Version 2.78

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Source: Regenstrief LOINC

Part Description

LP16714-5   Histone
Histones are small nuclear proteins that together with dsDNA, represent a nucleosome, the structural unit of chromatin. Anti-histone antibodies are associated with various autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren's syndrome, systemic sclerosis, infectious diseases (including HIV), and some neurological disorders such as Alzheimer's disease and dementia. Nearly all patients with drug-induced SLE have anti-histone antibodies, but they are also present in patients with idiopathic forms of the disease. One study showed a correlation between SLE with positive anti-dsDNA, anti-nucleosome and anti-histone antibodies and renal disease, including proliferative glomerulonephritis. PMID: 24649358 Source: Regenstrief LOINC, PMID: 24649358

Fully-Specified Name

Component
Histone Ab
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
Line blot

Additional Names

Short Name
Histone Ab CSF Ql Line blot
Display Name
Histone Ab Line blot Ql (CSF)
Consumer Name Alpha Get Info
Histone antibody, Spinal fluid

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.64
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG26116-0 Histone Ab|PrThr|Pt|CSF

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Histona Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Line blot
es-MX Spanish (Mexico) Histona Ab:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Mancha de línea
fr-FR French (France) Histones anticorps:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Blot en ligne
fr-CA French (Canada) Histone, Ac:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Immunoessai sur bandelette
it-IT Italian (Italy) Istone Ab:PrThr:Pt:LCS:Ord:Line blot
Synonyms: anticorpo Liquido cerebrospinale Presenza o Soglia Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) histon As:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:lijnblot
Synonyms: antistof; antilichaam
zh-CN Chinese (China) 组蛋白 抗体:存在情况或阈值:时间点:脑脊液:序数型:线点印迹法
Synonyms: Ab;自身抗体 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 线点杂交技术;线点杂交法;线条状印迹法 组朊 组朊 Ab 组朊抗体 组蛋白 Ab 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=89530-0