99116-6

Bourbon virus neutralizing antibody [Titer] in Specimen by Neutralization test

Active

Part Descriptions

LP207365-0 Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP421094-6 Bourbon virus
Bourbon virus was identified in Bourbon County, Kansas in 2014. Bourbon virus belongs to the group of viruses called thogotoviruses. Bourbon virus is an enveloped RNA virus belonging to the family Orthomyxoviridae, genus Thogotovirus [NCBI Taxonomy: 1618189] PMID: 31419524. Mode of transmission is unknown, but likely occurs through tick or other insect bites. Symptoms include fever, fatigue, maculopapular rash, headache, body aches, nausea, and vomiting. Thrombocytopenia and leukopenia have also been reported [CDC: ncezid/dvbd/bourbon/index.html]. Source: Regenstrief LOINC,

LP6416-4 Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Bourbon virus Ab.Neut:Titr:Pt:XXX:SemiQn:Neut
Long Common Name: Bourbon virus neutralizing antibody [Titer] in Specimen by Neutralization test
Short Name: Bourbon virus NAb Titr Spec Nt
Display Name: Bourbon virus neut ab Neut test (Specimen) [Titer]
Consumer Name Alpha Get Info: Bourbon virus neutralizing antibody, Specimen

Part Model Get Info

Component
Bourbon virus Ab.Neut
LP430320-4
- Analyte
  Bourbon virus Ab.Neut
  LP430320-4
  - Component Numerator
    Bourbon virus Ab.Neut
    LP430320-4
    - Component Numerator Core
      Bourbon virus
      LP421094-6
    - Component Numerator Core Suffix
      Ab.Neut
      LP207365-0
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Titr
LP6881-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
XXX
LP7735-6
- System Core
  XXX
  LP7735-6
- Super System
  NULL
Scale
SemiQn
LP436123-6
Method
Neut
LP6416-4

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.72
Last Updated: Version 2.75 (MAJ)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Virus Bourbon Ab.neutralizační:Arbitrární koncentrace (titr):Časový bod:XXX:Semikvantitativní:Neutralizační test
el-GR	Greek (Greece)	Ιός Bourbon Ab.Neut:Titr:Pt:XXX:Ημιποσοτική:Ουδετερόφιλα Synonyms: Ab.Neut MICRO Pt Titr XXX Αντίσωμα Ημιποσοτική Ιός Ιός Bourbon Ουδετερόφιλα
es-ES	Spanish (Spain)	Virus Bourbon Anticuerpos antineutrófilos:Titulo / Factor de dilución:Punto temporal:XXX:Semicuantitativo:Prueba de neutralización Synonyms: Semicuantitativo
fr-FR	French (France)	Virus Bourbon Ac neutralisant:Titre:Ponctuel:Milieux divers:Semi-Quantitatif:Neutralisation
it-IT	Italian (Italy)	Bourbon virus Ab.Neut:Titr:Pt:XXX:SemiQn:Neut Synonyms: anticorpo BOUV Microbiologia Punto nel tempo (episodio) Test di neutralizzazione Titolo
nl-NL	Dutch (Netherlands)	Bourbon-virus As.neutraliserend:titer:moment:XXX:semikwantitatief:neutralisatietest Synonyms: antistof; antilichaam
pl-PL	Polish (Poland)	Wirus Bourbon Ab.Neutralizujące:miano:punkt w czasie:XXX:półilościowy:test neutralizacji Synonyms: Przeciwciała neutralizujące do wirusa Bourbon Wirus Bourbon
zh-CN	Chinese (China)	波旁病毒抗体.中和:滴定度:时间点:XXX:半定量型:中和试验 Synonyms: Ab;自身抗体 BRBV 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项中和试验;中和抗体;中和传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数时刻;随机;随意;瞬间

Example Units

Unit	Source
{titer}	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=99116-6

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.