88622-6
Cytomegalovirus [Presence] in Ocular fluid by Shell vial culture
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Part Descriptions
LP14255-1 Cytomegalovirus
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html]
Source: Regenstrief LOINC
LP36602-8 Shell vial culture
Virus culture is often more sensitive than trying to detect viruses directly in clinical samples. Shell vial culture is a modification of the conventional cell culture technique for rapid detection of viruses in vitro. The technique involves inoculation of the clinical specimen on to cell monolayer grown on a cover slip in a shell vial culture tube, followed by low speed centrifugation and incubation. This system works on the principle that the low speed centrifugation enhances viral infectivity to the susceptible cells. It is thought that the minor trauma to the cell surface produced as a result of low speed centrifugation mechanical force enhances the viral entry in to the cells, which in turn reduces the total time taken for the virus to produce infection of cells. Virus may be detected by direct fluorescent antibody (DFA) or indirect fluorescent antibody (IFA) staining within hours or days of inoculation.
Source: Regenstrief LOINC
LP7448-6 Ocular fld
The "Ocular fld" System in LOINC encompasses aqueous humor and vitreous humor. Aqueous humor is found in the anterior and posterior chambers of the eye, both of which are located anterior to the lens. Vitreous humor is found in the vitreous chamber, which is located between the lens and the retina. This System is used for LOINC terms that represent tests run on either aqueous or vitreous fluid; it does not imply that both types of fluid are tested in any given instance.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Cytomegalovirus
- Property
- PrThr
- Time
- Pt
- System
- Ocular fld
- Scale
- Ord
- Method
- Shell vial culture
Additional Names
- Short Name
- CMV Ocflu Ql Shell Vial Cult
- Display Name
- CMV Shell vial culture Ql (Ocular fluid)
- Consumer Name Alpha Get Info
- Cytomegalovirus (CMV) culture, Eye fluid
Example Answer List: LL744-4
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Detected | LA11882-0 | ||
| Not detected | LA11883-8 |
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.64
- Order vs. Observation
- Both
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG50929-5 | Cytomegalovirus| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Cytomegalie-Virus: Synonyms: CMV; |
| es-ES | Spanish (Spain) | Citomegalovirus: |
| es-MX | Spanish (Mexico) | Citomegalovirus: |
| fr-CA | French (Canada) | Cytomégalovirus: |
| fr-BE | French (Belgium) | Cytomégalovirus: Synonyms: CMV |
| fr-FR | French (France) | Cytomégalovirus: |
| it-IT | Italian (Italy) | Citomegalovirus: Synonyms: Coltura Shell vial Liquido oculare Microbiologia Presenza o Soglia Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | Cytomegalovirus: |
| pl-PL | Polish (Poland) | Wirus cytomegalii: Synonyms: Cytomegalowirus |
| zh-CN | Chinese (China) | 巨细胞病毒: Synonyms: CMV; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=88622-6
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