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Part Descriptions

LP263640-7   Lipopolysaccharide binding protein
Lipopolysaccharide binding proteins (LBP) are encoded by the LBP gene [NCBI Gene ID:3929] and involved in the acute-phase immunologic response to gram negative bacterial infections. PMID: 8432532 LBP mediates the binding of lipopolysaccharides (LPS) to the CD14 receptor, triggering a pro-inflammatory response of macrophages, which is thought to be crucial for keeping infections under control. PMID: 10725789 Elevated LBP serum concentrations therefore is a potential marker for early diagnosis of an invasive bacterial infection. PMID: 17259880 Source: Regenstrief LOINC

LP263640-7   Lipopolysaccharide binding protein
Lipopolysaccharide binding protein (LBP) is an acute phase reactant that is constantly being produced by hepatocytes to maintain a plasma level of 5-15 ug/mL. When an acute phase response is initiated, interleukin-1 (IL-1) and interleukin-6 (IL-6) are released by monocytes and macrophages and together induce the synthesis of large amounts of LBP, raising its plasma concentration to 200 ug/mL. When gram-negative bacterial infection occurs, the innate immune system recognizes the glycolipid outer membrane of the bacteria called lipopolysaccharide (LPS). LBP strongly binds to LPS and transfers it to the cellular LPS receptor made up of CD14 and Toll-like receptor-4. http://www.bloodjournal.org/content/bloodjournal/98/13/3800.full.pdf?sso-checked=true The presence of LBP with low concentrations of LPS speeds up the release of cytokines earlier in the infection process. The main role of LBP is to initiate an inflammatory response even when the level of LPS is still low. Another way that LBP is important is that it catalyzes the movement of LPS to aggregates of high density lipoprotein particles which neutralize LPS.https://www.mesoscale.com/~/media/files/product%20inserts/human%20lbp.pdf Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Lipopolysaccharide binding protein:MCnc:Pt:Ser/Plas:Qn:IA
Long Common Name
Lipopolysaccharide binding protein [Mass/volume] in Serum or Plasma by Immunoassay
Short Name
LBP SerPl IA-mCnc
Display Name
Lipopolysaccharide binding protein IA [Mass/Vol]
Consumer Name Alpha Get Info
Lipopolysaccharide binding protein, Blood

Part Model Get Info

  • Component
    Lipopolysaccharide binding protein
    LP263640-7
    • Analyte
      Lipopolysaccharide binding protein
      LP263640-7
      • Component Numerator
        Lipopolysaccharide binding protein
        LP263640-7
        • Component Numerator Core
          Lipopolysaccharide binding protein
          LP263640-7
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    MCnc
    LP6827-2
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    IA
    LP217197-5

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.64 (MAJ)
Change Reason
Added Method of IA (immunoassay) based on the original term request and since this is currently the only method used to perform this test.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Lipopolysacharidy vázající protein:Hmotnostní koncentrace:Časový bod:Sérum/plazma:Kvantitativní:Imunoanalýza
de-ATGerman (Austria)Synonyms: Lipopolysaccharid binding Protein (LBP)
el-GRGreek (Greece)Δεσμευτική πρωτεΐνη λιποπολυσακχαριτών:MCnc:Pt:Ορός/Πλάσμα:Qn:IA
Synonyms: CHEM IA MCnc Pt Qn Δεσμευτική πρωτεΐνη λιποπολυσακχαριτών Ορός Ορός/Πλάσμα Πλάσμα Πρωτεΐνη
es-ESSpanish (Spain)Proteína de unión a lipopolisacárido:Concentración de masa:Punto temporal:Suero o Plasma:Qn:IA
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Proteína de unión a lipopolisacáridos:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
fr-FRFrench (France)Lipopolysaccharide binding protein:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
it-ITItalian (Italy)Lipopolisaccaride, proteina legante:MCnc:Pt:Siero/Plasma:Qn:IA
Synonyms: Chimica Concentrazione di Massa Immunoassay Plasma Proteina legante il lipopolisaccaride Punto nel tempo (episodio) Siero Siero o Plasma
pl-PLPolish (Poland)Białko wiążące lipopolisacharydy:stężenie masowe:punkt w czasie:surowica lub osocze:ilościowy:metoda immunologiczna
zh-CNChinese (China)脂多糖结合蛋白:质量浓度:时间点:血清/血浆:定量型:免疫测定法
Synonyms: LBP;内毒素结合蛋白 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 结合性 结合性的 血清或血浆

Example Units

UnitSource
ug/mLExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88054-2