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Term Description

This panel is intended to be ordered when differentiating between subtypes of large B-cell lymphoma, including diffuse large B Cell lymphoma (DLBCL) or primary mediastinal B cell lymphoma (PMBL). If the type is determined to be DLBCL, further testing may be performed to determine the cell of origin as either activated B-cell or germinal center B-cell. Different methods for classification may be used, including immunohistochemistry, gene expression profiling, and LymphCx, a Nanostring technology.

Part Description

LP411616-8   Large B-cell lymphoma classification panel
Distinguishing between large B-cell lymphomas is critical because the different forms often require distinct management. Diffuse large B-cell lymphoma (DLBCL) is the most common form, making up 30-40% of all non-Hodgkin's lymphomas. DLBCL is defined pathologically by large neoplastic cells with B-cell derivation and clinically by aggressive presentation, but differs from its former putative subtype, primary mediastinal large B-cell lymphoma (PMBCL), which is believed to arise from thymic medullary B cells. Since 2001, the WHO has recognized PMBCL as a distinct clinicopathologic disease from DLBCL, with likely distinct treatment options. PMBCL accounts for approximately 2% of patients with NHL, and tends to affect younger patients. PMID: 16720849. PMBCL is generally not further subclassified during a patient workup, whereas DLBCL can be further subdivided by cell of origin (COO) into germinal center type and non-germinal center (activated B-cell) type, the latter having significantly worse response to certain treatments PMID: 25135992. Source: Regenstrief LOINC

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINCNameR/O/CCardinalityExample UCUM Units
93785-4Large B-cell lymphoma classification panel - Tissue
Indent93779-7Large B-cell lymphoma and cell of origin [Type] in Tissue
Indent93780-5Primary mediastinal large B-cell lymphoma [Likelihood] in Tissue{risk}
Indent93782-1Large B-cell lymphoma [Type] in Tissue
Indent93784-7Diffuse large B-Cell lymphoma cell of origin subclassification panel - Tissue
IndentIndent93781-3Diffuse large B-cell lymphoma.activated B-cell subtype [Likelihood] in Tissue{risk}
IndentIndent93783-9Diffuse large B-cell lymphoma cell of origin [Type] in Tissue

LOINC Names Get Info

Fully-Specified Name
Large B-cell lymphoma classification panel:-:Pt:Tiss:-:
Long Common Name
Large B-cell lymphoma classification panel - Tissue
Short Name
Lg B-cell Lymph Pnl Tiss
Display Name
Large B-cell lymphoma classification panel (Tiss)
Consumer Name Alpha Get Info
Large b-cell lymphoma classification panel, Tissue

Part Model Get Info

  • Component
    Large B-cell lymphoma classification panel
    LP411616-8
    • Analyte
      Large B-cell lymphoma classification panel
      LP411616-8
      • Component Numerator
        Large B-cell lymphoma classification panel
        LP411616-8
        • Component Numerator Core
          Large B-cell lymphoma classification panel
          LP411616-8
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    -
    LP6769-6
  • Time
    Pt
    LP6960-1
  • System
    Tiss
    LP7641-6
    • System Core
      Tiss
      LP7641-6
    • Super System
      NULL
       
  • Scale
    -
    LP7747-1
  • Method
    NULL
     

Basic Attributes

Class
PANEL.PATH
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.67 (ADD)
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)B-lymfom refrakterní difúzní velkobuněčný panel:-:Časový bod:Tkáně a stěry:-:
el-GRGreek (Greece)Πίνακας ταξινόμησης λεμφώματος μεγάλων Β-κυττάρων:-:Pt:Ιστός:-:
Synonyms: - B PANEL.PATH PATH Pt Β κύτταρο Ιστός Λέμφωμα μεγάλων Β-κυττάρων Πίνακας ταξινόμησης λεμφώματος μεγάλων Β-κυττάρων
es-ESSpanish (Spain)Panel de clasificación de linfomas de células B grandes:Propiedades mixtas (sólo paneles):Punto temporal:Tejido:-:
es-MXSpanish (Mexico)Panel de clasificación de linfomas de células B grandes:-:Punto temporal:Tejido y frotis:-:
it-ITItalian (Italy)Linfoma a grandi cellule B, panel classificazione:-:Pt:Tessuto:-:
Synonyms: Panel classificazione di linfoma a grandi cellule B Patologia Punto nel tempo (episodio) Set di prescrizione per patologia Tessuto & Strisci
pl-PLPolish (Poland)Klasyfikacja chłoniaka z dużych komórek B, panel:-:punkt w czasie:tkanka i rozmazy:-:
Synonyms: Klasyfikacja chłoniaka z dużych komórek B, panel
zh-CNChinese (China)大B细胞淋巴瘤分类组套:-:时间点:组织与涂片:-:
Synonyms: B 型 B 细胞 B-细胞 LBCL 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组.病理学;病理学组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目） 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 多重;多重型;多重标尺类型;多重精度类型 大B细胞淋巴瘤（LBCL）分类组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目） 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 组 组合 组合医嘱 组合类 组套

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93785-4
Questionnaire definition
https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/93785-4