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Term Description

This test detects, but does not distinguish between, mutations in the FLT3 gene at the D835 position. If any of the variants tested for are found, the result is reported as detected.

Part Description

LP309963-9   FLT3 gene.p.Asp835
The FLT3 gene (fms-related tyrosine kinase 3) [HGNC Gene ID:3765] is located on chromosome 13q12. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] [NCBI Gene ID:2322] FLT3 mutations occur in approximately 1/3 of patients with AML. About 70% are internal tandem duplications, and the rest are due to variants in the tyrosine kinase domain of FLT3, primarily at Asp835 (D835). PMID: 17124058 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
FLT3 gene.p.Asp835 mutations:PrThr:Pt:Bld/Tiss:Ord:Molgen
Long Common Name
FLT3 gene p.Asp835 mutations found [Presence] in Blood or Tissue by Molecular genetics method
Short Name
FLT3 p.D835 Mut Bld/T Ql
Display Name
FLT3 gene D835 mutations found Molgen Ql (Bld/Tiss)
Consumer Name Alpha Get Info
FLT3 p.Asp835 Mutations mutations found, Blood or tissue specimen

Part Model Get Info

  • Component
    FLT3 gene.p.Asp835 mutations
    LP310331-6
    • Analyte
      FLT3 gene.p.Asp835 mutations
      LP310331-6
      • Component Numerator
        FLT3 gene.p.Asp835 mutations
        LP310331-6
        • Component Numerator Core
          FLT3 gene.p.Asp835
          LP309963-9
        • Component Numerator Core Suffix
          mutations
          LP452208-4
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Molgen
    LP6404-0

Preferred Answer List: LL744-4

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
DetectedLA11882-0
Not detectedLA11883-8

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.66
Last Updated
Version 2.83 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Gen FLT3 mutace p.Asp835:Přítomnost nebo práh:Časový bod:Krev/tkáň:Ordinální:Molekulární genetika
el-GRGreek (Greece)Γονίδιο FLT3.Μεταλλάξεις p.Asp835:PrThr:Pt:Αίμα/Ιστός:Ord:Μοριακή γενετική
Synonyms: MOLPATH MOLPATH.MUT Ord P PrThr Pt Αίμα Αίμα/Ιστός Γονίδιο Γονίδιο FLT3 Γονίδιο FLT3.Μεταλλάξεις p.Asp835 Ιστός Μεταλλάξεις Μοριακή γενετική
es-MXSpanish (Mexico)Mutaciones del gen FLT3 p. Asp835:Presencia o umbral:Punto temporal:Sangre o tejido:Ordinal:Genética molecular
es-ESSpanish (Spain)Mutaciones del gen FLT3 p.Asp835:PrThr:Punto temporal:Sangre o tejido:Ord:Genética molecular
fr-FRFrench (France)FLT3 gène.p.Asp835 mutations:Présence/Seuil:Ponctuel:Sang/Tissu:Qualitatif:Biologie moléculaire
it-ITItalian (Italy)FLT3, mutazioni gene.p.Asp835:PrThr:Pt:Sangue/Tess:Ord:Molgen
Synonyms: Gene FLT3 Genetica molecolare Mutazione genica Mutazioni gene FLT3 p.Asp835 Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
pl-PLPolish (Poland)FLT3 gen.p.Asp835 mutacje:granica wykrywalności:punkt w czasie:krew lub tkanka:uporządkowany:genetyka molekularna
Synonyms: diagnostyka molekularna Gen FLT3 Mutacje genu FLT3 w pozycji p.Asp835 (zamiana aminokwasu Asp na inny aminokwas w pozycji 835 białka)
zh-CNChinese (China)FLT3 基因.p.Asp835 突变:存在情况或阈值:时间点:全血/组织:序数型:分子遗传学类实验室方法
Synonyms: FL 细胞因子受体前体;FLK2;fms-相关性酪氨酸激酶 3;STK1;STK-1;干细胞酪氨酸激酶 1 FLT3 基因.p.Asp835 变异 P 型 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 突变 突变类;基因突变 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=92843-2