86896-8

inFLIXimab [Mass/volume] in Serum or Plasma by Immunoassay

Active

Term Description

This term was created for, but not limited in use to, the submitter's Theradiag Lisa-Tracker Infliximab and anti-Infliximab test kits.

Part Description

LP35095-6 inFLIXimab
Infliximab is a genetically engineered immunoglobulin 1 murine-human chimeric monoclonal antibody against tumor necrosis factor alpha (TNFα). The murine portion is the part of the antibody that binds to TNFα while the human portion preserves functional immune capacity. Infliximab is used to treat Crohn's disease and, in particular, in treating the closure of intestinal or perianal fistulas in patients with acute intestinal involvement who have been unresponsive to other treatments. TNFα is a cytokine that acts to increase the inflammatory process in CD, RA, psoriasis and spondylarthropathy. The primary mechanism of infliximab is to combine with the inactivate soluble transmembrane TNFα. However, infliximab also modulates TNFα-producing cells through complement fixation of antibody-dependent T lymphocytes and monocytes by binding them to the IgG1 fc portion of infliximab. There is also a subsequent down-regulation of other inflammation-producing cytokines and a reduction of the level of chemokines and endothelial adhesion molecules. Negative side effects of infliximab include fibrostenosing CD and sepsis. PMID: 18360638 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: inFLIXimab:MCnc:Pt:Ser/Plas:Qn:IA
Long Common Name: inFLIXimab [Mass/volume] in Serum or Plasma by Immunoassay
Short Name: inFLIXimab SerPl IA-mCnc
Display Name: inFLIXimab IA [Mass/Vol]
Consumer Name Alpha Get Info: inFLIXimab, Blood

Part Model Get Info

Component
inFLIXimab
LP35095-6
- Analyte
  inFLIXimab
  LP35095-6
  - Component Numerator
    inFLIXimab
    LP35095-6
    - Component Numerator Core
      inFLIXimab
      LP35095-6
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas
LP7576-4
- System Core
  Ser/Plas
  LP7576-4
- Super System
  NULL
Scale
Qn
LP7753-9
Method
IA
LP217197-5

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.63
Last Updated: Version 2.63 (ADD)
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG16182-4	Infliximab\|MCnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
ar-JO	Arabic (Jordan)	الإنفلكسيماب " ريميكيد " في المصل أو البلازما ( الكتلة / الحجم ) ( بتقنية المقايسة المناعية )
cs-CZ	Czech (Czechia)	Infliximab:Hmotnostní koncentrace:Časový bod:Sérum/plazma:Kvantitativní:Imunoanalýza
el-GR	Greek (Greece)	Ινφλιξιμάμπη:MCnc:Pt:Ορός/Πλάσμα:Qn:IA Synonyms: DRUG/TOX IA MCnc Pt Qn Ινφλιξιμάμπη Ορός Ορός/Πλάσμα Πλάσμα
es-ES	Spanish (Spain)	Infliximab:Concentración de masa:Punto temporal:Suero o Plasma:Qn:IA Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	inFLIXimab:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
et-EE	Estonian (Estonia)	Infliksimaab:MCnc:Pt:S/P:Qn:IA Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA	French (Canada)	Infliximab:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
fr-FR	French (France)	Infliximab:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
fr-BE	French (Belgium)	Infliximab:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
it-IT	Italian (Italy)	Infliximab:MCnc:Pt:Siero/Plasma:Qn:IA Synonyms: Concentrazione di Massa Immunoassay Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL	Dutch (Netherlands)	infliximab:massa/volume:moment:serum of plasma:kwantitatief:immunoassay Synonyms: IA
pl-PL	Polish (Poland)	Infliksymab:stężenie masowe:punkt w czasie:surowica lub osocze:ilościowy:metoda immunologiczna
ru-RU	Russian (Russian Federation)	Инфликсимаб:МассКонц:ТчкВрм:Сыв/Плаз:Колич:IA Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR	Turkish (Turkey)	İnfliksimab:KütlKons:Zmlı:Ser/Plaz:Kant:İA Synonyms: İmmünölçüm, immünoassay
zh-CN	Chinese (China)	英利昔单抗:质量浓度:时间点:血清/血浆:定量型:免疫测定法 Synonyms: Infliximab 单抗;嵌合了肿瘤坏死因子α（TNF-α）的单克隆抗体;目前主要用于治疗类风湿性关节炎（RA）和克隆病（CD）;英利昔;英利昔单克隆抗体;因福利美;抗炎单克隆抗体免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间毒品毒品类水平;浓度;质量浓度(单位体积) 药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类血清或血浆

Example Units

Unit	Source
ng/mL	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.