86698-8
Porcine epidemic diarrhea virus RNA [Nucleotide sequence] in Isolate by Sequencing
Active
Part Descriptions
LP150045-5 Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977. PMID: 271968 Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost. PMID: 18576944 Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template. PMID: 20858600
Source: Regenstrief LOINC
LP182479-8 Porcine epidemic diarrhea virus
Porcine Epidemic Diarrhea Virus (PEDv) is a large-enveloped RNA virus, which is a member of the genus Alphacoronavirus within the Coronaviridae family. The complete PEDv genome consists of 5 gene segments: open reading frame 1 (ORF1), spike (S), envelope (E), membrane (M), and nucleocapsid (N). It is encapsulated by a single N protein. The S protein contributes to the stimulation of neutralizing antibodies in the infected host. Its association to adapted growth in vitro and attenuation in vivo lends itself to use for genetic comparison among PEDV isolates and effective vaccines. The M protein is required for assembly and can also induce the production of virus-neutralizing antibodies. The E protein contributes to coronavirus budding. The N protein has functions associated with viral replication and pathogenesis.
PEDv causes viral enteritis, which leads to the destruction of villus enterocytes in pigs of all ages. It is spread by the ingestion of feces from infected pigs, resulting in vomiting, watery diarrhea, dehydration, and high mortality, especially in nursery piglets. Disease caused by PEDv is clinically similar to that caused by Transmissible gastroenteritis coronavirus (TGEV) PMID: 26689811
At least two PEDv strains have been identified in the USA: the US PEDv prototype and S INDEL variant. The INDEL variant PEDv strain has insertions and deletions (INDELs) in the spike (S) gene. PMID: 25279722 The INDEL strain is related to milder clinical signs than prototype strains. PMID: 24750580 PMID: 26748596 The genomic differences in the S gene between the US PEDv prototype and INDEL variant may be responsible for the virulence differences. Potential targets when testing for PEDv RNA include the nucleocapsid protein (N) gene and the ~2500 bp fragment of the S-gene.
Source: Regenstrief LOINC
LOINC Names Get Info
- Fully-Specified Name
- Porcine epidemic diarrhea virus RNA:
Seq: Pt: Isolate: Nom: Sequencing - Long Common Name
- Porcine epidemic diarrhea virus RNA [Nucleotide sequence] in Isolate by Sequencing
- Short Name
- PEDv RNA Islt-Seq
- Display Name
- Porcine epidemic diarrhea virus RNA sequence Nom (Isol)
- Consumer Name Alpha Get Info
- Porcine Epidemic Diarrhea virus
Part Model Get Info
- Component
- Porcine epidemic diarrhea virus RNA
LP182480-6
- Analyte
- Porcine epidemic diarrhea virus RNA
LP182480-6
- Component Numerator
- Porcine epidemic diarrhea virus RNA
LP182480-6
- Component Numerator Core
- Porcine epidemic diarrhea virus
LP182479-8
- Component Numerator Core Suffix
- RNA
LP32423-3
- Component Denominator
- NULL
- Component Denominator Core
- NULL
- Component Denominator Core Suffix
- NULL
- Challenge
- NULL
- Adjustment
- NULL
- Count
- NULL
- Property
- Seq
LP62164-6
- Time
- Pt
LP6960-1
- Time Core
- Pt
LP6960-1
- Time Modifier
- NULL
- System
- Isolate
LP7370-2
- System Core
- Isolate
LP7370-2
- Super System
- NULL
- Scale
- Nom
LP7750-5
- Method
- Sequencing
LP150045-5
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.61
- Last Updated
- Version 2.61 (ADD)
- Order vs. Observation
- Observation
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Virus epidemické prasečí průjmové nemoci (PED) RNA: |
| el-GR | Greek (Greece) | Ιός επιδημικής διάρροιας των χοίρων RNA: Synonyms: MICRO Nom Pt RNA Seq Αλληλούχιση Απομονωμένο στέλεχος Ιός Ιός επιδημικής διάρροιας των χοίρων Των χοίρων |
| es-ES | Spanish (Spain) | Virus de la diarrea epidémica porcina RNA: |
| es-MX | Spanish (Mexico) | ARN del virus de la diarrea epidémica porcina: |
| it-IT | Italian (Italy) | Virus della diarrea epidemica suina RNA: Synonyms: Microbiologia Punto nel tempo (episodio) Sequenza nucleotidica Virus PED |
| nl-NL | Dutch (Netherlands) | 'porcine' epizoötisch diarreevirus RNA: Synonyms: epizoötisch diarreevirus van varken porcine |
| pl-PL | Polish (Poland) | Wirus epidemicznej biegunki świń RNA: Synonyms: wynik kategorialny |
| tr-TR | Turkish (Turkey) | Porsin epidemik diyare virüsü RNA: Synonyms: Dizi tayini Sekans |
| zh-CN | Chinese (China) | 猪流行性腹泻病毒 RNA: Synonyms: 下痢; |
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://