Version 2.80

Term Description

The qualitative detection of known EML4-ALK gene fusions by various molecular genetic techniques to determine therapeutic treatment for non-small cell lung cancer (NSCLC).

Part Description

LP200476-2   inv(2)(p21;p23)(EML4,ALK)
The inversion on chromosome 2 resulting in the fusion of genes EM4L [HGNC ID: 1316] and ALK [HGNC Gene ID: 427] is a chromosomal abnormality found in various histologic types of non-small-cell lung cancer (NSCLC). The fusion encodes for the EML4-ALK protein, which promotes and maintains cancer cell growth. The detection of EML4-ALK may be useful for predicting the potential response to ALK inhibitors as a therapeutic option for patients with lung cancer. PMID: 19170230 Source: Regenstrief LOINC

Fully-Specified Name

Component
inv(2)(p21;p23)(EML4,ALK) fusion transcript
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Molgen

Additional Names

Long Common Name
inv(2)(p21;p23)(EML4,ALK) fusion transcript [Presence] in Tissue by Molecular genetics method
Short Name
inv(2)(EML4,ALK) Tiss Ql
Display Name
inv(2)(p21;p23)(EML4,ALK) fusion transcript Molgen Ql (Tiss)
Consumer Name Alpha Get Info
inv(2)(p21;p23)(EML4,ALK) fusion transcript analysis, Tissue

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.72 (MIN)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) inv(2)(p21;p23)(EML4,ALK) μεταγραφή συγχώνευσης:PrThr:Pt:Ιστός:Ord:Μοριακή γενετική
Synonyms: inv(2)(p21;p23)(EML4,ALK) PrThr
es-ES Spanish (Spain) inv(2)(p21;p23)(EML4,ALK) Tránscritos de fusión:PrThr:Punto temporal:Tejido:Ord:Genética molecular
es-MX Spanish (Mexico) transcrito de fusión inv (2) (p21; p23) (EML4, ALK):Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Genética molecular
fr-FR French (France) inv(2)(p21;p23)(EML4,ALK) transcrit de fusion:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Biologie moléculaire
fr-CA French (Canada) inv(2)(p21;p23)(EML4,ALK) transcrit de fusion:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Molgen
it-IT Italian (Italy) inv(2)(p21;p23)(EML4,ALK), trascritto di fusione:PrThr:Pt:Tessuto:Ord:Molgen
Synonyms: Genetica molecolare Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
nl-NL Dutch (Netherlands) inv(2)(p21;p23)(EML4,ALK) fusietranscript:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:moleculair genetisch onderzoek
Synonyms: molgen
tr-TR Turkish (Turkey) inv(2)(p21;p23)(EML4,ALK) füzyon transkript:MevcEşik:Zmlı:Doku:Srl:Molgen
Synonyms: Mevcut
zh-CN Chinese (China) inv(2)(p21;p23)(EML4,ALK) 融合转录物:存在情况或阈值:时间点:组织与涂片:序数型:分子遗传学类实验室方法
Synonyms: Ⅱ II 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 倒位(2)(p21;p23)(EML4,ALK);基因倒位;基因倒置;倒位;倒置;gene inversion 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录 间变型淋巴瘤激酶 间变性淋巴瘤激酶（anaplastic lymphoma kinase，ALK）

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CodeSystem lookup
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