Version 2.77

Part Description

LP262495-7   Escherichia coli enterotoxigenic sta gene
Enterotoxigenic Escherichia coli (ETEC) produces a heat-labile (LT) and a heat-stable (ST) enterotoxin, both of which cause severe diarrhea in both humans and animals. ST is an extracellular toxin which is comprised of a methanol-soluble (STa) toxin and a methanol-insoluble (STb) toxin. The sta gene encodes the STa toxin and the stb gene encodes the STb toxin. [UniProt: Q70Q79]; [UniProt: Q70Q73] STa combines to its enterocyte receptor, guanylate cyclase, which causes intestinal secretion and diarrhea. PMID: 8528070 The STb enterocyte receptor is the protein sulfatide. After STb binds to sulfatide, it is engulfed by the enterocyte. It then activates the pertussis toxin-sensitive G protein which opens the ligand-gated calcium ion channel, allowing an influx of calcium ions. A subsequent secretion of chloride ions, stimulation of arachidonic acid release, and production of prostaglandin E2 and 5-dyroxytryptamine leads to an efflux of water, bicarbonate ions, sodium ions, and chloride ions into the intestinal space, all of which leads to watery diarrhea. PMID: 23716609 Source: Regenstrief LOINC

Fully-Specified Name

Component
Escherichia coli enterotoxigenic sta gene
Property
PrThr
Time
Pt
System
Isolate
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
ETEC sta gene Islt Ql NAA+probe
Display Name
E. coli enterotoxigenic sta gene NAA+probe Ql (Isol)
Consumer Name Alpha Get Info
Escherichia coli enterotoxigenic sta gene

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.63
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
88125-0 Escherichia coli enterotoxigenic gene panel - Specimen by NAA with probe detection

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Escherichia coli enterotoxigenic sta-Gen:Nachweis oder Schwellenwert:Zeitpunkt:Isolat:Ordinal:Zielfragmentamplifikation mit Sondendetektion
es-ES Spanish (Spain) Gen sta Escherichia coli enterotoxigenico:PrThr:Punto temporal:Aislado:Ord:Sonda con amplificación dirigida
es-MX Spanish (Mexico) Gen sta enterotoxigénico de Escherichia coli:Presencia o umbral:Punto temporal:Aislado:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Escherichia coli entérotoxinogène sta gène:Présence/Seuil:Ponctuel:Isolat:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Escherichia coli enterotossigeni gene sta:PrThr:Pt:Isolato:Ord:Sonda.amp.tar
Synonyms: ETEC Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL Dutch (Netherlands) Escherichia coli enterotoxine-gen hittegevoelig toxine:aanwezigheid:moment:isolaat:ordinaal:probe-detectie
Synonyms: E.coli; EAEC probe.amp.tar
zh-CN Chinese (China) 大肠埃希菌肠产毒素型 sta 基因:存在情况或阈值:时间点:分离株:序数型:探针法.基因扩增.靶向
Synonyms: E coli;大肠埃希氏杆菌;大肠埃希氏菌;大肠杆菌 产肠毒素性大肠埃希菌（E coli、大肠埃希氏杆菌、大肠埃希氏菌、大肠杆菌）;肠毒性大肠杆菌;肠产毒性大肠杆菌;ETEC 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 分离物;分离菌;分离菌株;隔离种群 大肠埃希菌（E coli、大肠埃希氏杆菌、大肠埃希氏菌、大肠杆菌）肠产毒素型（肠产毒素性、产肠毒素性、产肠毒素型、肠毒性、肠毒型、产肠毒性、产肠毒型） sta 基因 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 遗传基因;遗传因子;吉恩;生物基因

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=87321-6