Version 2.78

Part Description

LP14255-1   Cytomegalovirus
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html] Source: Regenstrief LOINC

Fully-Specified Name

Component
Cytomegalovirus DNA
Property
PrThr
Time
Pt
System
Respiratory system specimen.lower
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
CMV DNA Lower resp Ql NAA+probe
Display Name
CMV DNA NAA+probe Ql (Lower resp)
Consumer Name Alpha Get Info
Cytomegalovirus (CMV), Lower respiratory

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.77
Change Reason
Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC;
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
94393-6 Respiratory pathogens DNA and RNA panel - Lower respiratory specimen by NAA with probe detection

Member of these Groups Get Info

LOINC Group Group Name
LG34031-1 Cytomegalovirus DNA|PrThr|Sys:ANYResp

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Cytomegalie-Virus DNA:Nachweis oder Schwellenwert:Zeitpunkt:Respirationstrakt.unterer:Ordinal:Zielfragmentamplifikation mit Sondendetektion
Synonyms: CMV
es-MX Spanish (Mexico) ADN de citomegalovirus:Presencia o umbral:Punto temporal:Muestra de vías respiratorias inferiores:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ES Spanish (Spain) Citomegalovirus ADN:PrThr:Punto temporal:Muestra de vías respiratorias inferiores:Ord:Sonda con amplificación dirigida
Synonyms: Muestra del tracto respiratorio Muestra respiratoria Tracto respiratorio
fr-FR French (France) Cytomégalovirus ADN:Présence/Seuil:Ponctuel:Voies respiratoires inférieures:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Citomegalovirus DNA:PrThr:Pt:Campione da Sistema Respiratorio.inferiore:Ord:Sonda.amp.tar
Synonyms: Campione da Apparato Respiratorio Campione da apparato respiratorio inferiore Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL Dutch (Netherlands) Cytomegalovirus DNA:aanwezigheid:moment:onderste luchtwegen:ordinaal:probe-detectie
Synonyms: onderste ademhalingsstelsel; systema respiratorium inferior probe.amp.tar systema respiratorium; ademhalingsstelsel

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=88558-2