LOINC
Version 2.67

93339-0THSD7A IgG Ab [Presence] in Serum or Plasma by ImmunofluorescenceActive

Term Description

The immunofluorescence pattern for THSD7A antibodies is fine granular cytoplastic staining with prominence of the cell membrane. Cell nuclei should not fluoresce. This term was created for, but is not limited in use to, the EUROIMMUN Anti-THSD7A IFA test kit.
Source: Regenstrief LOINC

Part Description

LP410867-8   Thrombospondin type I domain-containing 7A
Thrombospondin type-1 domain-containing protein 7A (THSD7A) is a membrane protein that was initially characterized in placental endothelia, but is also expressed on the basal aspect of podocytes of the kidney. It has been reported to play a role in actin cytoskeletal integrity, and its soluble form has been shown to promote endothelial cell migration and filopodia formation. Autoantibodies against THSD7A have been demonstrated to be present in a small subset of patients with idiopathic/primary membranous nephropathy (MN) who do not demonstrate antibodies against the primary target in that disease, the phospholipase A2 receptor (PLA2R) [PMID: 25394321] . Source: Regenstrief LOINC

Fully-Specified Name

Component
Thrombospondin type I domain-containing 7A Ab.IgG
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
IF

Additional Names

Short Name
THSD7A IgG SerPl Ql IF
Display Name
THSD7A IgG IF Ql

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.67
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

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