Version 2.76

Part Description

LP417600-6   SARS-related coronavirus E gene
The Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), first known as 2019 Novel Coronavirus (2019-nCoV), was first identified as the cause of a respiratory illness outbreak, later defined as Coronavirus Disease 2019 (COVID-19), in Wuhan, China. The full genome of the SARS-CoV-2 that causes COVID-19 was first posted by Chinese health authorities in GenBank, the NIH genetic sequence database, and in the Global Initiative on Sharing All Influenza Data (GISAI) portal. This facilitated detection of the virus globally with subsequent sequences being nearly identical, suggesting a single, recent emergence from a virus related to bat coronaviruses and the SARS coronavirus. Real time Reverse Transcription-Polymerase Chain Reaction (rRT-PCR) tests targeting regions within genes, including RdRp, S, N, M, and E genes, specific to SARS-CoV-2 have been developed by the Centers for Disease Control and Prevention (CDC), the World Health Organization (WHO) and others for the diagnosis of COVID-19. Some assays only detect SARS-CoV-2 and other assays detect other strains (e.g. SARS-CoV) that are genetically similar.[CDC: coronavirus/2019-ncov][https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/laboratory-guidance] Source: Regenstrief LOINC

Reference Information

Type Source Reference
Webcontent Lab Tests Online®Copyright Copyright © 2021 Lab Tests Online. All rights reserved. Coronavirus (COVID-19) Testing
Mapping Guidance LOINC Take caution when mapping LOINC codes to molecular tests for SARS coronaviruses that target nucleic acids within the E gene. Such assays detect either SARS-related coronavirus or SARS-CoV-2, depending on the targeted region within the E gene. Assays that are non-specific to only SARS-CoV-2 may say they are "positive" for SARS-CoV-2, but only because it is the primary circulating virus during the pandemic. These assays actually detect any SARS-related coronaviruses since they target a region in the E gene that contains sequence homology to other known coronaviruses. Other assays target a region in the E gene that is specific for SARS-CoV-2. The LIVD file contains current LOINC code mappings to many IVD tests [https://www.cdc.gov/csels/dls/sars-cov-2-livd-codes.html]. You may also contact the manufacturer directly to verify LOINC code mappings.

Fully-Specified Name

Component
SARS-related coronavirus E gene
Property
PrThr
Time
Pt
System
Respiratory.lower
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
SARS-rel CoV E gene Low resp Ql NAA+prb
Display Name
SARS-related coronavirus E gene NAA+probe Ql (Lower resp)
Consumer Name Alpha Get Info
SARS-related coronavirus E gene, Lower respiratory

Example Answer List: LL2021-5

Source: Gen-Probe
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
InvalidCopyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value) LA15841-2

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.69
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
94393-6 Respiratory pathogens DNA and RNA panel - Lower respiratory specimen by NAA with probe detection

Member of these Groups Get Info

LOINC Group Group Name
LG50982-4 SARS-related coronavirus
LG51048-3 SARS-related coronavirus E gene|PrThr|Sys:ANYResp

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: SARS-CoV-2 E-Gen ql. /BAL PCR
de-DE German (Germany) SARS-bezogenes Coronavirus E-Gen:Nachweis oder Schwellenwert:Zeitpunkt:Respirationstrakt.unterer:Ordinal:Zielfragmentamplifikation mit Sondendetektion
es-ES Spanish (Spain) Gen del coronavirus E relacionado con el SARS:PrThr:Punto temporal:Muestra respiratoria de vías bajas:Ord:Sonda con amplificación dirigida
Synonyms: Muestra del tracto respiratorio inferior Muestra respiratoria Muestra respiratoria inferior
es-MX Spanish (Mexico) Gen del coronavirus E relacionado con el SARS:Presencia o umbral:Punto temporal:Muestra de vías respiratorias inferiores:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Coronavirus SARS apparentés gène E:Présence/Seuil:Ponctuel:Voies respiratoires inférieures:Qualitatif:PCR amplification de cible
fr-CA French (Canada) gène E du coronavirus 2 du SRAS:Présence-Seuil:Temps ponctuel:Système respiratoire.inférieur:Ordinal:Sonde avec amplification de la cible
it-IT Italian (Italy) Coronavirus correlato a SARS, gene E:PrThr:Pt:Sistema respiratorio.inferiore:Ord:Sonda.amp.tar
Synonyms: Campione apparato respiratorio inferiore Gene E di coronavirus correlato a SARS Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL Dutch (Netherlands) SARS-gerelateerd coronavirus E-gen:aanwezigheid:moment:onderste luchtwegen:ordinaal:probe-detectie
Synonyms: onderste ademhalingsstelsel; systema respiratorium inferior probe.amp.tar systema respiratorium; ademhalingsstelsel
zh-CN Chinese (China) SARS 冠状病毒 2 E 基因:存在情况或阈值:时间点:呼吸道.下:序数型:探针法.基因扩增.靶向
Synonyms: 2019 新型冠状病毒;2019 年新型冠状病毒;2019-nCoV;SARS-CoV-2;新型冠状病毒肺炎;新冠肺炎;Coronavirus disease 2019;COVID-19;冠状病毒疾病2019;严重急性呼吸综合征;severe acute respiratory syndrome;SARS;传染性非典型肺炎;infectious atypical pneumonia;非典 E 型 下 下呼吸道;呼吸道(呼吸、呼吸系统).下;下呼吸道(呼吸、呼吸系统) 下的 下部 严重急性呼吸综合征;severe acute respiratory syndrome;SARS;传染性非典型肺炎;infectious atypical pneumonia;非典 低级 低级的 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 呼吸道标本(样品、样本);呼吸系统标本(样品、样本) 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 微生物学;微生物学试验;微生物学试验(培养、DNA、抗原及抗体) 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 较低 较低的 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=96121-9