LOINC
Version 2.72

89529-2Jo-1 extractable nuclear Ab [Presence] in Cerebral spinal fluid by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Source: Regenstrief LOINC

Part Description

LP16719-4   Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books:NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. [PMID:23573256] Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. [PMID:17392287] Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component
Jo-1 extractable nuclear Ab
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
Line blot

Additional Names

Short Name
ENA Jo1 Ab CSF Ql Line blot
Display Name
Jo-1 extractable nuclear Ab Line blot Ql (CSF)
Consumer Name Alpha
Jo-1 extractable nuclear antibody, Spinal fluid

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation
Both

Member of these Groups

LG20855-9 Jo-1 extractable nuclear Ab|PrThr|Pt|CSF

Language Variants Get Info

zh-CNChinese (China)
Jo-1 可提取性核 抗体:存在情况或阈值:时间点:脑脊液:序数型:线点印迹法
nl-NLDutch (Netherlands)
jo-1 extraheerbaar nucleair As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:lijnblot
fr-CAFrench (Canada)
Jo-1 nucléaire soluble , Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoessai sur bandelette
fr-FRFrench (France)
Jo-1 anticorps:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Blot en ligne
it-ITItalian (Italy)
Jo-1, nucleare estraibile Ab:PrThr:Pt:LCS:Ord:Line blot
es-MXSpanish (Mexico)
Ab nuclear extraíble Jo-1:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Mancha de línea
es-ESSpanish (Spain)
Jo-1 Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89529-2