95917-1

Histoplasma capsulatum DNA [Presence] in Lower respiratory specimen by NAA with probe detection

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Part Description

LP16650-1 Histoplasma capsulatum
Histoplasmosis capsulatum is a dimorphic fungal pathogen with filamentous or yeast forms,depending on nutritional factors and temperature.The M antigen is a well-known glycoprotein used as a diagnostic antigen for acute histoplasmosis as it induces the first precipitins during disease. Monoclonal antibodies (mAbs) to the M antigen have been found to modify the pathogenesis of histoplasmosis.Given the shortcomings of current therapies, the administration of mAbs is being investigated. PMID: 22347215 The H band is less commonly seen than the M band and is indicative of chronic or severe acute infections with H capsulatum.

H. capsulatum is found in nature primarily as a saprophytic mold. The mold form is comprised of hyaline septate hyphae, which produce two different asexual reproduction structures, macroconidia and microconidia. The micronidia are believed to be responsible for disease propagation since their 2-6 µm size is well suited for disposition into the distal alveoli. Infection is typically acquired through inhalation of fungal propagules upon disturbances of contaminated soil or excreta. Environmental and genetic factors influence disease manifestations which can range from asymptomatic or mild influenza-like disease to a disseminated sepsis form. Manifestations depend on the magnitude of exposure, the host's immunological status and the virulence of the infective strain. Reactivation of latent infection can result in significant disease, particularly for immunosuppressed individuals. Despite the availability of potent antifungal drugs, nearly one in ten patients hospitalized with histoplasmosis dies. PMID: 17223625 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Histoplasma capsulatum DNA:PrThr:Pt:Respiratory system specimen.lower:Ord:Probe.amp.tar
Long Common Name: Histoplasma capsulatum DNA [Presence] in Lower respiratory specimen by NAA with probe detection
Short Name: H capsul DNA Lower resp Ql NAA+probe
Display Name: H. capsulatum DNA NAA+probe Ql (Lower resp)
Consumer Name Alpha Get Info: Histoplasma capsulatum, Lower respiratory

Part Model Get Info

Component
Histoplasma capsulatum DNA
LP38410-4
- Analyte
  Histoplasma capsulatum DNA
  LP38410-4
  - Component Numerator
    Histoplasma capsulatum DNA
    LP38410-4
    - Component Numerator Core
      Histoplasma capsulatum
      LP16650-1
    - Component Numerator Core Suffix
      DNA
      LP32416-7
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Respiratory system specimen.lower
LP438102-8
- System Core
  Respiratory system specimen.lower
  LP438102-8
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Probe.amp.tar
LP6464-4

Example Answer List: LL3987-6

Source: New York State Health (Wadsworth Center)

Answer	Code	Score	Answer ID
Detected			LA11882-0
Not detected			LA11883-8
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value)			LA11884-6

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.69
Last Updated: Version 2.77 (MAJ)
Change Reason: Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC;
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
95919-7	Fungal pathogens panel - Lower respiratory specimen by NAA with probe detection

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Histoplasma capsulatum DNA:Přítomnost nebo práh:Časový bod:Vzorek dolních cest dýchacích:Ordinální:Amplifikace nukleových kyselin s detekcí sondou
el-GR	Greek (Greece)	Histoplasma capsulatum (Ιστόπλασμα) DNA:PrThr:Pt:Δείγμα αναπνευστικού συστήματος.κατώτερο:Ord:Ανιχνευτής.ενίσχυση.στόχου Synonyms: DNA Histoplasma capsulatum (Ιστόπλασμα) MICRO Ord PrThr Pt Αναπνευστικό Αναπνευστικό σύστημα Ανιχνευτής Ανιχνευτής.ενίσχυση Ανιχνευτής.ενίσχυση.στόχου Δείγμα Δείγμα αναπνευστικού συστήματος Δείγμα αναπνευστικού συστήματος.κατώτερο
es-ES	Spanish (Spain)	Histoplasma capsulatum ADN:PrThr:Punto temporal:Muestra de vías respiratorias inferiores:Ord:Sonda con amplificación dirigida Synonyms: Muestra del tracto respiratorio Muestra respiratoria Tracto respiratorio
es-MX	Spanish (Mexico)	ADN de Histoplasma capsulatum:Presencia o umbral:Punto temporal:Muestra de vías respiratorias inferiores:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR	French (France)	Histoplasma capsulatum ADN:Présence/Seuil:Ponctuel:Échantillon du système respiratoire inférieur:Qualitatif:PCR amplification de cible
it-IT	Italian (Italy)	Histoplasma capsulatum DNA:PrThr:Pt:Campione da Sistema Respiratorio.inferiore:Ord:Sonda.amp.tar Synonyms: Campione da Apparato Respiratorio Campione da apparato respiratorio inferiore Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL	Dutch (Netherlands)	Histoplasma capsulatum DNA:aanwezigheid:moment:onderste luchtwegen:ordinaal:probe-detectie Synonyms: onderste ademhalingsstelsel; systema respiratorium inferior probe.amp.tar systema respiratorium; ademhalingsstelsel
zh-CN	Chinese (China)	荚膜组织胞浆菌 DNA:存在情况或阈值:时间点:呼吸系统标本.下:序数型:探针法.基因扩增.靶向 Synonyms: 下下的下部低级低级的供检查用的材料;待检物;待试验物;样品;样本;试料;试样依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向去氧核糖核酸;脱氧核糖核酸去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA）受检物呼吸系统（呼吸道）标本.下;下呼吸系统标本;下呼吸道标本呼吸道标本（样品、样本）;呼吸系统标本（样品、样本）存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间样品样本皮疽组织胞浆菌 DNA 皮疽组织胞浆菌;美洲型组织胞浆菌;鼻疽性组织浆菌组织胞浆菌属组织胞浆菌病经过扩增的美洲型组织胞浆菌 DNA 脱氧核糖核酸探针试样较低较低的鼻疽性组织浆菌 DNA

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.