Version 2.77

Term Description

The percent of cells in the cancer specimen containing a single copy of chromosome 3 (monosomy 3) can be detected by FISH based on the number of chromosome 3 probe signals. This term is used to report the number of cells that have a chromosome 3 deletion out of total number of cells examined (e.g. 80 or of 100 cells, or 80%). Results are also typically reported in ISCN (International System for Human Cytogenetic Nomenclature) format [LOINC: 62356-1]. This term was created for, but not limited in use to, the submitter's assay which uses the Vysis chromosome 3 CEP (D3Z1) probe and a laboratory-developed BCL6 (3q27.2) probe.
Source: Regenstrief LOINC

Part Descriptions

LP249031-8   Cells.chromosome 3 monosomy
Ocular melanoma is a rare cancer of the pigment cells in the eye. The most common ocular melanoma of adults is uveal melanoma. The uvea is the middle layer of the eye between the sclera and the retina. Uveal melanoma can be difficult to treat due to the lack of early signs or symptoms of disease. (https://www.aao.org/eye-health/diseases/ocular-melanoma-diagnosis) The incidence of uveal melanoma in the adult Caucasian population is about 0.7 cases per 100,000 per year. Due to the lack of early signs and symptoms and consequent delay in treatment, metastatic disease is common and occurs in up to half of all patients. In one study of patients with uveal melanoma, 62% of the melanoma specimens were positive for chromosome 3 monosomy (monosomy 3), and the finding of monosomy 3 was correlated with both the likelihood of metastatic disease as well as decreased survival. The underlying reason for the association between chromosome 3 monosomy and metastases is not yet understood. PMID: 18234992 Source: Regenstrief LOINC

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

Fully-Specified Name

Component
Cells.chromosome 3 monosomy/cells counted
Property
NFr
Time
Pt
System
Cancer specimen
Scale
Qn
Method
FISH

Additional Names

Short Name
Cells.chr 3 mono/Cells NFr Ca spec FISH
Display Name
Cells.chromosome 3 monosomy/Cells counted FISH (Cancer specimen)
Consumer Name Alpha Get Info
Cells.chromosome 3 monosomy/Cells Counted, Cancer specimen

Basic Attributes

Class
MOLPATH.DELDUP
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.61
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Celulas.Monosomía del cromosoma 3./Contaje celular:Fracción numérica:Punto temporal:Muestra de cancer:Qn:Hibridación in situ fluoresente (FISH)
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Cells.cromosoma 3 monosomía / células contadas:Fracción numérica:Punto temporal:Espécimen de cáncer:Cuantitativo:Hibridación fluorescente in situ (FISH)
fr-FR French (France) Chromosome 3 monosomie %:Fraction de nombres:Ponctuel:Tissu cancereux:Numérique:FISH
it-IT Italian (Italy) Cellule.monosomia cromosoma 3/Cellule contate:NFr:Pt:Campione tumore:Qn:FISH
Synonyms: Campione di tumore Delezione o duplicazione genica Frazione numerica Ibridazione in situ fluorescente (FISH) Neoplasia maligna Patologia molecolare Punto nel tempo (episodio)
pl-PL Polish (Poland) Komórki.Chromosom 3 - monosomia/zliczone komórki:frakcja liczbowa:punkt w czasie:próbka nowotworu:ilościowy:fluorescencyjna hybrydyzacja in situ (FISH)
Synonyms: Komórki z monosomią chromosomu 3 Komórki z monosomią chromosomu 3 w stosunku do zliczonych komórek
zh-CN Chinese (China) 细胞.染色体 3 单体性/已计数的细胞:计数型分数:时间点:癌标本:定量型:FISH
Synonyms: Ⅲ Fluorescent in situ hybridization;荧光原位杂交 III 三 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分子病理学;分子病理学试验 叁 受检物 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 所计数的细胞;计数细胞;所计数细胞;已计数细胞 所计数细胞;已计数过细胞;已计数细胞;已计过数细胞 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 染色体二体型+染色体三体型 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 细胞.3 号染色体单体性 细胞含量;细胞性;细胞性质;细胞构成;细胞类 试样

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86239-1