96121-9

SARS-related coronavirus E gene [Presence] in Lower respiratory specimen by NAA with probe detection

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Part Description

LP417600-6 SARS-related coronavirus E gene
The Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), first known as 2019 Novel Coronavirus (2019-nCoV), was first identified as the cause of a respiratory illness outbreak, later defined as Coronavirus Disease 2019 (COVID-19), in Wuhan, China. The full genome of the SARS-CoV-2 that causes COVID-19 was first posted by Chinese health authorities in GenBank, the NIH genetic sequence database, and in the Global Initiative on Sharing All Influenza Data (GISAI) portal. This facilitated detection of the virus globally with subsequent sequences being nearly identical, suggesting a single, recent emergence from a virus related to bat coronaviruses and the SARS coronavirus. Real time Reverse Transcription-Polymerase Chain Reaction (rRT-PCR) tests targeting regions within genes, including RdRp, S, N, M, and E genes, specific to SARS-CoV-2 have been developed by the Centers for Disease Control and Prevention (CDC), the World Health Organization (WHO) and others for the diagnosis of COVID-19. Some assays only detect SARS-CoV-2 and other assays detect other strains (e.g. SARS-CoV) that are genetically similar.[CDC: coronavirus/2019-ncov][https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/laboratory-guidance] Source: Regenstrief LOINC

Reference Information

Type	Source	Reference
Webcontent	Lab Tests Online^®Copyright Copyright © 2021 Lab Tests Online. All rights reserved.	Coronavirus (COVID-19) Testing
Mapping Guidance	LOINC	Take caution when mapping LOINC codes to molecular tests for SARS coronaviruses that target nucleic acids within the E gene. Such assays detect either SARS-related coronavirus or SARS-CoV-2, depending on the targeted region within the E gene. Assays that are non-specific to only SARS-CoV-2 may say they are "positive" for SARS-CoV-2, but only because it is the primary circulating virus during the pandemic. These assays actually detect any SARS-related coronaviruses since they target a region in the E gene that contains sequence homology to other known coronaviruses. Other assays target a region in the E gene that is specific for SARS-CoV-2. The LIVD file contains current LOINC code mappings to many IVD tests [https://www.cdc.gov/csels/dls/sars-cov-2-livd-codes.html]. You may also contact the manufacturer directly to verify LOINC code mappings.

Fully-Specified Name

Component: SARS-related coronavirus E gene
Property: PrThr
Time: Pt
System: Respiratory system specimen.lower
Scale: Ord
Method: Probe.amp.tar

Additional Names

Long Common Name: SARS-related coronavirus E gene [Presence] in Lower respiratory specimen by NAA with probe detection
Short Name: SARS-rel CoV E gene Low resp Ql NAA+prb
Display Name: SARS-related coronavirus E gene NAA+probe Ql (Lower resp)
Consumer Name Alpha Get Info: SARS-related coronavirus E gene, Lower respiratory

Example Answer List: LL2021-5

Source: Gen-Probe

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6
InvalidCopyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value)			LA15841-2

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.69
Last Updated: Version 2.77 (MAJ)
Change Reason: Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC;
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
94393-6	Respiratory pathogens DNA and RNA panel - Lower respiratory specimen by NAA with probe detection

Member of these Groups Get Info

LOINC Group	Group Name
LG50982-4	SARS-related coronavirus
LG51048-3	SARS-related coronavirus E gene\|PrThr\|Sys:ANYResp

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: SARS-CoV-2 E-Gen ql. /BAL PCR
de-DE	German (Germany)	SARS-bezogenes Coronavirus E-Gen:Nachweis oder Schwellenwert:Zeitpunkt:Respirationstrakt.unterer:Ordinal:Zielfragmentamplifikation mit Sondendetektion
el-GR	Greek (Greece)	Γονίδιο Ε κορονοϊού που σχετίζεται με το SARS:PrThr:Pt:Δείγμα αναπνευστικού συστήματος.κατώτερο:Ord:Ανιχνευτής.ενίσχυση.στόχου Synonyms: E PrThr Γονίδιο Γονίδιο Ε κορονοϊού που σχετίζεται με το SARS Κορωνοϊός Κορωνοϊός που σχετίζεται με το SARS
es-ES	Spanish (Spain)	Gen del coronavirus E relacionado con el SARS:PrThr:Punto temporal:Muestra de vías respiratorias inferiores:Ord:Sonda con amplificación dirigida Synonyms: Muestra del tracto respiratorio Muestra respiratoria Tracto respiratorio
es-MX	Spanish (Mexico)	Gen del coronavirus E relacionado con el SARS:Presencia o umbral:Punto temporal:Muestra de vías respiratorias inferiores:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR	French (France)	Coronavirus SARS apparentés gène E:Présence/Seuil:Ponctuel:Échantillon du système respiratoire inférieur:Qualitatif:PCR amplification de cible
it-IT	Italian (Italy)	Coronavirus correlato a SARS, gene E:PrThr:Pt:Campione da Sistema Respiratorio.inferiore:Ord:Sonda.amp.tar Synonyms: Campione da Apparato Respiratorio Campione da apparato respiratorio inferiore Gene E di coronavirus correlato a SARS Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL	Dutch (Netherlands)	SARS-gerelateerd coronavirus E-gen:aanwezigheid:moment:onderste luchtwegen:ordinaal:probe-detectie Synonyms: onderste ademhalingsstelsel; systema respiratorium inferior probe.amp.tar systema respiratorium; ademhalingsstelsel
zh-CN	Chinese (China)	SARS 冠状病毒 2 E 基因:存在情况或阈值:时间点:呼吸系统标本.下:序数型:探针法.基因扩增.靶向 Synonyms: 2019 新型冠状病毒;2019 年新型冠状病毒;2019-nCoV;SARS-CoV-2;新型冠状病毒肺炎;新冠肺炎;Coronavirus disease 2019;COVID-19;冠状病毒疾病2019;严重急性呼吸综合征;severe acute respiratory syndrome;SARS;传染性非典型肺炎;infectious atypical pneumonia;非典 E 型下下的下部严重急性呼吸综合征;severe acute respiratory syndrome;SARS;传染性非典型肺炎;infectious atypical pneumonia;非典低级低级的供检查用的材料;待检物;待试验物;样品;样本;试料;试样依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向受检物呼吸系统（呼吸道）标本.下;下呼吸系统标本;下呼吸道标本呼吸道标本（样品、样本）;呼吸系统标本（样品、样本）存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间样品样本经过扩增的脱氧核糖核酸探针试样较低较低的遗传基因;遗传因子;吉恩;生物基因

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