Version 2.78

Part Description

LP16650-1   Histoplasma capsulatum
Histoplasmosis capsulatum is a dimorphic fungal pathogen with filamentous or yeast forms,depending on nutritional factors and temperature.The M antigen is a well-known glycoprotein used as a diagnostic antigen for acute histoplasmosis as it induces the first precipitins during disease. Monoclonal antibodies (mAbs) to the M antigen have been found to modify the pathogenesis of histoplasmosis.Given the shortcomings of current therapies, the administration of mAbs is being investigated. PMID: 22347215 The H band is less commonly seen than the M band and is indicative of chronic or severe acute infections with H capsulatum.

H. capsulatum is found in nature primarily as a saprophytic mold. The mold form is comprised of hyaline septate hyphae, which produce two different asexual reproduction structures, macroconidia and microconidia. The micronidia are believed to be responsible for disease propagation since their 2-6 µm size is well suited for disposition into the distal alveoli. Infection is typically acquired through inhalation of fungal propagules upon disturbances of contaminated soil or excreta. Environmental and genetic factors influence disease manifestations which can range from asymptomatic or mild influenza-like disease to a disseminated sepsis form. Manifestations depend on the magnitude of exposure, the host's immunological status and the virulence of the infective strain. Reactivation of latent infection can result in significant disease, particularly for immunosuppressed individuals. Despite the availability of potent antifungal drugs, nearly one in ten patients hospitalized with histoplasmosis dies. PMID: 17223625 Source: Regenstrief LOINC

Fully-Specified Name

Component
Histoplasma capsulatum DNA
Property
PrThr
Time
Pt
System
Respiratory system specimen.lower
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
H capsul DNA Lower resp Ql NAA+probe
Display Name
H. capsulatum DNA NAA+probe Ql (Lower resp)
Consumer Name Alpha Get Info
Histoplasma capsulatum, Lower respiratory

Example Answer List: LL3987-6

Source: New York State Health (Wadsworth Center)
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.77
Change Reason
Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC;
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
95919-7 Fungal pathogens panel - Lower respiratory specimen by NAA with probe detection

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Histoplasma capsulatum ADN:PrThr:Punto temporal:Muestra de vías respiratorias inferiores:Ord:Sonda con amplificación dirigida
Synonyms: Muestra del tracto respiratorio Muestra respiratoria Tracto respiratorio
es-MX Spanish (Mexico) ADN de Histoplasma capsulatum:Presencia o umbral:Punto temporal:Muestra de vías respiratorias inferiores:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Histoplasma capsulatum ADN:Présence/Seuil:Ponctuel:Voies respiratoires inférieures:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Histoplasma capsulatum DNA:PrThr:Pt:Campione da Sistema Respiratorio.inferiore:Ord:Sonda.amp.tar
Synonyms: Campione da Apparato Respiratorio Campione da apparato respiratorio inferiore Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL Dutch (Netherlands) Histoplasma capsulatum DNA:aanwezigheid:moment:onderste luchtwegen:ordinaal:probe-detectie
Synonyms: onderste ademhalingsstelsel; systema respiratorium inferior probe.amp.tar systema respiratorium; ademhalingsstelsel

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=95917-1