Version 2.80

Term Description

This term detects mutations in the 23S rRNA gene responsible for bacterial resistance to azithromycin.

Part Description

LP266750-1   Bacterial 23S rRNA gene azithromycin resistance mutation
Bacterial resistance to macrolide drugs has increased in conjunction with their heavy use in both medicine and animal husbandry. While there are a number of mechanisms bacteria use to resist the efficacy of drug treatment, the one used by macrolides is to bind to the large 50S subunit of the bacterial ribosome and interfere with protein synthesis. Changes of specific nucleotides in the 23S rRNA inside the large ribosomal unit are the root cause of many instances of bacterial resistance to macrolides. PMID: 11120937 Source: Regenstrief LOINC

Fully-Specified Name

Component
Bacterial 23S rRNA gene azithromycin resistance mutation
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Long Common Name
Bacterial 23S rRNA gene azithromycin resistance mutation [Presence] by Molecular method
Short Name
Bact 23S rRNA azith res mut Islt/Spm Ql
Display Name
Bacterial 23S rRNA gene azithromycin resistance mutation Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Bacterial 23S rRNA gene azithromycin resistance mutation

Preferred Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.65 (MAJ)
Change Reason
Updated System from "Isolate" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Bakterielles 23S rRNA-Gen Azithromycin-Resistenzmutation:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
el-GR Greek (Greece) Μετάλλαξη βακτηριακής ανθεκτικότητας του γονιδίου 23S rRNA της αζιθρομυκίνης:PrThr:Pt:Απομονωθέν στέλεχος/Δείγμα:Ord:Μοριακή γενετική
Synonyms: PrThr Αζιθρομυκίνη Γονίδιο Μετάλλαξη βακτηριακής ανθεκτικότητας του γονιδίου 23S rRNA της αζιθρομυκίνης
es-ES Spanish (Spain) Mutación del Gen 23S rRNA de resistencia a azitromicina:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX Spanish (Mexico) Mutación de resistencia a la azitromicina del gen del rRNA 23S bacteriano:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-FR French (France) Mutation gène bactérien ARNr 23S résistant à l'azithromycine:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) Gene batterico 23S rRNA, mutazione resistenza a azitromicina:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Genetica molecolare Isolato o Campione Mutazione di resistenza a azitromicina di gene batterico 23S rRNA Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) bacteriële azitromycineresistentie 23S-rRNA-genmutatie:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
zh-CN Chinese (China) 细菌 23S rRNA 基因阿奇霉素耐药性突变:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 受检物 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 核蛋白体 RNA 核蛋白体 RNA（Ribosomal RNA，RRNA） 核蛋白体核糖核酸 核醣体 RNA 电阻 细菌 23S rRNA 基因阿奇霉素耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变 细菌性 细菌的 耐性 试样 遗传基因;遗传因子;吉恩;生物基因 阻力 阿奇霉素;叠氮红霉素;西舒美;阿希红霉素;希舒美

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