94692-1
Dermatan sulfate/Creatinine [Ratio] in Urine
Active
Part Descriptions
LP15532-2 Dermatan sulfate
Dermatan sulfate is a derived disaccharide that accumulates in lysosomes, extracellular matrix, and body fluids of people with mucopolysaccharidoses (MPSs). MPSs are rare disorders caused by a deficiency of enzymes that break down glycosaminoglycans (GAGs). Symptoms of MPS vary due to which storage product accumulates and the level of enzymatic function or concentration that remains. Symptoms include musculoskeletal, airway, cardiac, and central nervous system disorders. Treatments include hematopoietic stem cell transplantation for the more critical forms of MPS and intravenous enzyme replacement therapy for the others. Treatment is most effective when it is initiated before irreversible tissue damage has occurred. Because MPS is so rare and the symptoms so variable, it is difficult to diagnose in its earliest stages. A solution to that problem is the development of newborn screening assays that can detect dermatan sulfate, though the levels in the dried blood spot samples do not appear to predict the severity of disease. The pattern of dermatan and heparan sulfate can help distinguish between the different MPSs. PMID: 23084433
Source: Regenstrief LOINC
LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas.
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database, Creatinine
Fully-Specified Name
- Component
- Dermatan sulfate/Creatinine
- Property
- Ratio
- Time
- Pt
- System
- Urine
- Scale
- Qn
- Method
Additional Names
- Short Name
- Dermatan Sulfate/Creat Ur-Rto
- Display Name
- Dermatan sulfate/Creatinine (U) [Ratio]
- Consumer Name Alpha Get Info
- Dermatan sulfate/Creatinine, Urine
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.68
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 94691-3 | Dermatan sulfate, heparan sulfate, chondroitin-6-sulfate, keratan sulfate panel - Urine |
| 105125-9 | Lysosomal storage disorders screen panel - Urine |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Dermatan sulfato/Creatinina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Dermatan sulfato / Creatinina: |
| et-EE | Estonian (Estonia) | Dermataansulfaat/kreatiniin: Synonyms: Juhuslik Kvantitatiivne Uriin |
| fr-FR | French (France) | Dermatane sulfate/créatinine: |
| fr-BE | French (Belgium) | Dermatane-sulfate/Créatinine: Synonyms: SO4 |
| fr-CA | French (Canada) | Dermatane-sulfate/Créatinine: |
| it-IT | Italian (Italy) | Dermatan solfato/Creatinina: Synonyms: Chimica Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | dermatansulfaat/creatinine: Synonyms: kreatinine |
| ru-RU | Russian (Russian Federation) | Дерматан сульфат/Креатинин: Synonyms: Дерматансульфат Количественный Коэффициент; |
| tr-TR | Turkish (Turkey) | Dermatan sülfat/Kreatinin: |
| zh-CN | Chinese (China) | 硫酸皮肤素/肌酐: Synonyms: CR; |
Example Units
| Unit | Source |
|---|---|
| mg/mmol{creat} | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright