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Term Description

Bone marrow or tumor tissue are the common specimens for this test. If these are not available, a blood specimen may be used if there are malignant cells present in the blood (as verified by hematopathology).

Part Descriptions

LP411834-7   MYCN gene amplification
MYCN gene amplification studies evaluate the number of copies of the MYCN gene present in a single cell to aid in determining the prognosis of neurobastoma (NBL) patients. The MYCN gene encodes for a protein involved in the formation of tissues and organs during fetal development. It can also be an oncogene that regulates gene transcription. Amplification is determined based on the MYCN gene copy number and MYCN to centromere ratio (CEP2). An MYCN/CEP2 ratio of >= 2.0 is an indication of aggressive tumor progression of neuroblastoma. PMID: 9779703 Source: Regenstrief LOINC

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

LOINC Names Get Info

Fully-Specified Name
MYCN gene amplification:Find:Pt:Bld/Tiss:Doc:FISH
Long Common Name
MYCN gene amplification in Blood or Tissue by FISH
Short Name
MYCN amplification Bld/T FISH
Display Name
MYCN gene amplification FISH Doc (Bld/Tiss)
Consumer Name Alpha Get Info
MYCN gene amplification, Blood or tissue specimen

Part Model Get Info

  • Component
    MYCN gene amplification
    LP411834-7
    • Analyte
      MYCN gene amplification
      LP411834-7
      • Component Numerator
        MYCN gene amplification
        LP411834-7
        • Component Numerator Core
          MYCN gene amplification
          LP411834-7
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Find
    LP6813-2
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Doc
    LP32888-7
  • Method
    FISH
    LP62864-1

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.68 (MAJ)
Change Reason
Release 2.68: SYSTEM: Updated since testing can be done on blood, although bone marrow or tissue is the preferred specimen.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Gen MYCN amplifikace:Nález:Časový bod:Krev/tkáň:Dokument:Fluorescenční in situ hybridizace (FISH)
el-GRGreek (Greece)Ενίσχυση του γονιδίου MYCN:Εύρεση:Pt:Αίμα/Ιστός:Doc:Φθορίζουσα υβριδοποίηση in situ
Synonyms: Doc MOLPATH Pt Αίμα Αίμα/Ιστός Γονίδιο Ενίσχυση του γονιδίου MYCN Εύρεση Ιστός Φθορίζουσα υβριδοποίηση in situ
es-ESSpanish (Spain)Amplificación del gen MYCN:Hallazgo:Punto temporal:Sangre o tejido:Doc:Hibridación in situ fluoresente (FISH)
es-MXSpanish (Mexico)Amplificación del gen MYCN:Hallazgo:Punto temporal:Sangre o tejido:Documento:Hibridación fluorescente in situ (FISH)
fr-FRFrench (France)MYCN gène amplification:Recherche:Ponctuel:Sang/Tissu:Document:FISH
it-ITItalian (Italy)MYCN, amplificazione gene:Osservazione:Pt:Sangue/Tess:Doc:FISH
Synonyms: Amplificazione del gene MYCN Ibridazione in situ fluorescente (FISH) Osservazione Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NLDutch (Netherlands)MYCN-genamplicatie:bevinding:moment:bloed of weefsel:document:FISH
pl-PLPolish (Poland)Amplifikacja genu MYCN:stwierdzenie:punkt w czasie:krew lub tkanka:dokument:FISH
Synonyms: fluorescencyjna hybrydyzacja in situ
zh-CNChinese (China)MYCN 基因扩增:发现:时间点:全血/组织:文档型:FISH
Synonyms: Fluorescent in situ hybridization;荧光原位杂交 MYCN 原癌基因, BHLH 转录因子;MYCN Proto-Oncogene, BHLH Transcription Factor 临床文档型;临床文档;文档;文书;医疗文书;临床医疗文书 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 发现是一个原子型临床观察指标，并不是作为印象的概括陈述。体格检查、病史、系统检查及其他此类观察指标的属性均为发现。它们的标尺对于编码型发现可能是名义型，而对于叙述型文本之中所报告的发现，则可能是叙述型。;发现物;所见;结果;结论 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93796-1