Version 2.78

Part Descriptions

LP263674-6   Cells.CD4-CD8-CD45R+TCR alpha beta+
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder that occurs when a mutation in the FAS gene prevents the normal death cycle of the lymphocytic white blood cells. The abnormal accumulation of non-malignant lymphocytes can lead to splenomegaly, lymphadenopathy, an increased risk of malignancy, and an autoimmune cytopenia resulting in anemia and thrombocytopenia. In ALPS there is an increase in the CD4- CD8- TCR alpha beta+ T cells, FAS ligand (FAS-L), and IL-10 protein. CD4-CD8- T cells are also known as double negative T cells (DNT). The expression of an atypical isoform of CD45 called CD45R (also known as B220) on CD4-CD8-TCR alpha beta+ T cells is sensitive and specific for ALPS. PMID: 19176318 PMID: 11513545 Source: Regenstrief LOINC

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD4-CD8-CD45R+TCR alpha beta+/100 cells.CD3
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method
Flow cytometry

Additional Names

Short Name
Cells.DNT-CD45R+TCR A-B+/100 CD3 Bld FC
Display Name
Cells.TCR alpha beta+DNT B220+/100 CD3 cells FC (Bld)
Consumer Name Alpha Get Info
Cells.TCR Alpha Beta+DNT B220+ per 100 CD3 Cells, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.63
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
101414-1 Lymphocyte TCR alpha beta double negative subsets panel - Blood

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) células.CD4-CD8-CD45R+TCR alfa beta+/Linfocitos CD3:Fracción numérica:Punto temporal:Sangre:Qn:Citometria de flujo (FC)
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Células CD4-CD8-CD45R + TCR alfa beta + / 100 células CD3:Fracción numérica:Punto temporal:Sangre:Cuantitativo:Citometría de flujo (FC)
fr-FR French (France) CD4-CD8-CD45RA+TCR alpha bêta+/100 cellules CD3+:Fraction de nombres:Ponctuel:Sang:Numérique:Cytométrie de flux
it-IT Italian (Italy) Cellule.CD4-CD8-CD45R+TCR alpha beta+/Cellule.CD3:NFr:Pt:Sangue:Qn:Citometria a flusso
Synonyms: Cellule CD3 Cellule CD4 Cellule CD4+CD8+ Citometria a flusso (FC) Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
pl-PL Polish (Poland) Komórki.CD4-CD8-CD45R+TCR alfa beta+/100 komórek CD3:frakcja liczbowa:punkt w czasie:krew:ilościowy:cytometria przepływowa (FC)
Synonyms: CD4 CD8 Komórki CD4 Komórki CD4+CD8+ Komórki CD4-CD8- Komórki CD4-CD8-CD45R+TCR alfa beta+ Komórki CD4-CD8-CD45R+TCR alfa beta+ /100 komórek CD3
zh-CN Chinese (China) 细胞.CD4-CD8-CD45R+TCR alpha beta+/100 个细胞.CD3:计数型分数:时间点:全血:定量型:流式细胞测量术
Synonyms: B CD3细胞 CD4+CD8+细胞 CD4细胞 L3T4 Leu2 Leu-2 Leu3 Leu-3 Leu4;Leu-4;T3 T 细胞受体 A-B;T 细胞受体 alpha beta;T 细胞受体 α-β;TcR A-B;TcR α-β T4 T-4 T8 T-8 Tsuppressor W3/25 α β 动态 发现于 抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 抑制性 T 细胞 抑制性 T-细胞 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 细胞.CD4-CD8-CD45R+TCR αβ+;细胞.CD4-CD8-CD45R+T细胞受体αβ+;细胞.CD4-CD8-CD45R+T-细胞受体αβ+ 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液 诱导 T 细胞 诱导性 T 细胞 贝塔 辅助 T 细胞 辅助诱导 T 细胞 辅助诱导物 T 细胞 阿尔法

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88052-6