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Part Description

LP410874-4   von Willebrand factor cleaving protease activity
von Willebrand factor (vWF) cleaving protease, or ADAMTS13, is a metalloprotease that cleaves vWF and thereby limits platelet aggregation and formation of microthrombi. vWF cleaving protease inhibitors can decrease the protease activity and/or more rapidly remove the enzyme from the circulation. Such inhibitors are one cause of thrombotic thrombocytopenic purpura (TTP), a disorder characterized by thrombocytopenia, anemia, fever, and neurologic and renal abnormalities. Idiopathic TTP is often due to anti-ADAMTS13 autoantibodies, while inherited TTP is an autosomal recessive disorder due to mutations in the ADAMTS13 gene that lead to impaired protease function. Work-up of patients with TTP can include vWF cleaving protease activity and, if that activity is low, inhibitor screen followed by quantification. PMID: 18756543 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
von Willebrand factor cleaving protease activity:CCnc:Pt:PPP:Qn:Chromo
Long Common Name
von Willebrand factor (vWf) cleaving protease activity [Enzymatic activity/volume] in Platelet poor plasma by Chromogenic method
Short Name
vWF Cp Act PPP Chro-cCnc
Display Name
vWf cleaving protease activity Chromogenic method (PPP) [Catalytic activity/Vol]
Consumer Name Alpha Get Info
vWf cleaving protease activity, Blood

Part Model Get Info

  • Component
    von Willebrand factor cleaving protease activity
    LP410874-4
    • Analyte
      von Willebrand factor cleaving protease activity
      LP410874-4
      • Component Numerator
        von Willebrand factor cleaving protease activity
        LP410874-4
        • Component Numerator Core
          von Willebrand factor cleaving protease activity
          LP410874-4
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    CCnc
    LP6789-4
  • Time
    Pt
    LP6960-1
  • System
    PPP
    LP7494-0
    • System Core
      PPP
      LP7494-0
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    Chromo
    LP6256-4

Basic Attributes

Class
COAG
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.68 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)von Willebrandův faktor (vWf) štěpící proteáza aktivita:Katalytická koncentrace:Časový bod:Plazma chudá na trombocyty:Kvantitativní:Chromogenní (enzymatický) test
el-GRGreek (Greece)δραστικότητα πρωτεάσης διάσπασης παράγοντα Von Willebrand:CCnc:Pt:PPP:Qn:Chromo
Synonyms: CCnc Chromo COAG PPP Pt Qn Δραστηριότητα δραστικότητα πρωτεάσης διάσπασης παράγοντα Von Willebrand παράγοντας Von Willebrand πρωτεάση διάσπασης παράγοντα Von Willebrand
es-ESSpanish (Spain)Actividad de la proteasa de escisión del factor de von Willebrand:Concentración Catalítica:Punto temporal:Plasma pobre en plaquetas:Qn:Cromogénico ( Enzima)
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Factor de von Willebrand que escinde la actividad de la proteasa:Concentración catalítica:Punto temporal:Plasma pobre en plaquetas:Cuantitativo:Cromogénico (enzima)
fr-FRFrench (France)ADAMTS 13 activité:Catalytique/Volume:Ponctuel:Plasma pauvre en plaquettes:Numérique:Technique chromogénique
it-ITItalian (Italy)von Willebrand, fattore attività proteasi di taglio:CCnC:Pt:PPP:Qn:Cromo
Synonyms: Attività della proteasi di taglio del fattore di von Willebrand Concentrazione Catalitica Cromogenico (Enzima) Fattore di von Willebrand (vWf) Plasma povero di piastrine Proteasi di taglio del fattore di von Willebrand Punto nel tempo (episodio) Studio di coagulazione
pl-PLPolish (Poland)Aktywność proteazy rozkładającej czynnik von Willebranda:stężenie katalityczne:punkt w czasie:osocze ubogopłytkowe:ilościowy:metoda z substratem chromogennym
Synonyms: ADAMTS13 Aktywność ADAMTS13 Czynnik von Willebranda (vWf) PPP
zh-CNChinese (China)von Willebrand 因子裂解蛋白酶活性:催化浓度:时间点:贫血小板血浆:定量型:凝血因子酶学测定法
Synonyms: von Willebrand von Willebrand 因子（von Willebrand Factor，vWf）;vWf;vWf 因子;血管性假血友病因子;血管性血友病因子 von Willebrand 因子（vWf 因子、血管性假血友病因子、血管性血友病因子）裂解蛋白酶;ADAMTS13;von Willebrand 因子裂解蛋白酶（von Willebrand Factor Cleaving Protease，VWF-cp）;von Willebrand 因子裂解酶;vWCP;vWf 因子裂解蛋白酶;vWf 因子裂解酶;vWf 裂解酶;VWFCP;VWF-cp;血管性血友病因子裂解蛋白酶;血管性血友病因子裂解酶 von Willebrand 因子（vWf 因子、血管性假血友病因子、血管性血友病因子）裂解蛋白酶活性 乏血小板血浆;Platelet poor plasma;PPP 催化浓度(单位体积);单位体积内酶的单位数 冯·威勒布兰德 冯威勒布兰德 冯威勒布兰德氏 凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程 凝血因子发色测定方法;凝血因子发色测定法;凝血因子酶学测定方法;发色法;发色测定方法;发色测定法;显色法;显色测定方法;显色测定法;酶学法;酶学测定方法;酶学测定法;酶法 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 因素 时刻;随机;随意;瞬间 朊酶 活动 系数 蛋白质酵素

Example Units

UnitSource
U/mLExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93371-3