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Part Descriptions

LP171716-6   Murray Valley encephalitis virus
Murray Valley encephalitis virus (MVEV) is a zoonotic flavivirus endemic to northern Australia and New Guinea and is the causal agent of Murray Valley encephalitis. MVEV is related to West Nile virus Kunjin strain but is more virulent for humans compared to West Nile Kunjin. The majority of MVEV infections are asymptomatic or cause a non-specific febrile illness that may be associated with headache, myalgias and rash, but approximately 1 out of 150 to 1000 MVEV infections result in clinical encephalitis. The incubation period is one to four weeks, and patients with encephalitis usually present with fever, headache, malaise, and altered mental status. Complications include progressive neurological deterioration, parkinsonian tremor, cranial nerve palsies, peripheral neuropathy, coma, and flaccid paralysis. The reported case fatality rate of human MVEV encephalis is between 15-30%. PMID: 24466360 Laboratory confirmation of a suspected MVEV infection requires either the isolation of the virus itself, detection of MVEV RNA, a fourfold rise in the IgG titer between acute and convalescent serum samples, or detection of IgM in serum or CSF (in the absence of cross-reactive antibodies). PMID: 22432670 Source: Regenstrief LOINC

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Murray Valley encephalitis virus Ab.Neut:Titr:Pt:XXX:SemiQn:Neut
Long Common Name
Murray Valley encephalitis virus neutralizing antibody [Titer] in Specimen by Neutralization test
Short Name
MVEV NAb Titr Spec Nt
Display Name
MVEV neut ab Neut test (Specimen) [Titer]
Consumer Name Alpha Get Info
MVEV neutralizing antibody, Specimen

Part Model Get Info

  • Component
    Murray Valley encephalitis virus Ab.Neut
    LP430432-7
    • Analyte
      Murray Valley encephalitis virus Ab.Neut
      LP430432-7
      • Component Numerator
        Murray Valley encephalitis virus Ab.Neut
        LP430432-7
        • Component Numerator Core
          Murray Valley encephalitis virus
          LP171716-6
        • Component Numerator Core Suffix
          Ab.Neut
          LP207365-0
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Titr
    LP6881-9
  • Time
    Pt
    LP6960-1
  • System
    XXX
    LP7735-6
    • System Core
      XXX
      LP7735-6
    • Super System
      NULL
       
  • Scale
    SemiQn
    LP436123-6
  • Method
    Neut
    LP6416-4

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.75 (MAJ)
Change Reason
Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.;
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Virus encefalitidy Murray Valley Ab.neutralizační:Arbitrární koncentrace (titr):Časový bod:XXX:Semikvantitativní:Neutralizační test
el-GRGreek (Greece)Ιός εγκεφαλίτιδας κοιλάδας Murray Ab.Neut:Titr:Pt:XXX:Ημιποσοτική:Ουδετερόφιλα
Synonyms: Ab.Neut MICRO Pt Titr XXX Αντίσωμα Ημιποσοτική Ιός Ιός εγκεφαλίτιδας κοιλάδας Murray Ουδετερόφιλα
es-ESSpanish (Spain)Virus de la encefalitis del Valle Murray Anticuerpos antineutrófilos:Titulo / Factor de dilución:Punto temporal:XXX:Semicuantitativo:Prueba de neutralización
Synonyms: Semicuantitativo
es-MXSpanish (Mexico)Virus de la encefalitis del valle de Murray Ab:Título:Punto temporal:XXX:Cuantitativo:Prueba de neutralización
fr-FRFrench (France)Encéphalite de la vallée de Murray virus Ac neutralisant:Titre:Ponctuel:Milieux divers:Semi-Quantitatif:Neutralisation
it-ITItalian (Italy)Virus dell'encefalite di Murray Valley Ab.Neut:Titr:Pt:XXX:SemiQn:Neut
Synonyms: anticorpo Microbiologia Punto nel tempo (episodio) Test di neutralizzazione Titolo
nl-NLDutch (Netherlands)'Murray Valley'-encefalitisvirus As.neutraliserend:titer:moment:XXX:semikwantitatief:neutralisatietest
Synonyms: antistof; antilichaam MVE-virus
pl-PLPolish (Poland)Wirus zapalenia mózgu Murray Valley Ab.Neutralizujące:miano:punkt w czasie:XXX:półilościowy:test neutralizacji
Synonyms: Przeciwciała do wirusa zapalenia mózgu Murray Valley Przeciwciała neutralizujące do wirusa zapalenia mózgu Murray Valley Wirus zapalenia mózgu Murray Valley
zh-CNChinese (China)墨累山谷脑炎病毒 抗体.中和:滴定度:时间点:XXX:半定量型:中和试验
Synonyms: Ab;自身抗体 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项 中和试验;中和抗体;中和 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 墨累谷脑炎病毒;墨累河谷脑炎病毒;默里谷脑炎病毒;墨累山谷脑炎蚊传病毒;MVEV 大脑炎 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 脑炎（Encephalitis，大脑炎） 脑脊髓炎 脑脊髓炎（Encephalomyelitis）

Example Units

UnitSource
{titer}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=95645-8