Version 2.80

Part Descriptions

LP32397-9   Ab.IgG4
IgG4 is the least common subtype of IgG, and it has a variety of functions. In the context of allergic disease it is thought to have an immune-inhibitory role in preventing anaphylaxis and is commonly known as a "blocking" antibody. IgG4 binding to an allergen can compete with IgE-mediated binding, thereby inhibiting the activation of mast cells and basophils and IgE-mediated presentation to T-cells. Measuring IgG4 and its ratio to IgE has a role in monitoring allergen specific immunotherapy PMID: 26023323. IgG4 is also thought to have a role in autoimmunity and be involved in a less defined entity known as IgG4-Related Disease, a chronic immune-mediated fibroinflammatory disorder that often manifests with tumor-like masses .[https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/igg4-related-disease/igg4-related-disease] Source: Regenstrief LOINC

LP35808-2   Wuchereria bancrofti+Brugia malayi
Wuchereria bancrofti, Brugia malayi and Brugia timori are the three species of filaria that cause lymphatic filariasis in humans living in the tropics and sub-tropics. Infection is spread from person to person by mosquito bites. The adult worms live and reproduce in the human lymphatic system, creating millions of microscopic worms called microfilariae. When a person who is infected is bitten by a mosquito, the mosquito becomes infected, and the microfilariae mature inside the mosquito. When the mosquito bites another person, the larval worms are passed from the mosquito to the human and travel to the lymphatic system, where they grow into adult worms. Most people with lymphatic filariasis are asymptomatic, and a few develop lymphedema, primarily in the legs, but also in the arms, breasts, and genitals. People with lymphedema are more susceptible to bacterial infections of the skin and lymphatic system, which can lead to hardening and thickening of the skin, also known as elephantiasis.
Filarial infection can also cause tropical pulmonary eosinophilia syndrome. Lymphatic filariasis primarily develops in people who have gotten mosquito bites in an endemic area over an extended period of time. [https://www.cdc.gov/parasites/lymphaticfilariasis/] Studies have shown that different IgG isotypes may characterize different stages of infection. IgG1, IgG2 and IgG3 are most common in asymptomatic patients, while IgG4 is a marker of active infection. PMID: 28118850 In addition, larval antigens may have a stronger IgG1 response, followed by IgG2 and IgG3, while IgG4 is the most common isotype found in response to adult filaria. PMID: 9491413 Source: Regenstrief LOINC

Fully-Specified Name

Component
Wuchereria bancrofti+Brugia malayi Ab.IgG4
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
IA

Additional Names

Long Common Name
Wuchereria bancrofti+Brugia malayi IgG4 Ab [Presence] in Serum by Immunoassay
Short Name
W bancr+B malayi IgG4 Ser Ql IA
Display Name
W. bancrofti+Brugia malayi IgG4 IA Ql (S)
Consumer Name Alpha Get Info
Wuchereria bancrofti+Brugia malayi IgG4 antibody, Blood

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.63 (ADD)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Νηματώδη Wuchereria bancrofti+Brugia malayi Ab.IgG4:PrThr:Pt:Ορός:Ord:IA
Synonyms: Brugia malayi (Φιλάρια της Μαλαισίας) PrThr Wuchereria bancrofti (Βουχερέρια η μπανκρόφτειος) Νηματώδη Wuchereria bancrofti+Brugia malayi
es-ES Spanish (Spain) Wuchereria bancrofti+Brugia malayi IgG4:PrThr:Punto temporal:Suero:Ord:IA
es-MX Spanish (Mexico) Wuchereria bancrofti + Brugia malayi Ab.IgG4:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
et-EE Estonian (Estonia) Wuchereria bancrofti + Brugia malayi antikehad.IgG4:PrThr:Pt:S:Ord:IA
Synonyms: Järgarvuline Juhuslik Seerum
fr-CA French (Canada) Wuchereria bancrofti+Brugia malayi, IgG4:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FR French (France) Wuchereria bancrofti + Brugia malayi Ac IgG4:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
fr-BE French (Belgium) Wuchereria bancrofti + Brugia malayi Anticorps. IgG4:PrThr:Temps ponctuel:Sérum:Ordinal:IA
Synonyms: Anticorps
it-IT Italian (Italy) Wuchereria bancrofti + Brugia malayi Ab.IgG4:PrThr:Pt:Siero:Ord:IA
Synonyms: Anticorpi IgG4 anticorpo Immunoassay Microbiologia Presenza o Soglia Punto nel tempo (episodio) Siero Wuchereria bancrofti+Brugia malayi
nl-NL Dutch (Netherlands) Wuchereria bancrofti + Brugia malayi As.IgG4:aanwezigheid:moment:serum:ordinaal:immunoassay
Synonyms: antistof; antilichaam IA
ru-RU Russian (Russian Federation) Wuchereria bancrofti + Brugia malayi Ат.IgG4:PrThr:ТчкВрм:Сыв:Пор:IA
Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) Wuchereria bancrofti + Brugia malayi Ab.IgG4:MevcEşik:Zmlı:Ser:Srl:İA
Synonyms: İmmünölçüm, immünoassay Mevcut
zh-CN Chinese (China) 班氏吴策线虫+马来布鲁线虫 抗体.IgG4:存在情况或阈值:时间点:血清:序数型:免疫测定法
Synonyms: Ab.IgG4;IgG4;抗体 IgG4 Ab;自身抗体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 时刻;随机;随意;瞬间 班氏丝虫 班氏丝虫+马来丝虫 马来丝虫 Ab 马来丝虫;马来丝虫病;马来布鲁线虫病 马来丝虫抗体 马来布鲁线虫 Ab

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88179-7