Version 2.76

Part Description

LP16650-1   Histoplasma capsulatum
Histoplasmosis capsulatum is a dimorphic fungal pathogen with filamentous or yeast forms,depending on nutritional factors and temperature.The M antigen is a well-known glycoprotein used as a diagnostic antigen for acute histoplasmosis as it induces the first precipitins during disease. Monoclonal antibodies (mAbs) to the M antigen have been found to modify the pathogenesis of histoplasmosis.Given the shortcomings of current therapies, the administration of mAbs is being investigated. PMID: 22347215 The H band is less commonly seen than the M band and is indicative of chronic or severe acute infections with H capsulatum.

H. capsulatum is found in nature primarily as a saprophytic mold. The mold form is comprised of hyaline septate hyphae, which produce two different asexual reproduction structures, macroconidia and microconidia. The micronidia are believed to be responsible for disease propagation since their 2-6 µm size is well suited for disposition into the distal alveoli. Infection is typically acquired through inhalation of fungal propagules upon disturbances of contaminated soil or excreta. Environmental and genetic factors influence disease manifestations which can range from asymptomatic or mild influenza-like disease to a disseminated sepsis form. Manifestations depend on the magnitude of exposure, the host's immunological status and the virulence of the infective strain. Reactivation of latent infection can result in significant disease, particularly for immunosuppressed individuals. Despite the availability of potent antifungal drugs, nearly one in ten patients hospitalized with histoplasmosis dies. PMID: 17223625 Source: Regenstrief LOINC

Fully-Specified Name

Component
Histoplasma capsulatum DNA
Property
PrThr
Time
Pt
System
Respiratory.lower
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
H capsul DNA Lower resp Ql NAA+probe
Display Name
H. capsulatum DNA NAA+probe Ql (Lower resp)
Consumer Name Alpha Get Info
Histoplasma capsulatum, Lower respiratory

Example Answer List: LL3987-6

Source: New York State Health (Wadsworth Center)
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.69
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
95919-7 Fungal pathogens panel - Lower respiratory specimen by NAA with probe detection

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Histoplasma capsulatum ADN:PrThr:Punto temporal:Muestra respiratoria de vías bajas:Ord:Sonda con amplificación dirigida
Synonyms: Muestra del tracto respiratorio inferior Muestra respiratoria Muestra respiratoria inferior
es-MX Spanish (Mexico) ADN de Histoplasma capsulatum:Presencia o umbral:Punto temporal:Muestra de vías respiratorias inferiores:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Histoplasma capsulatum ADN:Présence/Seuil:Ponctuel:Voies respiratoires inférieures:Qualitatif:PCR amplification de cible
fr-CA French (Canada) Histoplasma capsulatum , ADN:Présence-Seuil:Temps ponctuel:Système respiratoire.inférieur:Ordinal:Sonde avec amplification de la cible
it-IT Italian (Italy) Histoplasma capsulatum DNA:PrThr:Pt:Sistema respiratorio.inferiore:Ord:Sonda.amp.tar
Synonyms: Campione apparato respiratorio inferiore Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL Dutch (Netherlands) Histoplasma capsulatum DNA:aanwezigheid:moment:onderste luchtwegen:ordinaal:probe-detectie
Synonyms: onderste ademhalingsstelsel; systema respiratorium inferior probe.amp.tar systema respiratorium; ademhalingsstelsel
tr-TR Turkish (Turkey) Histoplazma Kapsulatum DNA:MevcEşik:Zmlı:Respiratuvar.alt:Srl:Prob.amf.hdf
Synonyms: Mevcut
zh-CN Chinese (China) 荚膜组织胞浆菌 DNA:存在情况或阈值:时间点:呼吸道.下:序数型:探针法.基因扩增.靶向
Synonyms: 下 下呼吸道;呼吸道(呼吸、呼吸系统).下;下呼吸道(呼吸、呼吸系统) 下的 下部 低级 低级的 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 去氧核糖核酸;脱氧核糖核酸 去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸(Deoxyribonucleic acid,DNA) 呼吸道标本(样品、样本);呼吸系统标本(样品、样本) 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 微生物学;微生物学试验;微生物学试验(培养、DNA、抗原及抗体) 扩增型 扩增性 时刻;随机;随意;瞬间 皮疽组织胞浆菌 DNA 皮疽组织胞浆菌;美洲型组织胞浆菌;鼻疽性组织浆菌 组织胞浆菌属 组织胞浆菌病 经过扩增的 美洲型组织胞浆菌 DNA 脱氧核糖核酸探针 较低 较低的 鼻疽性组织浆菌 DNA

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=95917-1