86864-6

Dengue virus 2 neutralizing antibody [Presence] in Specimen by Neutralization test

Active

Term Description

Qualitative result for Dengue virus 2 neutralizing antibodies in clinical specimens. Serological cross-reactivity is strong between Dengue and other flaviviruses, especially Zika virus. Therefore, positive EIA or IF assays are presumptive only and should be confirmed by a neutralization assay, such as the plaque-reduction neutralization test (PRNT), which can discriminate between Dengue virus and cross-reacting antibodies in primary flavivirus infections.

Part Descriptions

LP207365-0 Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP6416-4 Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Dengue virus 2 Ab.Neut:PrThr:Pt:XXX:Ord:Neut
Long Common Name: Dengue virus 2 neutralizing antibody [Presence] in Specimen by Neutralization test
Short Name: DENV2 NAb Spec Ql Nt
Display Name: DENV 2 neut ab Neut test Ql (Specimen)
Consumer Name Alpha Get Info: Dengue virus 2 neutralizing antibody, Specimen

Part Model Get Info

Component
Dengue virus 2 Ab.Neut
LP248354-5
- Analyte
  Dengue virus 2 Ab.Neut
  LP248354-5
  - Component Numerator
    Dengue virus 2 Ab.Neut
    LP248354-5
    - Component Numerator Core
      Dengue virus 2
      LP17692-2
    - Component Numerator Core Suffix
      Ab.Neut
      LP207365-0
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
XXX
LP7735-6
- System Core
  XXX
  LP7735-6
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Neut
LP6416-4

Example Answer List: LL2009-0

Source: ARUP Laboratories

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6
EquivocalCopyright http://snomed.info/sct ID:42425007 Equivocal (qualifier value)			LA11885-3

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.61
Last Updated: Version 2.69 (MIN)
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG32760-7	Dengue virus

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Virus horečky dengue 2 Ab neutralizační:Přítomnost nebo práh:Časový bod:XXX:Ordinální:Neutralizační test
de-DE	German (Germany)	Dengue-Virus 2 Ak.neutralisierend:Nachweis oder Schwellenwert:Zeitpunkt:XXX:Ordinal:Neutralisationstest
el-GR	Greek (Greece)	Ιός δάγγειου πυρετού 2 Ab.Neut:PrThr:Pt:XXX:Ord:Ουδετερόφιλα Synonyms: Ab.Neut MICRO Ord PrThr Pt XXX Αντίσωμα Ιός Ιός δάγγειου πυρετού Ιός δάγγειου πυρετού 2 Ουδετερόφιλα
es-ES	Spanish (Spain)	Virus Dengue 2 Anticuerpos antineutrófilos:PrThr:Punto temporal:XXX:Ord:Prueba de neutralización
es-MX	Spanish (Mexico)	Virus del dengue 2 Ab.Neut:Presencia o umbral:Punto temporal:XXX:Ordinal:Prueba de neutralización
fr-FR	French (France)	Dengue virus 2 Ac neutralisant:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:Neutralisation
fr-CA	French (Canada)	Virus de la dengue 2 Ac.neut:Présence-Seuil:Temps ponctuel:XXX:Ordinal:Test de neutralisation
it-IT	Italian (Italy)	Dengue virus 2 Ab.Neut:PrThr:Pt:XXX:Ord:Neut Synonyms: anticorpo Microbiologia Presenza o Soglia Punto nel tempo (episodio) Test di neutralizzazione
nl-NL	Dutch (Netherlands)	Denguevirus 2 As.neutraliserend:aanwezigheid:moment:XXX:ordinaal:neutralisatietest Synonyms: antistof; antilichaam
pl-PL	Polish (Poland)	Wirus dengi 2 Ab.Neutralizujące:granica wykrywalności:punkt w czasie:XXX:uporządkowany:test neutralizacji Synonyms: Przeciwciała do wirusa dengi 2 Przeciwciała neutralziujące do wirusa dengi 2 Wirus dengi Wirus dengi 2
zh-CN	Chinese (China)	登革热病毒 2 型抗体.中和:存在情况或阈值:时间点:XXX:序数型:中和试验 Synonyms: Ⅱ Ab;自身抗体 DENV 2 Ab DENV 2 抗体 DENV 2;DENV II;DENV2;登革热;登革热病毒 II 型 DENV II Ab DENV II 抗体 DENV;地方性蔷薇疹热;登革热;登革病毒;黄病毒 DENV2 Ab DENV2 抗体 II 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项中和试验;中和抗体;中和传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）时刻;随机;随意;瞬间登革热病毒 2 型 Ab 登革热病毒 II 型 Ab 登革热病毒 II 型抗体

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86864-6

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to https://www.snomed.org/get-snomed or [email protected]<mailto:[email protected]>. This may incur a fee in SNOMED International non-Member countries.

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.