90245-2
Natural killer cell cytotoxicity.IL-stimulated 3.75:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Active
Part Descriptions
LP268099-1 Natural killer cell cytotoxicity.IL-2 stimulated 3.75:1 effector to target cell ratio
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.IL-2 stimulated 3.75:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Additional Names
- Short Name
- NK cyto IL2 3.75:1 E:T/Pos cntrl Bld MC
- Display Name
- NK cytotoxicity.IL-stim 3.75:1 E:T ratio/Positive control (Bld MC) [Rel units/Vol]
- Consumer Name Alpha Get Info
- NK Cytotoxicity.IL-stim 3.75:1 E:T Ratio/Positive Control, Blood
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.65
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98030-0 | Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC) |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer estimuladas con IL-2. Proporción efector con célula diana 3.75: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales. Efector estimulado por IL-2 3.75: |
| fr-FR | French (France) | Cytotoxicité cellules NK stimulées par IL-2 Patient 3.75/1 %: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità. rapporto IL-2 stimolato 3.75: Synonyms: Cellula natural killer, citotossicità. rapporto IL stimolato 3.75: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.IL-2 刺激型 效应细胞/靶细胞比 3.75: Synonyms: Ⅰ Ⅱ I II 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
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