Log In

Term Description

This term is intended to report the differentiation of primary mediastinal large B-cell lymphoma (PMBCL) from diffuse large B-cell lymphoma (DLBCL), and (if found to be DLBCL) to further subdivide DLBCL by cell of origin into the germinal center subtype or non-germinal center (activated B-cell) subtype.

Part Description

LP411615-0   Large B-cell lymphoma and cell of origin
Distinguishing between large B-cell lymphomas is critical because the different forms often require distinct management. Diffuse large B-cell lymphoma (DLBCL) is the most common form, making up 30-40% of all non-Hodgkin's lymphomas. DLBCL is defined pathologically by large neoplastic cells with B-cell derivation and clinically by aggressive presentation, but differs from its former putative subtype, primary mediastinal large B-cell lymphoma (PMBCL), which is believed to arise from thymic medullary B cells. Since 2001, the WHO has recognized PMBCL as a distinct clinicopathologic disease from DLBCL, with likely distinct treatment options. PMBCL accounts for approximately 2% of patients with NHL, and tends to affect younger patients. PMID: 16720849. PMBCL is generally not further subclassified during a patient workup, whereas DLBCL can be further subdivided by cell of origin (COO) into germinal center type and non-germinal center (activated B-cell) type, the latter having significantly worse response to certain treatments PMID: 25135992. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Large B-cell lymphoma and cell of origin:Type:Pt:Tiss:Nom:
Long Common Name
Large B-cell lymphoma and cell of origin [Type] in Tissue
Short Name
Lg B-cell lymph+COO Tiss
Display Name
Large B-cell lymphoma and cell of origin Nom (Tiss)
Consumer Name Alpha Get Info
Large b-cell lymphoma and cell of origin, Tissue

Part Model Get Info

  • Component
    Large B-cell lymphoma and cell of origin
    LP411615-0
    • Analyte
      Large B-cell lymphoma and cell of origin
      LP411615-0
      • Component Numerator
        Large B-cell lymphoma and cell of origin
        LP411615-0
        • Component Numerator Core
          Large B-cell lymphoma and cell of origin
          LP411615-0
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Type
    LP6886-8
  • Time
    Pt
    LP6960-1
  • System
    Tiss
    LP7641-6
    • System Core
      Tiss
      LP7641-6
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    NULL
     

Preferred Answer List: LL5436-2

AnswerCodeScoreAnswer ID
Primary mediastinal large B-cell lymphoma (PMBCL)LA30366-1
Germinal center B-cell type of diffuse large B-cell lymphomaLA30367-9
Activated B-cell type of diffuse large B-cell lymphomaLA30368-7
Unclear or unknownLA10109-9

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.67 (ADD)
Order vs. Observation
Observation

Member of these Panels

LOINCLong Common Name
93785-4Large B-cell lymphoma classification panel - Tissue

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)B-lymfom velkobuněčný a buňky původu:Typ:Časový bod:Tkáně a stěry:Nominální:
el-GRGreek (Greece)Λέμφωμα μεγάλων Β-κυττάρων και κύτταρο προέλευσης:Type:Pt:Ιστός:Nom:
Synonyms: B Nom PATH Pt Type Β κύτταρο Ιστός Λέμφωμα μεγάλων Β-κυττάρων Λέμφωμα μεγάλων Β-κυττάρων και κύτταρο προέλευσης Προέλευση
es-ESSpanish (Spain)Linfoma de células B grandes y células de origen:Tipo:Punto temporal:Tejido:Nom:
es-MXSpanish (Mexico)Linfoma de células B grandes y células de origen:Tipo:Punto temporal:Tejido y frotis:Nominal:
it-ITItalian (Italy)Linfoma a grandi cellule B e cellula di origine:Tipo:Pt:Tessuto:Nom:
Synonyms: Patologia Punto nel tempo (episodio) Tessuto & Strisci
pl-PLPolish (Poland)Chłoniak z komórek B wg COO:typ:punkt w czasie:tkanka i rozmazy:skala nominalna:
Synonyms: Chłoniak z komórek B wg klasyfikacji Cell of Origin (COO) Pochodzenie wynik kategorialny
zh-CNChinese (China)大B细胞淋巴瘤和细胞起源:类型:时间点:组织与涂片:名义型:
Synonyms: B 型 B 细胞 B-细胞 LBCL 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 型 大B细胞淋巴瘤（LBCL）和细胞起源 成因;来源 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93779-7