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Part Description

LP267947-2   Suppression of tumorigenicity 2.soluble
Suppression of tumorigenicity 2 (ST2) is a member of the interleukin 1 receptor family. It was discovered in 1989, but in 2002 it was realized that ST2 was excreted by cardiac fibroblasts and cardiomyocytes in response to stress. ST2 has two isoforms which are the transmembrane form (ST2L) and the soluble form (sST2). They both bind to the ligand Interleukin-33 (IL-33). When IL-33 binds to ST2L, the complex provides cardiac protection by reducing myocardial fibrosis, cardiomyocyte hypertrophy, apoptosis, and improving myocardial function. When cardiac injury occurs, the IL-33/ST2 system is upregulated in cardiomyocytes and fibroblasts. sST2 becomes strongly attracted to IL-33, competing with ST2L for binding sites. The IL-33/sST2 system counteracts the cardiac protection provided by the IL-33/ST2L system. sST2 concentrations are believed to be associated with cardiovascular stress and fibrosis. As a biomarker, sST2 is a strong predictor of both chronic and acute heart failure outcomes. sST2 does not appear to be significantly affected by age, gender, body mass index, and renal function. PMID: 26761075 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Suppression of tumorigenicity 2.soluble:MCnc:Pt:Ser:Qn:IA
Long Common Name
ST2.soluble [Mass/volume] in Serum by Immunoassay
Short Name
ST2.soluble Ser IA-mCnc
Display Name
ST2.soluble IA (S) [Mass/Vol]
Consumer Name Alpha Get Info
ST2.soluble, Blood

Part Model Get Info

  • Component
    Suppression of tumorigenicity 2.soluble
    LP267947-2
    • Analyte
      Suppression of tumorigenicity 2.soluble
      LP267947-2
      • Component Numerator
        Suppression of tumorigenicity 2.soluble
        LP267947-2
        • Component Numerator Core
          Suppression of tumorigenicity 2.soluble
          LP267947-2
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    MCnc
    LP6827-2
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    IA
    LP217197-5

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.65
Last Updated
Version 2.65 (ADD)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)ST2.rozpustný:Hmotnostní koncentrace:Časový bod:Sérum:Kvantitativní:Imunoanalýza
el-GRGreek (Greece)Καταστολή της ογκογένεσης 2.διαλυτό:MCnc:Pt:Ορός:Qn:IA
Synonyms: CHEM IA MCnc Pt Qn Καταστολή της ογκογένεσης 2.διαλυτό Ορός
es-ESSpanish (Spain)Supresión de la tumorigenicidad soluble 2:Concentración de masa:Punto temporal:Suero:Qn:IA
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Supresión de tumorigenicidad 2.soluble:Concentración de masa:Punto temporal:Suero:Cuantitativo:Inmunoensayo
fr-FRFrench (France)ST2 soluble anticorps:Masse/Volume:Ponctuel:Sérum:Numérique:Immunoanalyse
it-ITItalian (Italy)Soppressione della tumorigenicità-2.solubile:MCnc:Pt:Siero:Qn:IA
Synonyms: Chimica Concentrazione di Massa Immunoassay Punto nel tempo (episodio) Siero Soppressione solubile della tumorigenicità-2
pl-PLPolish (Poland)ST2.rozpuszczalny:stężenie masowe:punkt w czasie:surowica:ilościowy:metoda immunologiczna
zh-CNChinese (China)致瘤性抑制因子 2.可溶性:质量浓度:时间点:血清:定量型:免疫测定法
Synonyms: Ⅱ II 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 致瘤性（致瘤、致癌性、致癌）抑制因子（抑制素） 2.可溶性;可溶性致癌抑制因子 2;可溶性 ST2;可溶性肿瘤因子 2 抑制剂;可溶性致瘤性抑制因子 2;可溶性肿瘤抑制素 2;soluble suppression of tumorigenicity 2;sST2

Example Units

UnitSource
ng/mLExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=90239-5