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Part Descriptions

LP263674-6   Cells.CD4-CD8-CD45R+TCR alpha beta+
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder that occurs when a mutation in the FAS gene prevents the normal death cycle of the lymphocytic white blood cells. The abnormal accumulation of non-malignant lymphocytes can lead to splenomegaly, lymphadenopathy, an increased risk of malignancy, and an autoimmune cytopenia resulting in anemia and thrombocytopenia. In ALPS there is an increase in the CD4- CD8- TCR alpha beta+ T cells, FAS ligand (FAS-L), and IL-10 protein. CD4-CD8- T cells are also known as double negative T cells (DNT). The expression of an atypical isoform of CD45 called CD45R (also known as B220) on CD4-CD8-TCR alpha beta+ T cells is sensitive and specific for ALPS. PMID: 19176318 PMID: 11513545 Source: Regenstrief LOINC

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Cells.CD4-CD8-CD45R+TCR alpha beta+/Cells.CD3:NFr:Pt:Bld:Qn:Flow cytometry
Long Common Name
Cells.CD4-CD8-CD45R+TCR alpha beta+/Cells.CD3 in Blood by Flow cytometry (FC)
Short Name
Cells.DNT-CD45R+TCR A-B+/CD3 Bld FC
Display Name
Cells.TCR alpha beta+DNT B220+/Cells.CD3 FC (Bld)
Consumer Name Alpha Get Info
Cells.TCR Alpha Beta+DNT B220+/Cells.CD3, Blood

Part Model Get Info

  • Component
    Cells.CD4-CD8-CD45R+TCR alpha beta+/Cells.CD3
    LP445247-2
    • Analyte
      Cells.CD4-CD8-CD45R+TCR alpha beta+/Cells.CD3
      LP445247-2
      • Component Numerator
        Cells.CD4-CD8-CD45R+TCR alpha beta+
        LP263674-6
        • Component Numerator Core
          Cells.CD4-CD8-CD45R+TCR alpha beta+
          LP263674-6
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        Cells.CD3
        LP436242-4
        • Component Denominator Core
          Cells.CD3
          LP436242-4
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    NFr
    LP6838-9
  • Time
    Pt
    LP6960-1
  • System
    Bld
    LP7057-5
    • System Core
      Bld
      LP7057-5
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    Flow cytometry
    LP6274-7

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.79 (NAM)
Change Reason
Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
101414-1Lymphocyte TCR alpha beta double negative subsets panel - Blood

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Buňky.CD4-CD8-CD45R+TCR alfa beta+/100 buněk.CD3:Početní podíl:Časový bod:Krev:Kvantitativní:Průtoková cytometrie
el-GRGreek (Greece)Κύτταρα.CD4-CD8-CD45R+TCR α β+/Κύτταρα.CD3:NFr:Pt:Αίμα:Qn:Κυτταρομετρία ροής
Synonyms: CD3 CD4 CD8 CELLMARK NFr Pt Qn TCR α β Αίμα Κύτταρα Κύτταρα.CD3 Κύτταρα.CD4 Κύτταρα.CD4+CD8+ Κύτταρα.CD4-CD8- Κύτταρα.CD4-CD8-CD45R+TCR α β+ Κυτταρομετρία ροής
es-MXSpanish (Mexico)Células CD4-CD8-CD45R + TCR alfa beta + / 100 células CD3:Fracción numérica:Punto temporal:Sangre:Cuantitativo:Citometría de flujo (FC)
es-ESSpanish (Spain)células.CD4-CD8-CD45R+TCR alfa beta+/Células CD3:Fracción numérica:Punto temporal:Sangre:Qn:Citometria de flujo (FC)
Synonyms: Cuantitativo
fr-FRFrench (France)CD4-CD8-CD45RA+TCR alpha bêta+/CD3+:Fraction de nombres:Ponctuel:Sang:Numérique:Cytométrie de flux
it-ITItalian (Italy)Cellule.CD4-CD8-CD45R+TCR alpha beta+/Cellule.CD3:NFr:Pt:Sangue:Qn:Citometria a flusso
Synonyms: Cellule CD3 Cellule CD4 Cellule CD4+CD8+ Citometria a flusso (FC) Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
pl-PLPolish (Poland)Komórki.CD4-CD8-CD45R+TCR alfa beta+/komórki.CD3:frakcja liczbowa:punkt w czasie:krew:ilościowy:cytometria przepływowa (FC)
Synonyms: CD4 CD8 komórki CD3 Komórki CD4 Komórki CD4+CD8+ Komórki CD4-CD8- Komórki CD4-CD8-CD45R+TCR alfa beta+ Receptor komórek T alfa beta
zh-CNChinese (China)细胞.CD4-CD8-CD45R+TCR alpha beta+/细胞.CD3:计数型分数:时间点:全血:定量型:流式细胞测量术
Synonyms: B CD3细胞 CD4+CD8+细胞 CD4细胞 L3T4 Leu2 Leu-2 Leu3 Leu-3 Leu4;Leu-4;T3 T 细胞受体 A-B;T 细胞受体 alpha beta;T 细胞受体 α-β;TcR A-B;TcR α-β T4 T-4 T8 T-8 Tsuppressor W3/25 α β 动态 发现于 抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 抑制性 T 细胞 抑制性 T-细胞 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 细胞.CD4-CD8-CD45R+TCR αβ+;细胞.CD4-CD8-CD45R+T细胞受体αβ+;细胞.CD4-CD8-CD45R+T-细胞受体αβ+ 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液 诱导 T 细胞 诱导性 T 细胞 贝塔 辅助 T 细胞 辅助诱导 T 细胞 辅助诱导物 T 细胞 阿尔法

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88052-6