Version 2.78

Part Descriptions

LP263674-6   Cells.CD4-CD8-CD45R+TCR alpha beta+
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder that occurs when a mutation in the FAS gene prevents the normal death cycle of the lymphocytic white blood cells. The abnormal accumulation of non-malignant lymphocytes can lead to splenomegaly, lymphadenopathy, an increased risk of malignancy, and an autoimmune cytopenia resulting in anemia and thrombocytopenia. In ALPS there is an increase in the CD4- CD8- TCR alpha beta+ T cells, FAS ligand (FAS-L), and IL-10 protein. CD4-CD8- T cells are also known as double negative T cells (DNT). The expression of an atypical isoform of CD45 called CD45R (also known as B220) on CD4-CD8-TCR alpha beta+ T cells is sensitive and specific for ALPS. PMID: 19176318 PMID: 11513545 Source: Regenstrief LOINC

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD4-CD8-CD45R+TCR alpha beta+
Property
NCnc
Time
Pt
System
Bld
Scale
Qn
Method
Flow cytometry

Additional Names

Short Name
Cell.DNT-CD45R+TCRa b # Bld FC
Display Name
Cells.TCR alpha beta+DNT B220+ FC (Bld) [#/Vol]
Consumer Name Alpha Get Info
Cells.TCR Alpha Beta+DNT B220+, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.63
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
101414-1 Lymphocyte TCR alpha beta double negative subsets panel - Blood

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) células.CD4-CD8-CD45R+TCR alfa beta+:Concentración de número:Punto temporal:Sangre:Qn:Citometria de flujo (FC)
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Células CD4-CD8-CD45R + TCR alfa beta +:Concentración numérica:Punto temporal:Sangre:Cuantitativo:Citometría de flujo (FC)
fr-FR French (France) CD4-CD8-CD45RA+TCR alpha bêta+:Nombre/Volume:Ponctuel:Sang:Numérique:Cytométrie de flux
it-IT Italian (Italy) Cellule.CD4-CD8-CD45R+TCR alpha beta+:NCnc:Pt:Sangue:Qn:Citometria a flusso
Synonyms: Cellule CD4 Cellule CD4+CD8+ Citometria a flusso (FC) Concentrazione Numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
pl-PL Polish (Poland) Komórki.CD4-CD8-CD45R+TCR alfa beta+:stężenie liczbowe:punkt w czasie:krew:ilościowy:cytometria przepływowa (FC)
Synonyms: CD4 CD8 Komórki CD4 Komórki CD4+CD8+ Komórki CD4-CD8- Komórki CD4-CD8-CD45R+TCR alfa beta+ koncentracja
zh-CN Chinese (China) 细胞.CD4-CD8-CD45R+TCR alpha beta+:计数型浓度:时间点:全血:定量型:流式细胞测量术
Synonyms: B CD4+CD8+细胞 CD4细胞 L3T4 Leu2 Leu-2 Leu3 Leu-3 T 细胞受体 A-B;T 细胞受体 alpha beta;T 细胞受体 α-β;TcR A-B;TcR α-β T4 T-4 T8 T-8 Tsuppressor W3/25 α β 动态 单位体积内的数量或计数;数量型浓度(单位体积);数量或计数型浓度(计数/体积);数量或计数型浓度(单位体积);计数型浓度(单位体积) 发现于 抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 抑制性 T 细胞 抑制性 T-细胞 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 细胞.CD4-CD8-CD45R+TCR αβ+;细胞.CD4-CD8-CD45R+T细胞受体αβ+;细胞.CD4-CD8-CD45R+T-细胞受体αβ+ 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液 诱导 T 细胞 诱导性 T 细胞 贝塔 辅助 T 细胞 辅助诱导 T 细胞 辅助诱导物 T 细胞 阿尔法

Example Units

Unit Source
{cells}/uL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88053-4