Version 2.79

Term Description

This term represents the percentage of T cells (Cells.CD3+CD14-CD45+) that express the DOCK8 protein.

Part Descriptions

LP420095-4   Cells.CD3+CD14-CD45+DOCK8+
Dedicator of cytokinesis 8 (DOCK8) protein plays a role in regulating the cellular cytoskeleton, particularly microfilaments. DOCK8 is important in immunity by contributing to cellular migration, cytotoxicity, antibody production, and immunological memory. Deficiency of DOCK8 causes an immunodeficiency that presents in childhood with features including recurrent sinopulmonary infections, cutaneous viral infection, Staphylococcus aureus skin infections, cancer, and atopic disease (due to hyperimmunoglobulin E). NK cells (CD45+CD14-CD3-CD56+), T cells (CD3+CD14-CD45+), B cells (CD3-CD14-CD19+CD45+), and monocytes (CD45+CD14+) are all expected to express the DOCK8 protein. Therefore, assessment of DOCK8 expression on immune cells facilitates the diagnosis of DOCK8 deficiency. PMID: 28625885 Source: Regenstrief LOINC

LP17733-4   CD14
Found on Monocytes
Associated with some AML Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD3+CD14-CD45+DOCK8+/Cells.CD3+CD14-CD45+
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method
Flow cytometry

Additional Names

Long Common Name
Cells.CD3+CD14-CD45+DOCK8+/Cells.CD3+CD14-CD45+ in Blood by Flow cytometry (FC)
Short Name
T Cells DOCK8+/T Cells NFr Bld FC
Display Name
Cells.CD3+CD14-CD45+DOCK8+/Cells.CD3+CD14-CD45+ FC (Bld)
Consumer Name Alpha Get Info
Cells.CD3+CD14-CD45+DOCK8+/Cells.CD3+CD14-CD45+, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.79 (NAM)
Change Reason
Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
96415-5 DOCK8 expression panel - Blood by Flow cytometry (FC)

Language Variants Get Info

Tag Language Translation
es-MX Spanish (Mexico) Cells.CD3 + CD14-CD45 + DOCK8 + / 100 Cells.CD3 + CD14-CD45 +:Fracción numérica:Punto temporal:Sangre:Cuantitativo:Citometría de flujo (FC)
es-ES Spanish (Spain) Células CD3+CD14-CD45+DOCK8+/100 células CD3+CD14-CD45+:Fracción numérica:Punto temporal:Sangre:Qn:Citometria de flujo (FC)
Synonyms: Cuantitativo
fr-FR French (France) CD3+CD14-CD45+DOCK8+/100 cellules CD3+CD14-CD45+:Fraction de nombres:Ponctuel:Sang:Numérique:Cytométrie de flux
it-IT Italian (Italy) Cellule.CD3+CD14-CD45+DOCK8+/Cellule.CD3+CD14-CD45+:NFr:Pt:Sangue:Qn:Citometria a flusso
Synonyms: Cellule CD3 Cellule.CD3+CD14-CD45+ Citometria a flusso (FC) Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
nl-NL Dutch (Netherlands) cellen.CD3+CD14-CD45+DOCK8+/100 cellen.CD3+CD14-CD45+:getalsfractie:moment:bloed:kwantitatief:flowcytometrie
zh-CN Chinese (China) 细胞.CD3+CD14-CD45+DOCK8+/细胞.CD3+CD14-CD45+:计数型分数:时间点:全血:定量型:流式细胞测量术
Synonyms: B220;CD45R;CD45RA;CD45RB;CD45RC;CD45RO;LCA;Ly5;T200;白细胞共同 Ag;白细胞共同分化 Ag;白细胞共同分化抗原;白细胞共同抗原 CD3细胞 Leu4;Leu-4;T3 LeuM3 Leu-M3 LPS-R Mo2 Mo-2 My4 My-4 动态 发现于单核细胞之上，与某些急性髓系白血病（AML）相关。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 脂多糖受体（LPS receptor，LPS-R） 血;血液

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=96416-3