Version 2.78

Term Description

This term is intended to report the differentiation of primary mediastinal large B-cell lymphoma (PMBCL) from diffuse large B-cell lymphoma (DLBCL), and (if found to be DLBCL) to further subdivide DLBCL by cell of origin into the germinal center subtype or non-germinal center (activated B-cell) subtype.
Source: Regenstrief LOINC

Part Description

LP411615-0   Large B-cell lymphoma and cell of origin
Distinguishing between large B-cell lymphomas is critical because the different forms often require distinct management. Diffuse large B-cell lymphoma (DLBCL) is the most common form, making up 30-40% of all non-Hodgkin's lymphomas. DLBCL is defined pathologically by large neoplastic cells with B-cell derivation and clinically by aggressive presentation, but differs from its former putative subtype, primary mediastinal large B-cell lymphoma (PMBCL), which is believed to arise from thymic medullary B cells. Since 2001, the WHO has recognized PMBCL as a distinct clinicopathologic disease from DLBCL, with likely distinct treatment options. PMBCL accounts for approximately 2% of patients with NHL, and tends to affect younger patients. PMID: 16720849. PMBCL is generally not further subclassified during a patient workup, whereas DLBCL can be further subdivided by cell of origin (COO) into germinal center type and non-germinal center (activated B-cell) type, the latter having significantly worse response to certain treatments PMID: 25135992. Source: Regenstrief LOINC

Fully-Specified Name

Component
Large B-cell lymphoma and cell of origin
Property
Type
Time
Pt
System
Tiss
Scale
Nom
Method

Additional Names

Short Name
Lg B-cell lymph+COO Tiss
Display Name
Large B-cell lymphoma and cell of origin Nom (Tiss)
Consumer Name Alpha Get Info
Large b-cell lymphoma and cell of origin, Tissue

Preferred Answer List: LL5436-2

Answer Code Score Answer ID
Primary mediastinal large B-cell lymphoma (PMBCL) LA30366-1
Germinal center B-cell type of diffuse large B-cell lymphoma LA30367-9
Activated B-cell type of diffuse large B-cell lymphoma LA30368-7
Unclear or unknown LA10109-9

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.67
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
93785-4 Large B-cell lymphoma classification panel - Tissue

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Linfoma de células B grandes y células de origen:Tipo:Punto temporal:Tejido:Nom:
es-MX Spanish (Mexico) Linfoma de células B grandes y células de origen:Tipo:Punto temporal:Tejido y frotis:Nominal:
it-IT Italian (Italy) Linfoma a grandi cellule B e cellula di origine:Tipo:Pt:Tessuto:Nom:
Synonyms: Patologia Punto nel tempo (episodio) Tessuto & Strisci
pl-PL Polish (Poland) Chłoniak z komórek B wg COO:typ:punkt w czasie:tkanka i rozmazy:cecha:
Synonyms: Chłoniak z komórek B wg klasyfikacji Cell of Origin (COO) Pochodzenie
zh-CN Chinese (China) 大B细胞淋巴瘤和细胞起源:类型:时间点:组织与涂片:名义型:
Synonyms: B 型 B 细胞 B-细胞 LBCL 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 型 大B细胞淋巴瘤（LBCL）和细胞起源 成因;来源 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93779-7