99076-2

Alpha-1-Microglobulin [Mass/volume] in 24 hour Urine

Active

Part Description

LP40499-3 Alpha-1-Microglobulin
Alpha-1-microglobulin (also called protein HC or A1M) is a 31-kD, single-chain plasma glycoprotein that may be involved in regulation of the inflammatory process. The alpha-1-microglobulin/bikunin precursor gene (AMBP) codes for a precursor that splits into alpha-1-microglobulin, which belongs to the lipocalin superfamily, and bikunin. A1M is normally present as a free form and as a complex with IgA in the blood, spinal fluid, and urine. A1M inhibits neutrophil chemotaxis to endotoxin-activated serum. [OMIM: 176870] Abnormal plasma/serum levels can be seen in liver or kidney disorders, and also in clinical conditions such as HIV and mood disorders. Urinary A1M is used for the early detection and monitoring of kidney tubular disorders such as heavy metal intoxications, diabetic nephropathy, urinary outflow disorders or pyelonephritis). PMID: 15256311 Increased urinary excretion of α1-microglobulin in tubular proteinuria indicates reduced tubular reabsorption under normal glomerular filtration conditions. This form of proteinuria is typical for chronic interstitial nephropathy and for acute and chronic tubular damage caused by endogenous and exogenous tubular toxins. In renal failure, plasma levels of this microprotein increase from an early stage. The resultant protein hyperfiltration in the residual nephron causes increased renal excretion as re-absorption capacity is exceeded. α1-Microglobulin can be used as a marker to diagnose tubulo-interstitial nephropathy, for example, at an early stage, or rule it out with a high degree of certainty. Acute and chronic forms of tubular insufficiency (all forms of primary and secondary Fanconi syndrome), heavy metal intoxication, nephrotoxic side-effects of pharmaceuticals, and rejection reactions following kidney transplantation can also be excluded. Source: Regenstrief LOINC, PMID: 15256311

LOINC Names Get Info

Fully-Specified Name: Alpha-1-Microglobulin:MCnc:24H:Urine:Qn:
Long Common Name: Alpha-1-Microglobulin [Mass/volume] in 24 hour Urine
Short Name: A1 Microglob 24h Ur-mCnc
Display Name: Alpha-1-Microglobulin (24H U) [Mass/Vol]
Consumer Name Alpha Get Info: Alpha-1-Microglobulin, Urine

Part Model Get Info

Component
Alpha-1-Microglobulin
LP40499-3
- Analyte
  Alpha-1-Microglobulin
  LP40499-3
  - Component Numerator
    Alpha-1-Microglobulin
    LP40499-3
    - Component Numerator Core
      Alpha-1-Microglobulin
      LP40499-3
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
24H
LP6924-7
- Time Core
  24H
  LP6924-7
- Time Modifier
  NULL
System
Urine
LP7681-2
- System Core
  Urine
  LP7681-2
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.72
Last Updated: Version 2.72 (ADD)
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG51320-6	Alpha-1-Microglobulin\|MCnc\|Urine

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Alfa-1-mikroglobulin:Hmotnostní koncentrace:24 hodin:Moč:Kvantitativní:
el-GR	Greek (Greece)	Α-1-μικροσφαιρίνη:MCnc:24H:Ούρα:Qn: Synonyms: 24H CHEM MCnc Qn Α-1-μικροσφαιρίνη Ούρα
es-ES	Spanish (Spain)	Alfa 1-microglobulina:Concentración de masa:24 horas:Orina:Qn: Synonyms: Cuantitativo
et-EE	Estonian (Estonia)	Alfa-1-mikroglobuliin:MCnc:24 tunni:U:Qn: Synonyms: Kvantitatiivne Uriin
fr-CA	French (Canada)	Alpha-1-microglobuline:Concentration de masse:24 h:Urine:Quantitatif:
fr-BE	French (Belgium)	Alpha-1-microglobuline:Concentration de masse:24 h:Urine:Quantitatif:
fr-FR	French (France)	Alpha-1-microglobuline:Masse/Volume:24H:Urine:Numérique:
it-IT	Italian (Italy)	Alfa-1-Microglobulina:MCnc:24h:Urine:Qn: Synonyms: 24 Ore Chimica Concentrazione di Massa
nl-NL	Dutch (Netherlands)	alfa-1-microglobuline:massa/volume:24 uur:urine:kwantitatief: Synonyms: 24U
pl-PL	Polish (Poland)	Alfa-1-mikroglobulina:stężenie masowe:24h:mocz:ilościowy: Synonyms: 24 godziny
ru-RU	Russian (Russian Federation)	Альфа-1-Микроглобулин:МассКонц:24 часа:Моча:Колич: Synonyms: Количественный Массовая концентрация
tr-TR	Turkish (Turkey)	Alfa-1-Mikroglobulin:KütlKons:24Sa:İdrar:Kant:
zh-CN	Chinese (China)	Alpha-1-微球蛋白:质量浓度:24小时:尿液:定量型: Synonyms: 1天;1日;24.0小时;一天;一日;二十四个小时;二十四小时 Ⅰ A1 型 A1MG;A-1-MG;A1-MG;Alpha-1-MG;Alpha-1-小球蛋白;Alpha1-小球蛋白;Alpha-1-微小球蛋白;Alpha1-微小球蛋白;Alpha-1-微小糖蛋白;Alpha1-微小糖蛋白;Alpha1-微球蛋白;HC;α1-MG;α1-小球蛋白;α1-微小球蛋白;α1-微小糖蛋白;α1-微球蛋白;人复合蛋白;人复合蛋白（Protein Human Complex，human complexforming protein，HC） I α α1 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺尿;小便;下泉水平;浓度;质量浓度(单位体积) 阿尔法

Example Units

Unit	Source
mg/dL	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.