95917-1

Histoplasma capsulatum DNA [Presence] in Lower respiratory specimen by NAA with probe detection

Active

Part Description

LP16650-1 Histoplasma capsulatum
Histoplasmosis capsulatum is a dimorphic fungal pathogen with filamentous or yeast forms,depending on nutritional factors and temperature.The M antigen is a well-known glycoprotein used as a diagnostic antigen for acute histoplasmosis as it induces the first precipitins during disease. Monoclonal antibodies (mAbs) to the M antigen have been found to modify the pathogenesis of histoplasmosis.Given the shortcomings of current therapies, the administration of mAbs is being investigated. PMID: 22347215 The H band is less commonly seen than the M band and is indicative of chronic or severe acute infections with H capsulatum.

H. capsulatum is found in nature primarily as a saprophytic mold. The mold form is comprised of hyaline septate hyphae, which produce two different asexual reproduction structures, macroconidia and microconidia. The micronidia are believed to be responsible for disease propagation since their 2-6 µm size is well suited for disposition into the distal alveoli. Infection is typically acquired through inhalation of fungal propagules upon disturbances of contaminated soil or excreta. Environmental and genetic factors influence disease manifestations which can range from asymptomatic or mild influenza-like disease to a disseminated sepsis form. Manifestations depend on the magnitude of exposure, the host's immunological status and the virulence of the infective strain. Reactivation of latent infection can result in significant disease, particularly for immunosuppressed individuals. Despite the availability of potent antifungal drugs, nearly one in ten patients hospitalized with histoplasmosis dies. PMID: 17223625 Source: Regenstrief LOINC

Fully-Specified Name

Component: Histoplasma capsulatum DNA
Property: PrThr
Time: Pt
System: Respiratory system specimen.lower
Scale: Ord
Method: Probe.amp.tar

Additional Names

Long Common Name: Histoplasma capsulatum DNA [Presence] in Lower respiratory specimen by NAA with probe detection
Short Name: H capsul DNA Lower resp Ql NAA+probe
Display Name: H. capsulatum DNA NAA+probe Ql (Lower resp)
Consumer Name Alpha Get Info: Histoplasma capsulatum, Lower respiratory

Example Answer List: LL3987-6

Source: New York State Health (Wadsworth Center)

Answer	Code	Score	Answer ID
Detected			LA11882-0
Not detected			LA11883-8
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value)			LA11884-6

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.69
Last Updated: Version 2.77 (MAJ)
Change Reason: Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC;
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
95919-7	Fungal pathogens panel - Lower respiratory specimen by NAA with probe detection

Language Variants Get Info

Tag	Language	Translation
el-GR	Greek (Greece)	Histoplasma capsulatum (Ιστόπλασμα) DNA:PrThr:Pt:Δείγμα αναπνευστικού συστήματος.κατώτερο:Ord:Ανιχνευτής.ενίσχυση.στόχου Synonyms: DNA Histoplasma capsulatum (Ιστόπλασμα) PrThr
es-ES	Spanish (Spain)	Histoplasma capsulatum ADN:PrThr:Punto temporal:Muestra de vías respiratorias inferiores:Ord:Sonda con amplificación dirigida Synonyms: Muestra del tracto respiratorio Muestra respiratoria Tracto respiratorio
es-MX	Spanish (Mexico)	ADN de Histoplasma capsulatum:Presencia o umbral:Punto temporal:Muestra de vías respiratorias inferiores:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR	French (France)	Histoplasma capsulatum ADN:Présence/Seuil:Ponctuel:Échantillon du système respiratoire inférieur:Qualitatif:PCR amplification de cible
it-IT	Italian (Italy)	Histoplasma capsulatum DNA:PrThr:Pt:Campione da Sistema Respiratorio.inferiore:Ord:Sonda.amp.tar Synonyms: Campione da Apparato Respiratorio Campione da apparato respiratorio inferiore Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL	Dutch (Netherlands)	Histoplasma capsulatum DNA:aanwezigheid:moment:onderste luchtwegen:ordinaal:probe-detectie Synonyms: onderste ademhalingsstelsel; systema respiratorium inferior probe.amp.tar systema respiratorium; ademhalingsstelsel
zh-CN	Chinese (China)	荚膜组织胞浆菌 DNA:存在情况或阈值:时间点:呼吸系统标本.下:序数型:探针法.基因扩增.靶向 Synonyms: 下下的下部低级低级的供检查用的材料;待检物;待试验物;样品;样本;试料;试样依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向去氧核糖核酸;脱氧核糖核酸去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA）受检物呼吸系统（呼吸道）标本.下;下呼吸系统标本;下呼吸道标本呼吸道标本（样品、样本）;呼吸系统标本（样品、样本）存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间样品样本皮疽组织胞浆菌 DNA 皮疽组织胞浆菌;美洲型组织胞浆菌;鼻疽性组织浆菌组织胞浆菌属组织胞浆菌病经过扩增的美洲型组织胞浆菌 DNA 脱氧核糖核酸探针试样较低较低的鼻疽性组织浆菌 DNA

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=95917-1

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

LOINC Copyright

Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.