Version 2.80

Term Description

This assay measures the percent of red blood cells that have complete loss of the CD59 antigen. The loss of CD59 is associated with paroxysmal nocturnal hemoglobinuria (PNH), and patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59.

Part Description

LP268509-9   Erythrocytes.CD59 complete loss
Paroxsmal nocturnal hemoglobinuria (PNH) is a condition that causes hemolytic anemia, bone marrow failure, and a proclivity to develop thrombosis. PNH occurs when the PIG-A gene of bone marrow stem cells undergoes mutation. Stems cells develop into erythrocytes (RBCs), white blood cells (WBCs), platelets, and mature cells that contain the PIG-A gene mutation, and as a result, lack a sufficient number of glycosylphosphatidylinositol-anchored protein (GPI-AP). The GPI-APs have various roles, some of which are to help to prevent RBC destruction, fight infection, and promote thrombosis.[https://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/paroxysmal_nocturnal_hemoglobinuria_PNH.html] CD14, 16, 24, and 59 are GPI-linked proteins that are used as markers for the presence of GPI, as is fluorescent aerolysin (FLAER), which binds to GPI-APs. Patients with PNH lack sufficient GPIs and therefore have reduced expression of these cell markers and FLAER compared to patients without PNH. Patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59. Source: Regenstrief LOINC

Fully-Specified Name

Component
Erythrocytes.CD59 complete loss/Cells.235a
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Long Common Name
Erythrocytes.CD59 complete loss/Erythrocytes in Blood
Short Name
RBC CD59 complete loss NFr
Display Name
Erythrocytes.CD59 complete loss/Cells.235a (Bld)
Consumer Name Alpha Get Info
CD59 complete loss red blood cells/Cells.235a, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.65
Last Updated
Version 2.79 (NAM)
Change Reason
Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
90735-2 PNH GPI-Linked WBC and RBC Ag Panel - Blood

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Pérdida completa de eritrocitos CD59/Porcentaje CD235a:Fracción numérica:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Eritrocitos CD59 pérdida completa / 100 células 235a:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) Érythrocytes CD59 perte totale/100 cellules 235a:Fraction de nombres:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Eritrociti.perdita completa CD59/Cellule.235a:NFr:Pt:Sangue:Qn:
Synonyms: Cellule.235a Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) RBC CD59 RBC perdita completa CD59 Sangue
pl-PL Polish (Poland) Erytrocyty CD59 ujemne/100 komórek CD235a:frakcja liczbowa:punkt w czasie:krew:ilościowy:
Synonyms: CD59 Erytrocyty z całkowitą utratą CD59/100 komórek 235a
zh-CN Chinese (China) 红细胞.CD59 完全丧失/细胞.235a:计数型分数:时间点:全血:定量型:
Synonyms: CD59 RBC;CD59 红细胞;RBC.CD59 CD59 完全丧失型红细胞;CD59 完全丧失性红细胞 RBC;RBCS;盘状细胞;红血球;红血细胞;血液制品 - 红细胞 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=90738-6