Version 2.77

Part Description

LP281375-8   CYP3A7 gene
Many drugs are metabolized by members of the cytochrome P450 CYP3A subfamily, which present considerable variation in gene expression. CYP3A4, CYP3A5, CYP3A7 and CYP3A43 genes are included in the 231-kb CYP3A locus. Several single nucleaotide polymorphisms (SNPs) with the CYP3A5 are associated with absence of CYP3A5 expression in the liver. The CYP3A5*1 allele (A6986) appears to be the main allele associated with CYP3A5 expression and activity. Individuals with a CYP3A5*1 allele may show more rapid than average metabolism of CYP3A substrates. Carriers of the mutation CYP3A5*3 (A6986G) appear not to express the enzyme due to the creation of a cryptic splice site. Since CYP3A5 expression in the liver is likely to be a useful predictor of metabolism of a variety of drugs, PCR-based assays are performed to identify a patient's genotype for the CYP3A5*1 and CYP3A5*3 alleles. Source: Regenstrief LOINC, PMID: 12814460

Fully-Specified Name

Component
CYP3A7 gene targeted mutation analysis
Property
Find
Time
Pt
System
Bld/Tiss
Scale
Doc
Method
Molgen

Additional Names

Short Name
CYP3A7 Mut Anl Bld/T
Display Name
CYP3A7 gene targeted mutation analysis Molgen Doc (Bld/Tiss)
Consumer Name Alpha Get Info
CYP3A7 gene targeted mutation analysis, Blood or tissue specimen

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.66
Last Updated
Version 2.67
Change Reason
Release 2.67: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gen CYP3A7 Analisis de mutaciones:Hallazgo:Punto temporal:Sangre o tejido:Doc:Genética molecular
es-MX Spanish (Mexico) Análisis de mutaciones dirigidas al gen CYP3A7:Hallazgo:Punto temporal:Sangre o tejido:Documento:Genética molecular
fr-FR French (France) CYP3A7 gène mutation cible trouvée:Recherche:Ponctuel:Sang/Tissu:Document:Biologie moléculaire
it-IT Italian (Italy) CYP3A7, gene analisi di mutazione mirata:Osservazione:Pt:Sangue/Tess:Doc:Molgen
Synonyms: Farmacogenomica Genetica molecolare Osservazione Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) CYP3A7-gen doelgerichte mutatie-analyse:bevinding:moment:bloed of weefsel:document:moleculair genetisch onderzoek
Synonyms: molgen targeted
zh-CN Chinese (China) CYP3A7 基因 突变分析:发现:时间点:全血/组织:文档型:分子遗传学类实验室方法
Synonyms: 临床文档型;临床文档;文档;文书;医疗文书;临床医疗文书 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 发现是一个原子型临床观察指标，并不是作为印象的概括陈述。体格检查、病史、系统检查及其他此类观察指标的属性均为发现。它们的标尺对于编码型发现可能是名义型，而对于叙述型文本之中所报告的发现，则可能是叙述型。;发现物;所见;结果;结论 基因突变分析 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 细胞色素 P450 家族 3 亚家族 A 成员 7;细胞色素 P450, 家族 3, 亚家族 A, 多肽 7;细胞色素 P450, 亚家族 IIIA, 多肽 7;细胞色素 P450-HFLA;细胞色素 P450 3A7;黄素蛋白连接单加氧酶;黄酶连接单加氧酶;黄素蛋白单加氧酶;黄酶单加氧酶;芳基烃羟化酶;芳烃羟化酶;微粒体单加氧酶;异生物单加氧酶;外源性化学物单加氧酶;异生物质单加氧酶;Cytochrome P450 Family 3 Subfamily A Member 7;Cytochrome P45 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=91669-2