88542-6

HIV 1 RNA integrase gene mutations detected [Identifier] in Cerebrospinal Fluid by Sequencing

Active

Term Description

Used to determine HIV 1 RNA resistance in CSF samples from patients with neurological symptoms of HIV who may have CSF/plasma discordance in the amount of circulating virus as well as resistance patterns. PMID: 25344810

Part Description

LP150045-5 Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977. PMID: 271968 Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost. PMID: 18576944 Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template. PMID: 20858600 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: HIV 1 RNA integrase gene mutations detected:Prid:Pt:CSF:Nom:Sequencing
Long Common Name: HIV 1 RNA integrase gene mutations detected [Identifier] in Cerebrospinal Fluid by Sequencing
Short Name: HIV 1 RNA IN Mut Det CSF Seq
Display Name: HIV 1 RNA IN mutations detected Sequencing Nom (CSF)
Consumer Name Alpha Get Info: HIV 1 RNA IN variant analysis, Spinal fluid

Part Model Get Info

Component
HIV 1 RNA integrase gene mutations detected
LP265778-3
- Analyte
  HIV 1 RNA integrase gene mutations detected
  LP265778-3
  - Component Numerator
    HIV 1 RNA integrase gene mutations detected
    LP265778-3
    - Component Numerator Core
      HIV 1 RNA integrase gene
      LP265777-5
    - Component Numerator Core Suffix
      mutations detected
      LP32420-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Prid
LP6850-4
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
CSF
LP7156-5
- System Core
  CSF
  LP7156-5
- Super System
  NULL
Scale
Nom
LP7750-5
Method
Sequencing
LP150045-5

Example Answer List: LL3697-1

Source: Laboratory Corporation of America

Answer	Code	Score	Answer ID
V31I HIV mutation in the integrase (IN) coding region			LA19757-6
V72I HIV mutation in the integrase (IN) coding region			LA24443-6
T97A HIV mutation in the integrase (IN) coding region			LA24440-2
L101I HIV mutation in the integrase (IN) coding region			LA24444-4
V113I HIV mutation in the integrase (IN) coding region			LA24445-1
S119S/T HIV mutation in the integrase (IN) coding region			LA24442-8
T124A HIV mutation in the integrase (IN) coding region			LA24446-9
E138D HIV mutation in the integrase (IN) coding region			LA24447-7
Y143R HIV mutation in the integrase (IN) coding region			LA24441-0
E157E/Q HIV mutation in the integrase (IN) coding region			LA24449-3
K188R HIV mutation in the integrase (IN) coding region			LA24450-1
G193E HIV mutation in the integrase (IN) coding region			LA24451-9
V201I HIV mutation in the integrase (IN) coding region			LA24452-7
V234L HIV mutation in the integrase (IN) coding region			LA24453-5
D288N HIV mutation in the integrase (IN) coding region			LA24454-3

Basic Attributes

Class: ABXBACT
Type: Laboratory
First Released: Version 2.64
Last Updated: Version 2.83 (MIN)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	HIV 1 RNA integráza genové mutace detekované:Přítomnost nebo identita:Časový bod:Mozkomíšní mok:Nominální:Sekvenace
el-GR	Greek (Greece)	Γονίδιο ιντεγκράσης RNA του ιού της ανθρώπινης ανοσοανεπάρκειας 1 ανιχνευθείσες μεταλλάξεις:Prid:Pt:ΕΝΥ:Nom:Αλληλούχιση Synonyms: ABXBACT HIV 1 Nom Prid Pt RNA RNA ιού της ανθρώπινης ανοσοανεπάρκειας 1 Αλληλούχιση ανιχνευθείσες μεταλλάξεις Γονίδιο Γονίδιο ιντεγκράσης RNA του ιού της ανθρώπινης ανοσοανεπάρκειας 1 ΕΝΥ Ιός ανθρώπινης ανοσοανεπάρκειας Μεταλλάξεις
es-ES	Spanish (Spain)	Gen integrasa VIH1 RNA Detección de mutaciones:Presencia o identidad:Punto temporal:Líquido Cefalorraquideo:Nom:Secuenciación
es-MX	Spanish (Mexico)	Se detectaron mutaciones en el gen de la integrasa del ARN del VIH 1:Presencia o identidad:Punto temporal:Fluído espinal cerebral:Nominal:Secuenciación
fr-FR	French (France)	VIH-1 ARN gène de l'intégrase mutations détectées:Identification:Ponctuel:Liquide céphalorachidien:Résultat nominal:Séquençage
it-IT	Italian (Italy)	HIV 1, RNA gene integrasi, mutazioni identificate:Prid:Pt:LCS:Nom:Sequenziamento Synonyms: Liquido cerebrospinale Presenza o Identità Punto nel tempo (episodio) RNA dell''HIV 1 Suscettibilità agli antibiotici
pl-PL	Polish (Poland)	Integraza HIV 1 RNA gen wykryte mutacje:obecność lub identyfikacja:punkt w czasie:płyn mózgowo-rdzeniowy:skala nominalna:sekwencjonowanie Synonyms: Gen integrazy RNA ludzkiego wirusa niedoboru odporności typu 1;Gen RNA integrazy HIV 1 Ludzki wirus niedoboru odporności Ludzki wirus niedoboru odporności typu 1 RNA ludzkiego wirusa niedoboru odporności typu 1 wynik kategorialny
zh-CN	Chinese (China)	HIV 1 型 RNA 整合酶基因已检出的突变:存在与否或特征标识:时间点:脑脊液:名义型:序列测定 Synonyms: Ⅰ AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） RNA 整合酶（IN）基因 HIV1 RNA HIV1;HTLV 3;HTLV III;人类免疫缺陷病毒 1 型;人类免疫缺陷病毒 I 型;HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） I 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答存在;存在与否;特征标识;身份;身份标识已发现的突变序列分析;测序抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类时刻;随机;随意;瞬间核糖核酸;Ribonucleic acid 突变突变类;基因突变脊液脊髓液脑脊液（Cerebral spinal fluid，CSF）脑脊髓液遗传基因;遗传因子;吉恩;生物基因

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Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.