LOINC
Version 2.73

87320-8Escherichia coli enterotoxigenic heat-labile toxin DNA [Presence] in Isolate by NAA with probe detectionActive

Part Description

LP262496-5   Escherichia coli enterotoxigenic heat-labile toxin DNA
Enterotoxigenic Escherichia coli (ETEC) produces a heat-labile (LT) and a heat-stable (ST) enterotoxin, both of which cause severe diarrhea in both humans and animals. ST is an extracellular toxin which is comprised of a methanol-soluble (STa) toxin and a methanol-insoluble (STb) toxin. The sta gene encodes the STa toxin and the stb gene encodes the STb toxin. [UniProt:Q70Q79]; [UniProt:Q70Q73] STa combines to its enterocyte receptor, guanylate cyclase, which causes intestinal secretion and diarrhea.[PMID:8528070] The STb enterocyte receptor is the protein sulfatide. After STb binds to sulfatide, it is engulfed by the enterocyte. It then activates the pertussis toxin-sensitive G protein which opens the ligand-gated calcium ion channel, allowing an influx of calcium ions. A subsequent secretion of chloride ions, stimulation of arachidonic acid release, and production of prostaglandin E2 and 5-dyroxytryptamine leads to an efflux of water, bicarbonate ions, sodium ions, and chloride ions into the intestinal space, all of which leads to watery diarrhea.[PMID:23716609] Source: Regenstrief LOINC

Fully-Specified Name

Component
Escherichia coli enterotoxigenic heat-labile toxin DNA
Property
PrThr
Time
Pt
System
Isolate
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
ETEC heat-lab tox DNA Islt Ql NAA+probe
Display Name
E. coli enterotoxigenic heat-labile toxin DNA NAA+probe Ql (Isol)
Consumer Name Alpha
Escherichia coli enterotoxigenic heat-labile toxin

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.63
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
大肠埃希菌肠产毒素型不耐热性毒素 DNA:存在情况或阈值:时间点:分离株:序数型:探针法.基因扩增.靶向
nl-NLDutch (Netherlands)
Escherichia coli enterotoxine-gen panel DNA:aanwezigheid:moment:isolaat:ordinaal:moleculaire techniek (PCR)
fr-FRFrench (France)
Escherichia coli entérotoxinogène toxine thermolabile ADN:Présence/Seuil:Ponctuel:Isolat:Qualitatif:PCR amplification de cible
de-DEGerman (Germany)
Escherichia coli enterotoxigenes hitzelabiles Toxin DNA:Nachweis oder Schwellenwert:Zeitpunkt:Isolat:Ordinal:Zielfragmentamplifikation mit Sondendetektion
it-ITItalian (Italy)
Escherichia coli enterotossigeni, tossina termolabile DNA:PrThr:Pt:Isolato:Ord:Sonda.amp.tar
es-MXSpanish (Mexico)
ADN de toxina termolábil enterotoxigénica de Escherichia coli:Presencia o umbral:Punto temporal:Aislado:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ESSpanish (Spain)
Toxina termolábil Escherichia coli enterotoxigenico ADN:PrThr:Punto temporal:Aislado:Ord:Sonda con amplificación dirigida

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=87320-8