Log In

Term Description

This assay measures the percent of red blood cells that have complete loss of the CD59 antigen. The loss of CD59 is associated with paroxysmal nocturnal hemoglobinuria (PNH), and patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59.

Part Description

LP268509-9   Erythrocytes.CD59 complete loss
Paroxsmal nocturnal hemoglobinuria (PNH) is a condition that causes hemolytic anemia, bone marrow failure, and a proclivity to develop thrombosis. PNH occurs when the PIG-A gene of bone marrow stem cells undergoes mutation. Stems cells develop into erythrocytes (RBCs), white blood cells (WBCs), platelets, and mature cells that contain the PIG-A gene mutation, and as a result, lack a sufficient number of glycosylphosphatidylinositol-anchored protein (GPI-AP). The GPI-APs have various roles, some of which are to help to prevent RBC destruction, fight infection, and promote thrombosis.https://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/paroxysmal_nocturnal_hemoglobinuria_PNH.html CD14, 16, 24, and 59 are GPI-linked proteins that are used as markers for the presence of GPI, as is fluorescent aerolysin (FLAER), which binds to GPI-APs. Patients with PNH lack sufficient GPIs and therefore have reduced expression of these cell markers and FLAER compared to patients without PNH. Patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Erythrocytes.CD59 complete loss/Cells.235a:NFr:Pt:Bld:Qn:
Long Common Name
Erythrocytes.CD59 complete loss/Erythrocytes in Blood
Short Name
RBC CD59 complete loss NFr
Display Name
Erythrocytes.CD59 complete loss/Cells.235a (Bld)
Consumer Name Alpha Get Info
CD59 complete loss red blood cells/Cells.235a, Blood

Part Model Get Info

  • Component
    Erythrocytes.CD59 complete loss/Cells.235a
    LP445399-1
    • Analyte
      Erythrocytes.CD59 complete loss/Cells.235a
      LP445399-1
      • Component Numerator
        Erythrocytes.CD59 complete loss
        LP268509-9
        • Component Numerator Core
          Erythrocytes.CD59 complete loss
          LP268509-9
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        Cells.235a
        LP444756-3
        • Component Denominator Core
          Cells.235a
          LP444756-3
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    NFr
    LP6838-9
  • Time
    Pt
    LP6960-1
  • System
    Bld
    LP7057-5
    • System Core
      Bld
      LP7057-5
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.65
Last Updated
Version 2.79 (NAM)
Change Reason
Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
90735-2PNH GPI-Linked WBC and RBC Ag Panel - Blood

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Erytrocyty.CD59 úplná ztráta/100 buněk.235a:Početní podíl:Časový bod:Krev:Kvantitativní:
es-MXSpanish (Mexico)Eritrocitos CD59 pérdida completa / 100 células 235a:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
es-ESSpanish (Spain)Pérdida completa de eritrocitos CD59/Células 235a:Fracción numérica:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
fr-FRFrench (France)Érythrocytes CD59 perte totale/CD235a:Fraction de nombres:Ponctuel:Sang:Numérique:
it-ITItalian (Italy)Eritrociti.perdita completa CD59/Cellule.235a:NFr:Pt:Sangue:Qn:
Synonyms: Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) RBC CD59 RBC perdita completa CD59 Sangue
pl-PLPolish (Poland)Erytrocyty CD59 ujemne/komórki.235a:frakcja liczbowa:punkt w czasie:krew:ilościowy:
Synonyms: CD59
zh-CNChinese (China)红细胞.CD59 完全丧失/细胞.235a:计数型分数:时间点:全血:定量型:
Synonyms: CD59 RBC;CD59 红细胞;RBC.CD59 CD59 完全丧失型红细胞;CD59 完全丧失性红细胞 RBC;RBCS;盘状细胞;红血球;红血细胞;血液制品 - 红细胞 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=90738-6