The incidence of uveal melanoma in the adult Caucasian population is about 0.7 cases per 100,000 per year. Due to the lack of early signs and symptoms and consequent delay in treatment, metastatic disease is common and occurs in up to half of all patients. In one study of patients with uveal melanoma, 62% of the melanoma specimens were positive for chromosome 3 monosomy (monosomy 3), and the finding of monosomy 3 was correlated with both the likelihood of metastatic disease as well as decreased survival. The underlying reason for the association between chromosome 3 monosomy and metastases is not yet understood. PMID: 18234992 Source: Regenstrief LOINC

LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

LOINC Names Get Info

Fully-Specified Name: Cells.chromosome 3 monosomy/cells counted:NFr:Pt:Cancer specimen:Qn:FISH
Long Common Name: Cells.chromosome 3 monosomy/Cells counted in Cancer specimen by FISH
Short Name: Cells.chr 3 mono/Cells NFr Ca spec FISH
Display Name: Cells.chromosome 3 monosomy/Cells counted FISH (Cancer specimen)
Consumer Name Alpha Get Info: Cells.chromosome 3 monosomy/Cells Counted, Cancer specimen

Part Model Get Info

Component
Cells.chromosome 3 monosomy/cells counted
LP285639-3
- Analyte
  Cells.chromosome 3 monosomy/cells counted
  LP285639-3
  - Component Numerator
    Cells.chromosome 3 monosomy
    LP249031-8
    - Component Numerator Core
      Cells.chromosome 3 monosomy
      LP249031-8
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Cells counted
    LP190810-4
    - Component Denominator Core
      Cells counted
      LP190810-4
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
NFr
LP6838-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Cancer specimen
LP247830-5
- System Core
  Cancer specimen
  LP247830-5
- Super System
  NULL
Scale
Qn
LP7753-9
Method
FISH
LP62864-1

Basic Attributes

Class: MOLPATH.DELDUP
Type: Laboratory
First Released: Version 2.61
Last Updated: Version 2.61 (ADD)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Buňky.chromozom 3 monozomie/buňky spočítané:Početní podíl:Časový bod:Vzorek karcinomu:Kvantitativní:Fluorescenční in situ hybridizace (FISH)
el-GR	Greek (Greece)	Κύτταρα.μονοσωμία χρωμοσώματος 3/Μετρηθέντα κύτταρα:NFr:Pt:Δείγμα καρκίνου:Qn:Φθορίζουσα υβριδοποίηση in situ Synonyms: MOLPATH MOLPATH.DELDUP NFr Pt Qn Δείγμα Δείγμα καρκίνου Καρκίνος Κύτταρα Κύτταρα.μονοσωμία χρωμοσώματος 3 Μετρηθέντα κύτταρα Φθορίζουσα υβριδοποίηση in situ Χρωμόσωμα
es-ES	Spanish (Spain)	Celulas.Monosomía del cromosoma 3./Contaje celular:Fracción numérica:Punto temporal:Muestra de cancer:Qn:Hibridación in situ fluoresente (FISH) Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Cells.cromosoma 3 monosomía / células contadas:Fracción numérica:Punto temporal:Espécimen de cáncer:Cuantitativo:Hibridación fluorescente in situ (FISH)
fr-FR	French (France)	Chromosome 3 monosomie/cellules comptées:Fraction de nombres:Ponctuel:Tissu cancereux:Numérique:FISH
it-IT	Italian (Italy)	Cellule.monosomia cromosoma 3/Cellule contate:NFr:Pt:Campione tumore:Qn:FISH Synonyms: Campione di tumore Delezione o duplicazione genica Frazione numerica Ibridazione in situ fluorescente (FISH) Neoplasia maligna Patologia molecolare Punto nel tempo (episodio)
pl-PL	Polish (Poland)	Komórki.Chromosom 3 - monosomia/zliczone komórki:frakcja liczbowa:punkt w czasie:próbka nowotworu:ilościowy:FISH Synonyms: fluorescencyjna hybrydyzacja in situ Komórki z monosomią chromosomu 3 Komórki z monosomią chromosomu 3 w stosunku do zliczonych komórek nowotwór
zh-CN	Chinese (China)	细胞.染色体 3 单体性/已计数的细胞:计数型分数:时间点:癌标本:定量型:FISH Synonyms: Ⅲ Fluorescent in situ hybridization;荧光原位杂交 III 三供检查用的材料;待检物;待试验物;样品;样本;试料;试样分子病理学;分子病理学试验叁受检物可用数量表示的;定量性;数值型;数量型;连续数值型标尺所计数的细胞;计数细胞;所计数细胞;已计数细胞所计数细胞;已计数过细胞;已计数细胞;已计过数细胞数量型分数;数量或计数型分数;数量型分数或计数型分数时刻;随机;随意;瞬间染色体二体型+染色体三体型样品样本癌癌（癌症、癌变）标本（样本、样品、试样）细胞.3 号染色体单体性细胞含量;细胞性;细胞性质;细胞构成;细胞类试样

Example Units

Unit	Source
%	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.