LOINC
Version 2.71

94266-4CD11a, CD11b, and CD18 phenotyping panel - Blood QualitativeActive

Term Description

Flow cytometric immunophenotyping evaluation for presence or absence of the CD11/CD18 complex using monoclonal antibodies directed against the CD11 isoforms, CD11a and CD11b, and CD18 antigens. Defects in CD18 expression lead to either very low or no surface membrane expression of alpha chains CD11a, CD11b, and CD11c. Testing is performed for the diagnosis of leukocyte adhesion deficiency syndrome type 1 (LAD-1), an autosomal recessive disorder caused by mutations in the common chain (CD18) of the beta2-integrin family.
Source: Regenstrief LOINC

Part Descriptions

LP417291-4   CD11a & CD11b & CD18 phenotyping panel
LAD-1 is clinically characterized by recurrent infections, impaired wound healing, delayed umbilical cord separation, persistent leukocytosis, and recurrent soft tissue and oral infections. Each of the beta2-integrins is a heterodimer composed of an alpha chain (CD11a, CD11b, or CD11c) noncovalently linked to a common beta2-subunit (CD18). The alpha-beta heterodimers of the beta2-integrin family include LFA-1 (CD11a/CD18), Mac-1/CR3 (CD11b/CD18), and p150/95 (CD11c/CD18).(1-4) The CD18 gene, ITGB2, and its product are required for normal expression of the alpha-beta heterodimers. Therefore, defects in CD18 expression lead to either very low or no surface membrane expression of CD11a, CD11b, and CD11c. Copyright Copyright © 1995-2009 Source: Mayo Medical Laboratories

LP18359-7   CD11b
Found on myeloid cells and NK-cells
Associated with some AML Source: Regenstrief LOINC

LP20054-0   CD11a
CD11a is found on all leukocytes and may be absent in B-cell neoplasms, including Burkitts lymphoma and Hairy cell leukemia. Source: Regenstrief LOINC

Panel Hierarchy
Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
94266-4 CD11a, CD11b, and CD18 phenotyping panel - Blood Qualitative
Indent94268-0 CD11a cells [Presence] in Blood
Indent94267-2 CD11b cells [Presence] in Blood
Indent94265-6 CD18 cells [Presence] in Blood

Fully-Specified Name

Component
CD11a & CD11b & CD18 phenotyping panel
Property
-
Time
Pt
System
Bld
Scale
Ord
Method

Additional Names

Short Name
CD11a + CD11b + CD18 Pnl Bld
Display Name
CD11a, CD11b, and CD18 phenotyping panel Ql (Bld)
Consumer Name Alpha
CD11a, CD11b, and CD18 phenotyping panel, Blood

Basic Attributes

Class
PANEL.CELLMARK
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

zh-CNChinese (China)
CD11a 与 CD11b 与 CD18 表现型分型组套:-:时间点:全血:序数型:
nl-NLDutch (Netherlands)
CD11a & CD11b & CD18 fenotypering panel:-:moment:bloed:ordinaal:
fr-FRFrench (France)
CD11a et CD11b et CD18 phénotypage panel:-:Ponctuel:Sang:Qualitatif:
it-ITItalian (Italy)
CD11a & CD11b & CD18, panel fenotipizzazione:-:Pt:Sangue:Ord:
es-ESSpanish (Spain)
Panel de fenotipado de CD11a, CD11b y CD18:Propiedades mixtas (sólo paneles):Punto temporal:Sangre:Ord:

LOINC FHIR® API Example - CodeSystem and Questionnaire Requests Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94266-4 https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/94266-4