86863-8
Dengue virus 3 neutralizing antibody [Presence] in Specimen by Neutralization test
Active
Term Description
Qualitative result for Dengue virus 3 neutralizing antibodies in clinical specimens. Serological cross-reactivity is strong between Dengue and other flaviviruses, especially Zika virus. Therefore, positive EIA or IF assays are presumptive only and should be confirmed by a neutralization assay, such as the plaque-reduction neutralization test (PRNT), which can discriminate between Dengue virus and cross-reacting antibodies in primary flavivirus infections.
Source: Regenstrief LOINC
Part Descriptions
LP207365-0 Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method.
Source: Regenstrief LOINC
LP6416-4 Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Dengue virus 3 Ab.Neut
- Property
- PrThr
- Time
- Pt
- System
- XXX
- Scale
- Ord
- Method
- Neut
Additional Names
- Short Name
- DENV3 NAb Spec Ql Nt
- Display Name
- DENV 3 neut ab Neut test Ql (Specimen)
- Consumer Name Alpha Get Info
- Dengue virus 3 neutralizing antibody, Specimen
Example Answer List: LL2009-0
Source: ARUP Laboratories| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 | ||
| EquivocalCopyright http://snomed.info/sct ID:42425007 Equivocal (qualifier value) | LA11885-3 |
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.61
- Last Updated
- Version 2.69
- Order vs. Observation
- Both
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG32760-7 | Dengue virus |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Dengue-Virus 3 Ak.neutralisierend: |
| es-ES | Spanish (Spain) | Virus Dengue 3 Anticuerpos antineutrófilos: |
| es-MX | Spanish (Mexico) | Virus del dengue 3 Ab.Neut: |
| fr-FR | French (France) | Dengue virus 3 Ac neutralisant: |
| fr-CA | French (Canada) | Virus de la dengue 3 Ac.neut: |
| it-IT | Italian (Italy) | Dengue virus 3 Ab.Neut: Synonyms: anticorpo Microbiologia Presenza o Soglia Punto nel tempo (episodio) Test di neutralizzazione |
| nl-NL | Dutch (Netherlands) | Denguevirus 3 As.neutraliserend: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Wirus dengi 3 Ab.Neutralizujące: Synonyms: Przeciwciała do wirusa dengi 3 Przeciwciała neutraliziujące do wirusa dengi 3 Wirus dengi Wirus dengi 3 |
| zh-CN | Chinese (China) | 登革热病毒 3 型 抗体.中和: Synonyms: Ⅲ Ab; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=86863-8
Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright