Version 2.80

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.

Part Description

LP16719-4   Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC , PMID: 23573256

Fully-Specified Name

Component
Jo-1 extractable nuclear Ab
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
Line blot

Additional Names

Long Common Name
Jo-1 extractable nuclear Ab [Presence] in Cerebral spinal fluid by Line blot
Short Name
ENA Jo1 Ab CSF Ql Line blot
Display Name
Jo-1 extractable nuclear Ab Line blot Ql (CSF)
Consumer Name Alpha Get Info
Jo-1 extractable nuclear antibody, Spinal fluid

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64 (ADD)
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG20855-9 Jo-1 extractable nuclear Ab|PrThr|Pt|CSF

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) εκχυλίσιμα πυρηνικά αντιγόνα Jo-1 Αντίσωμα:PrThr:Pt:ΕΝΥ:Ord:Γραμμή κηλίδωσης
Synonyms: PrThr Εκχυλίσιμα πυρηνικά εκχυλίσιμα πυρηνικά αντιγόνα Jo-1 Πυρηνικό
es-ES Spanish (Spain) Jo-1 Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Line blot
es-MX Spanish (Mexico) Ab nuclear extraíble Jo-1:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Mancha de línea
fr-FR French (France) Jo-1 anticorps:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Blot en ligne
fr-CA French (Canada) Jo-1 nucléaire soluble, Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoessai sur bandelette
it-IT Italian (Italy) Jo-1, nucleare estraibile Ab:PrThr:Pt:LCS:Ord:Line blot
Synonyms: anticorpo ENA Jo1 Liquido cerebrospinale Presenza o Soglia Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) jo-1 extraheerbaar nucleair As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:lijnblot
Synonyms: antistof; antilichaam
pl-PL Polish (Poland) Jo-1 rozpuszczalny jądrowy Ab:granica wykrywalności:punkt w czasie:płyn mózgowo-rdzeniowy:półilościowy:line blot
Synonyms: Jo-1 rozpuszczalny jądrowy Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała do rozpuszczalnego jądrowego antygenu Jo-1 Przeciwciała przeciwjądrowe
zh-CN Chinese (China) Jo-1 可提取性核 抗体:存在情况或阈值:时间点:脑脊液:序数型:线点印迹法
Synonyms: Ⅰ Ab;自身抗体 ANA CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 ENA Ab ENA Jo1 Ab ENA Jo-1 Ab ENA Jo1 抗体 ENA Jo-1 抗体 ENA Jo1;ENA Jo-1;Jo-1 可提取性核 Ag;Jo-1 可提取性核抗原;可提取性核 Ag Jo1;可提取性核 Ag Jo-1;可提取性核抗原 Jo1;可提取性核抗原 Jo-1;组氨酰-tRNA 合成酶;组氨酰基-tRNA 合成酶 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 I Jo1 可提取性核 Ab Jo-1 可提取性核 Ab Jo1 可提取性核 Ag Ab Jo-1 可提取性核 Ag Ab Jo1 可提取性核抗体 Jo1 可提取性核抗原 抗体 Jo-1 可提取性核抗原 抗体 NA 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 可提取性核 Ab 可提取性核 Ag Jo1 Ab 可提取性核 Ag Jo-1 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 Jo1 抗体 可提取性核抗原 Jo-1 抗体 可提取性核抗原之抗体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗 ENA 抗可提取性核 Ag 抗可提取性核抗原 抗核 Ab 抗核抗体 抗核抗体（Antinuclear antibody，ANA） 时刻;随机;随意;瞬间 核;胞核 线点杂交技术;线点杂交法;线条状印迹法 细胞核 Ab 胞核 Ab 胞核抗体 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89529-2