Version 2.78

Term Description

This panel is intended to be ordered when differentiating between subtypes of large B-cell lymphoma, including diffuse large B Cell lymphoma (DLBCL) or primary mediastinal B cell lymphoma (PMBL). If the type is determined to be DLBCL, further testing may be performed to determine the cell of origin as either activated B-cell or germinal center B-cell. Different methods for classification may be used, including immunohistochemistry, gene expression profiling, and LymphCx, a Nanostring technology.
Source: Regenstrief LOINC

Part Description

LP411616-8   Large B-cell lymphoma classification panel
Distinguishing between large B-cell lymphomas is critical because the different forms often require distinct management. Diffuse large B-cell lymphoma (DLBCL) is the most common form, making up 30-40% of all non-Hodgkin's lymphomas. DLBCL is defined pathologically by large neoplastic cells with B-cell derivation and clinically by aggressive presentation, but differs from its former putative subtype, primary mediastinal large B-cell lymphoma (PMBCL), which is believed to arise from thymic medullary B cells. Since 2001, the WHO has recognized PMBCL as a distinct clinicopathologic disease from DLBCL, with likely distinct treatment options. PMBCL accounts for approximately 2% of patients with NHL, and tends to affect younger patients. PMID: 16720849. PMBCL is generally not further subclassified during a patient workup, whereas DLBCL can be further subdivided by cell of origin (COO) into germinal center type and non-germinal center (activated B-cell) type, the latter having significantly worse response to certain treatments PMID: 25135992. Source: Regenstrief LOINC

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
93785-4 Large B-cell lymphoma classification panel - Tissue
Indent93779-7 Large B-cell lymphoma and cell of origin [Type] in Tissue
Indent93780-5 Primary mediastinal large B-cell lymphoma [Likelihood] in Tissue {risk}
Indent93782-1 Large B-cell lymphoma [Type] in Tissue
Indent93784-7 Diffuse large B-Cell lymphoma cell of origin subclassification panel - Tissue
IndentIndent93781-3 Diffuse large B-cell lymphoma.activated B-cell subtype [Likelihood] in Tissue {risk}
IndentIndent93783-9 Diffuse large B-cell lymphoma cell of origin [Type] in Tissue

Fully-Specified Name

Component
Large B-cell lymphoma classification panel
Property
-
Time
Pt
System
Tiss
Scale
-
Method

Additional Names

Short Name
Lg B-cell Lymph Pnl Tiss
Display Name
Large B-cell lymphoma classification panel (Tiss)
Consumer Name Alpha Get Info
Large b-cell lymphoma classification panel, Tissue

Basic Attributes

Class
PANEL.PATH
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.67
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Panel de clasificación de linfomas de células B grandes:Propiedades mixtas (sólo paneles):Punto temporal:Tejido:-:
es-MX Spanish (Mexico) Panel de clasificación de linfomas de células B grandes:-:Punto temporal:Tejido y frotis:-:
it-IT Italian (Italy) Linfoma a grandi cellule B, panel classificazione:-:Pt:Tessuto:-:
Synonyms: Panel classificazione di linfoma a grandi cellule B Patologia Punto nel tempo (episodio) Set di prescrizione per patologia Tessuto & Strisci
pl-PL Polish (Poland) Klasyfikacja chłoniaka z dużych komórek B, panel:-:punkt w czasie:tkanka i rozmazy:-:
Synonyms: Klasyfikacja chłoniaka z dużych komórek B, panel
zh-CN Chinese (China) 大B细胞淋巴瘤分类组套:-:时间点:组织与涂片:-:
Synonyms: B 型 B 细胞 B-细胞 LBCL 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组.病理学;病理学组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目） 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 多重;多重型;多重标尺类型;多重精度类型 大B细胞淋巴瘤（LBCL）分类组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目） 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 组 组合 组合医嘱 组合类 组套

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93785-4
Questionnaire definition
https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/93785-4