Version 2.78

Part Descriptions

LP268100-7   Natural killer cell cytotoxicity.IL-2 stimulated 1.88:1 effector to target cell ratio
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays. Source: Regenstrief LOINC

LP264987-1   Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays. Source: Regenstrief LOINC

Fully-Specified Name

Component
Natural killer cell cytotoxicity.IL-2 stimulated 1.88:1 effector to target cell ratio/Positive control
Property
RelACnc
Time
Pt
System
Bld MC
Scale
Qn
Method

Additional Names

Short Name
NK cyto IL2 1.88:1 E:T/Pos cntrl Bld MC
Display Name
NK cytotoxicity.IL-stim 1.88:1 E:T ratio/Positive control (Bld MC) [Rel units/Vol]
Consumer Name Alpha Get Info
NK Cytotoxicity.IL-stim 1.88:1 E:T Ratio/Positive Control, Blood

Basic Attributes

Class
HEM/BC
Type
Laboratory
First Released
Version 2.65
Last Updated
Version 2.65
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
98030-0 Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC)

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Citotoxicidad de las células Natural killer estimuladas con IL-2. Proporción efector con célula diana 1.88: 1/Control positivo:Concentración arbitraria relativa:Punto temporal:Celulas Mononucleares sanguíneas:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Citotoxicidad de células asesinas naturales. Relación efectora / célula diana estimulada por IL-2 1,88:1 / Control positivo:Concentración relativa arbitraria:Punto temporal:Células mononucleares de sangre:Cuantitativo
fr-FR French (France) Cytotoxicité cellules NK stimulées par IL-2 Patient 1.88/1 %:Activité arbitraire relative:Ponctuel:Cellules mononucléées de sang périphérique:Numérique:
it-IT Italian (Italy) Cellula natural killer, citotossicità. rapporto IL-2 stimolato 1.88:1 effettore verso cellula target/Controllo positivo:RelACnc:Pt:Cellule mononucleate da sangue intero:Qn:
Synonyms: Cellula natural killer, citotossicità. rapporto IL stimolato 1.88:1 effettore verso cellula target Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue
zh-CN Chinese (China) 自然杀伤细胞细胞毒性.IL-2 刺激型 效应细胞/靶细胞比 1.88:1/阳性对照:相对任意型浓度:时间点:全血单个核细胞:定量型:
Synonyms: Ⅰ Ⅱ I II 全血（血液、血）单个核细胞（单核细胞、MC）;全血标本（样品、样本、试样）单个核细胞 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 相对任意浓度;相对型任意浓度;相对人工型浓度 结果阳性 自然杀伤细胞（NK细胞）细胞毒性.IL-2（白细胞介素 2、白介素 2） 刺激型（刺激法） 效应细胞/靶细胞比（比率、比值） 1.88:1 血;血液 血液学/细胞计数;血液学与细胞计数 试验阳性 试验阳性的 阳性对照（对照品、对照样品、对照样本、对照试样、对照标本、对照标准、参照、参照品） 阳性结果

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=90243-7